Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Charles M. Allan"'
Publikováno v:
Transgenic Animals ISBN: 9781003211099
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5d76c3c186794bed313004274afb590
https://doi.org/10.1201/9781003211099-55
https://doi.org/10.1201/9781003211099-55
Autor:
Reena Desai, Kirsty A Walters, David J. Handelsman, Charles M. Allan, Dannielle H. Upton, Emily K. Colvin, Emily S. Fuller, Mark Jimenez, Viive M. Howell
Publikováno v:
Hormones and Cancer. 6:142-152
BRCA1 mutations are associated with ovarian cancer. Previous studies reported that murine granulosa cell (GC) Brca1 loss caused ovarian-uterine tumors resembling serous cystadenomas, but the pathogenesis of these tumors may have been confounded by ec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf8292cee6d313f0ecee4a57ba7c34fe
https://doi.org/10.1007/s12672-015-0222-5
https://doi.org/10.1007/s12672-015-0222-5
Autor:
Charles M. Allan, Dannielle H. Upton, Rasmani Hazra, Reena Desai, David J. Handelsman, Mark Jimenez
Publikováno v:
Endocrinology. 155:1120-1130
We determined the functional role of the Sertoli cell glucocorticoid receptor (GR) in vivo using a transgenic Cre-loxP approach to conditionally disrupt GR expression. Sertoli cell GR knockout (SCGRKO) was shown by absent Sertoli cell-specific GR imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867eae792e7b1685b50b0b14bd8ad70e
https://doi.org/10.1210/en.2013-1940
https://doi.org/10.1210/en.2013-1940
Autor:
Jeremy Troy Smith, Mark Jimenez, Kirsty A Walters, Reena Desai, Charles M. Allan, Shai R. Joseph, Guang Ning, Xiaobing B. Cheng, David J. Handelsman, Linda J. Middleton
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 305:E717-E726
Homozygous androgen receptor (AR)-knockout (ARKO) female mice are subfertile due to both intra- and extraovarian (neuroendocrine) defects as defined by ovary transplantation. Using ARKO mice, this study set out to reveal the precise AR-regulated path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7f38833057ceb823cc3a2adaf96098
https://doi.org/10.1152/ajpendo.00263.2013
https://doi.org/10.1152/ajpendo.00263.2013
Autor:
Charles M. Allan, Rasmani Hazra, David J. Handelsman, Lisa Corcoran, Mat Robson, Dannielle H. Upton, Kirsten J. McTavish
Publikováno v:
Molecular Endocrinology. 27:12-24
Sertoli cell (SC) androgen receptor (AR) activity is vital for spermatogenesis. We created a unique gain-of-function transgenic (Tg) mouse model to determine the temporal role of SCAR expression in testicular development. The SC-specific rat Abpa pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159ccd6cdeba84f6eea2c21eb445d4aa
https://doi.org/10.1210/me.2012-1219
https://doi.org/10.1210/me.2012-1219
Sertoli Cell Androgen Receptor DNA Binding Domain Is Essential for the Completion of Spermatogenesis
Autor:
Patrick Lim, Jenny Spaliviero, Charles M. Allan, Kirsten J. McTavish, David J. Handelsman, Mark Jimenez, Mathew Robson, Jeffrey D Zajac
Publikováno v:
Endocrinology. 150:4755-4765
We examined the biological importance of Sertoli cell androgen receptor (AR) genomic interaction, using a Cre-loxP approach to selectively disrupt the AR DNA-binding domain (AR-DBD). Sertoli cell (SC)-specific transgenic Abpa or AMH promoters targete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1826ddf16e69d7fd159a85ac39f82fa
https://doi.org/10.1210/en.2009-0416
https://doi.org/10.1210/en.2009-0416
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 296:E1022-E1028
We have characterized the in vivo actions of human wild-type FSH receptor (FSHR) overexpressed in Sertoli cells of transgenic (Tg) mice ( TgFSHRwt) compared with transgenic overexpression of the human activated mutant FSHR*D567G ( TgFSHR*D567G). Test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a660939209f5d83ae4ff3681ca0d602
https://doi.org/10.1152/ajpendo.90941.2008
https://doi.org/10.1152/ajpendo.90941.2008
Publikováno v:
Biology of Reproduction. 78:380-389
Although androgens and the androgen receptor (AR) have defining roles in male reproductive development and function, previously no role in female reproductive physiology beyond testosterone (T) as the precursor in estradiol (E(2)) biosynthesis was fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f951d6781d637c58c147ab86495a5ff8
https://doi.org/10.1095/biolreprod.107.064089
https://doi.org/10.1095/biolreprod.107.064089
Autor:
Axel P. N. Themmen, Kirsty A Walters, Jenny A. Visser, Mark Jimenez, Kirsten J. McTavish, Charles M. Allan, Nigel P. Groome, Jennifer A. Spaliviero, David J. Handelsman
Publikováno v:
Endocrinology, 148(9), 4432-4439. Endocrine Society
Rising serum FSH levels is one of the earliest signs of human female reproductive aging. Whether or not elevated FSH remains a passive reflection of a diminishing ovarian follicle pool or actively contributes to declining female fertility with age ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0261dacf89c0bca292bc5dfc44f996
https://hdl.handle.net/1765/35242
https://hdl.handle.net/1765/35242
Autor:
Reena Desai, Aimee S L Caldwell, Charles M. Allan, Aisling C. McMahon, David J. Handelsman, Mark Jimenez, S. Eid, Jeremy Troy Smith, Kirsty A Walters, C.R. Kay
Publikováno v:
Endocrinology. 156(4)
Polycystic ovary syndrome (PCOS) is associated with reproductive, endocrine, and metabolic abnormalities. Because hyperandrogenism is the most consistent PCOS feature, we used wild-type (WT) and androgen receptor (AR) knockout (ARKO) mice, together w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e93942f7fb6ddb6bdcc19bef4bf0e93
https://pubmed.ncbi.nlm.nih.gov/25643156
https://pubmed.ncbi.nlm.nih.gov/25643156