Výsledky vyhledávání - "Charles M. Beasley"

Reference Limits for Outlier Analyses in Randomized Clinical Trials

Autor: Brenda J. Crowe, Paul S. Horn, Charles M. Beasley, Rebeka Tabbey, Robert A. Dean, Lieling Wu, Mary E. Nilsson, Ryan T. Hietpas

Publikováno v: Therapeutic Innovation & Regulatory Science. 51:683-737

Reference limits used in clinical medicine to screen and manage patients are typically developed nonparametrically using reference values from a limited number of healthy subjects using a 95th percentile reference interval. We have evaluated alternat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a2a51ab9ef779b0b5b5ca3c480d30d
https://doi.org/10.1177/2168479017700679

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Twenty-Four-Hour Measures of Heart Rate-Corrected QT Interval, Peak-to-End of the T-Wave, and Peak-to-End of the T-Wave/Corrected QT Interval Ratio During Antipsychotic Treatment

Autor: Mustafa M. Tümüklü, Mevhibe N. Tümüklü, Herbert Y. Meltzer, Charles M. Beasley, Vladislav Nesterenko, Karu Jayathilake

Publikováno v: Journal of clinical psychopharmacology. 39(2)

PURPOSE/BACKGROUND Prolonged ventricular repolarization, measured by heart rate-corrected QT interval (QTc) prolongation, might be a biomarker for risk of torsade de pointes (TdP) and sudden cardiac death. However, the predictive value of QTc has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776947fd71c729e4f92f29a5d5c5eefe
https://pubmed.ncbi.nlm.nih.gov/30707117

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Adaptation of the robust method to large distributions of reference values: program modifications and comparison of alternative computational methods

Autor: Lieling Wu, Brenda J. Crowe, Rebeka Tabbey, Robert A. Dean, Paul S. Horn, Ryan T. Hietpas, Mary E. Nilsson, Charles M. Beasley

The objective of this research was to compute reference limits using reference values from patients entering pharmaceutical development clinical trials by the nonparametric method and the robust method of Horn and Pesce, with and without outlier excl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bb60637f5b4d17247fa29240ade399

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Effects of atomoxetine on the QT interval in healthy CYP2D6 poor metabolizers

Autor: Malcolm I. Mitchell, John H. April, Prajakti A. Kothare, Charles M. Beasley, Ling Jin, Harry Haber, Lynnette Kauffman, Corina Loghin, Albert J. Allen

Publikováno v: British Journal of Clinical Pharmacology. 75:549-564

Aim The effects of atomoxetine (20 and 60 mg twice daily), 400 mg moxifloxacin and placebo on QTc in 131 healthy CYP2D6 poor metabolizer males were compared.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1157c763b00d749b6d0fe3d3ead2daec
https://doi.org/10.1111/j.1365-2125.2012.04382.x

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Systematic Decrements in QTc between the First and Second Day of Contiguous Daily ECG Recordings under Controlled Conditions

Autor: S. Stanley Young, Charles M. Beasley, Jessie Q. Xia, Charles Benson, Harry Haber, Corina Loghin, Malcolm I. Mitchell

Publikováno v: Pacing and Clinical Electrophysiology. 34:1116-1127

Background: Many thorough QT (TQT) studies use a baseline day and double delta analysis to account for potential diurnal variation in QTc. However, little is known about systematic changes in the QTc across contiguous days when normal volunteers are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68ed0cf70c19967da12b4b2f5874b94e
https://doi.org/10.1111/j.1540-8159.2011.03117.x

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Evaluating suicide-related adverse events in clinical trials of fluoxetine treatment in adults for indications other than major depressive disorder

Autor: Damon Disch, Charles M. Beasley, John Plewes, Sitra Tauscher-Wisniewski, Susan Ball

Publikováno v: Psychological Medicine. 37:1585-1593

BackgroundThe association between treatment-emergent suicidality as an adverse event and fluoxetine treatment was examined using a fluoxetine double-blind placebo-controlled database of clinical trials for indications other than major depressive diso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7227b9d659bc4582bbae431d6c70f7c4
https://doi.org/10.1017/s0033291707001146

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Early Symptomatic Worsening During Treatment With Fluoxetine in Major Depressive Disorder

Autor: Jay D. Amsterdam, Roy H. Perlis, Maurizio Fava, Frederic M. Quitkin, Jerrold F. Rosenbaum, Cristina Cusin, Frederick W. Reimherr, Charles M. Beasley

Publikováno v: The Journal of Clinical Psychiatry. 68:52-57

Background A subset of patients experience worsening of depressed mood after beginning antidepressant treatment, which could represent the natural history of the illness or a treatment-related effect. While patterns of response have been examined as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcad7da9a4ef744736e9d2fa56c9ab6
https://doi.org/10.4088/jcp.v68n0107

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Treatment-Associated Suicidal Ideation and Adverse Effects in an Open, Multicenter Trial of Fluoxetine for Major Depressive Episodes

Autor: Roy H. Perlis, Frederick M. Quitkin, Deborah L. Shear, Jerrold F. Rosenbaum, Charles M. Beasley, Roy N. Tamura, James D. Wines, Cristina Cusin, Maurizio Fava, Robert E. Strong, Jay D. Amsterdam

Publikováno v: Psychotherapy and Psychosomatics. 76:40-46

Background: Some reports suggest that a subset of depressed patients may experience suicidality – that is increase or emergence of suicidal ideation (SI) or behavior – after initiation of an antidepressant. The time course and clinical correlates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e580a47980f2dc67091d08b6e666cc
https://doi.org/10.1159/000096363

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