Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Charles M, Stevens"'
Autor:
Alison Y Li, Charles M Stevens, Bo Liang, Kaveh Rayani, Sean Little, Jonathan Davis, Glen F Tibbits
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79363 (2013)
The Ca(2+) binding properties of the FHC-associated cardiac troponin C (cTnC) mutation L29Q were examined in isolated cTnC, troponin complexes, reconstituted thin filament preparations, and skinned cardiomyocytes. While higher Ca(2+) binding affinity
Externí odkaz:
https://doaj.org/article/f6acca3de1ee4c558cb5e0bb294a4ef7
Autor:
Gurpreet Singh, Charles M. Stevens, D. Peter Tieleman, Bairam Lotfalisalmasi, Kaveh Rayani, Glen F. Tibbits
Publikováno v:
Journal of Biological Chemistry. 292:11915-11926
Cardiac troponin C (cTnC) is the regulatory protein that initiates cardiac contraction in response to Ca2+. TnC binding Ca2+ initiates a cascade of protein–protein interactions that begins with the opening of the N-terminal domain of cTnC, followed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e4451f675636e41a16dc32f9b00baf9
https://doi.org/10.1074/jbc.m116.770776
https://doi.org/10.1074/jbc.m116.770776
Autor:
D. Peter Tieleman, Charles M. Stevens, Ryan D. Morin, Sanam Shafaattalab, Eric Lin, Laura J. Dewar, Glen F. Tibbits, Jonathan P. Davis, Francis C. Lynn, Zachary Laksman, Filip Van Petegem, Leif Hove-Madsen, Alison Yueh Li, Shubhayan Sanatani
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Sudden unexpected death of an infant (SUDI) is a devastating occurrence for families. To investigate the genetic pathogenesis of SUDI, we sequenced >70 genes from 191 autopsy-negative SUDI victims. Ten infants sharing a previously unknown variant in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720d324560e0405da37ed8b963a3233d
https://europepmc.org/articles/PMC6452669/
https://europepmc.org/articles/PMC6452669/
Autor:
Charles M. Stevens, Thambirajah Balachandra, Susan M. Phillips, Sanam Shafaatalab, Luisa D’Amato, Miguel Alcaide, Laura J. Dewar, Glen F. Tibbits, Daniel Fornika, Ryan D. Morin, Shubhayan Sanatani
Publikováno v:
Circulation: Cardiovascular Genetics. 10
Background— Inherited arrhythmia syndromes are responsible for a significant portion of autopsy-negative sudden unexpected death (SUD) cases, but molecular autopsy used to identify potentially causal variants is not routinely included in SUD invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3116ea3bc4922c2146cfe5aebf9f29a4
https://doi.org/10.1161/circgenetics.116.001738
https://doi.org/10.1161/circgenetics.116.001738
Autor:
Charles M, Stevens, Kaveh, Rayani, Gurpreet, Singh, Bairam, Lotfalisalmasi, D Peter, Tieleman, Glen F, Tibbits
Publikováno v:
The Journal of biological chemistry. 292(28)
Cardiac troponin C (cTnC) is the regulatory protein that initiates cardiac contraction in response to Ca2+. TnC binding Ca2+ initiates a cascade of protein–protein interactions that begins with the opening of the N-terminal domain of cTnC, followed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2c054c2d21ef1a07721f2ce625e8946
https://pubmed.ncbi.nlm.nih.gov/28533433
https://pubmed.ncbi.nlm.nih.gov/28533433
Autor:
Christine E, Genge, Eric, Lin, Ling, Lee, XiaoYe, Sheng, Kaveh, Rayani, Marvin, Gunawan, Charles M, Stevens, Alison Yueh, Li, Sanam Shafaat, Talab, Thomas W, Claydon, Leif, Hove-Madsen, Glen F, Tibbits
Publikováno v:
Reviews of physiology, biochemistry and pharmacology. 171
Zebrafish (Danio rerio) are widely used as vertebrate model in developmental genetics and functional genomics as well as in cardiac structure-function studies. The zebrafish heart has been increasingly used as a model of human cardiac function, in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::115165cdaf36079866e0b69835975141
https://pubmed.ncbi.nlm.nih.gov/27538987
https://pubmed.ncbi.nlm.nih.gov/27538987
Autor:
Charles M. Stevens, Christine E. Genge, D. Peter Tieleman, Glen F. Tibbits, Gurpreet Singh, William S. Davidson
Publikováno v:
Genome Biology and Evolution
Gene duplication results in extra copies of genes that must coevolve with their interacting partners in multimeric protein complexes. The cardiac troponin (Tn) complex, containing TnC, TnI, and TnT, forms a distinct functional unit critical for the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08114b86d256d7aaf7ea78485b42afa4
https://pubmed.ncbi.nlm.nih.gov/26979795
https://pubmed.ncbi.nlm.nih.gov/26979795
Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC
Autor:
Gurpreet Singh, Cindy Li, Charles M. Stevens, Kaveh Rayani, Glen F. Tibbits, Filip Van Petegem, Bo Liang, Christine E. Genge, Janine M. Roller, Alison Yueh Li, D. Peter Tieleman
Publikováno v:
Biophysical journal. 111(1)
Zebrafish, as a model for teleost fish, have two paralogous troponin C (TnC) genes that are expressed in the heart differentially in response to temperature acclimation. Upon Ca(2+) binding, TnC changes conformation and exposes a hydrophobic patch th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a15ff33e1755b4143ca8031424f0b9e
https://pubmed.ncbi.nlm.nih.gov/27410732
https://pubmed.ncbi.nlm.nih.gov/27410732
Publikováno v:
Biophysical Journal. 110(3)
Interaction of calcium Ca2+ and troponin C (TnC) is a fundamental process governing regulation of cardiac contractility. Increased affinity of cTnC's regulatory site II for Ca2+ elevates sensitivity, leading to greater force production capabilities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caff36ef7fc6b1000dd6e0ff77a13bfc
Autor:
Ling Lee, Christine E. Genge, Marvin Gunawan, Alison Yueh Li, Glen F. Tibbits, Leif Hove-Madsen, Sanam Shafaat Talab, Thomas W. Claydon, Kaveh Rayani, Eric Lin, Xiaoye Sheng, Charles M. Stevens
Publikováno v:
Reviews of Physiology, Biochemistry and Pharmacology ISBN: 9783319438139
Zebrafish (Danio rerio) are widely used as vertebrate model in developmental genetics and functional genomics as well as in cardiac structure-function studies. The zebrafish heart has been increasingly used as a model of human cardiac function, in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f633388e69be65ea5311d3848c9af6de
https://doi.org/10.1007/112_2016_5
https://doi.org/10.1007/112_2016_5