Genomic profiling of a randomized trial of interferon-α vs hydroxyurea in MPN reveals mutation-specific responses

Autor: R. Coleman Lindsley, Thomas Kielsgaard Kristensen, Mette Brabrand, Mads Thomassen, Charles Laurore, Jesper Stentoft, Christina Ellervik, Ann Mullally, Donna Neuberg, Lukas Frans Ocias, Daniel El Fassi, Karin de Stricker, William Duke, Anwesha Nag, Christopher J. Gibson, Marianne Tang Severinsen, Torben A Kruse, Lillian Werner, Torben Mourits-Andersen, Mikael Frederiksen, Trine Alma Knudsen, Thomas Stauffer Larsen, Aaron R. Thorner, Ulrik Malthe Overgaard, Dennis Lund Hansen, Bruce M. Wollison, Vibe Skov, Lasse Kjær, Joern Starklint, Kristen E. Stevenson, Ole Weis Bjerrum, Hans Carl Hasselbalch

Publikováno v: Knudsen, T A, Skov, V, Stevenson, K E, Werner, L, Duke, W, Laurore, C, Gibson, C J, Nag, A, Thorner, A R, Wollison, B, Hansen, D L, Ellervik, C, El Fassi, D, de Stricker, K, Ocias, L F, Brabrand, M, Bjerrum, O W, Overgaard, U, Frederiksen, M, Kristensen, T, Kruse, T, Thomassen, M, Mourits-Andersen, T, Severinsen, M T, Stentoft, J, Starklint, J, Neuberg, D, Kjaer, L, Larsen, T S, Hasselbalch, H C, Lindsley, R C & Mullally, A 2022, ' Genomic profiling of a randomized trial of interferon-α vs hydroxyurea in MPN reveals mutation-specific responses ', Blood Advances, vol. 6, no. 7, pp. 2107-2119 . https://doi.org/10.1182/bloodadvances.2021004856
Knudsen, T A, Skov, V, Stevenson, K E, Werner, L, Duke, W, Laurore, C, Gibson, C J, Nag, A, Thorner, A R, Wollison, B, Hansen, D L, Ellervik, C, El Fassi, D, de Stricker, K, Ocias, L F, Brabrand, M, Bjerrum, O W, Overgaard, U M, Frederiksen, M, Kristensen, T K, Kruse, T A, Thomassen, M, Mourits-Andersen, T, Severinsen, M T, Stentoft, J, Starklint, J, Neuberg, D S, Kjaer, L, Larsen, T S, Hasselbalch, H C, Lindsley, R C & Mullally, A 2022, ' Genomic Profiling of a Randomized Trial of Interferon-α versus Hydroxyurea in MPN Reveals Mutation-Specific Responses ', Blood advances, vol. 6, no. 7, pp. 2107–2119 . https://doi.org/10.1182/bloodadvances.2021004856
Knudsen, T A, Skov, V, Stevenson, K, Werner, L, Duke, W, Laurore, C, Gibson, C J, Nag, A, Thorner, A R, Wollison, B, Hansen, D L, Ellervik, C, Fassi, D E, de Stricker, K, Ocias, L F, Brabrand, M, Bjerrum, O W, Overgaard, U M, Frederiksen, M, Kristensen, T K, Kruse, T A, Thomassen, M, Mourits-Andersen, T, Severinsen, M T, Stentoft, J, Starklint, J, Neuberg, D S, Kjaer, L, Larsen, T S, Hasselbalch, H C, Lindsley, R C & Mullally, A 2022, ' Genomic profiling of a randomized trial of interferon-a vs hydroxyurea in MPN reveals mutation-specific responses ', Blood advances, vol. 6, no. 7, pp. 2107-2119 . https://doi.org/10.1182/bloodadvances.2021004856
Knudsen, T A, Skov, V, Stevenson, K, Werner, L, Duke, W, Laurore, C, Gibson, C J, Nag, A, Thorner, A R, Wollison, B, Hansen, D L, Ellervik, C, Fassi, D E, de Stricker, K, Ocias, L F, Brabrand, M, Bjerrum, O W, Overgaard, U M, Frederiksen, M, Kristensen, T K, Kruse, T A, Thomassen, M, Mourits-Andersen, T, Severinsen, M T, Stentoft, J, Starklint, J, Neuberg, D S, Kjaer, L, Larsen, T S, Hasselbalch, H C, Lindsley, R C & Mullally, A 2022, ' Genomic profiling of a randomized trial of interferon-a vs hydroxyurea in MPN reveals mutation-specific responses ', Blood Advances, vol. 6, no. 7, pp. 2107-2119 . https://doi.org/10.1182/bloodadvances.2021004856

Although somatic mutations influence the pathogenesis, phenotype, and outcome of myeloproliferative neoplasms (MPNs), little is known about their impact on molecular response to cytoreductive treatment. We performed targeted next-generation sequencin

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