Zobrazeno 1 - 10
of 220
pro vyhledávání: '"Charles L. Limoli"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The rapidly evolving field of radiomics has shown that radiomic features are able to capture characteristics of both tumor and normal tissue that can be used to make accurate and clinically relevant predictions. In the present study we sough
Externí odkaz:
https://doaj.org/article/a7e5d148b12747e1917efc0d57cd9ec1
Autor:
Sarah M. Smith, Kashvi Ranjan, Brianna M. Hoover, Olivia G. G. Drayson, Munjal M. Acharya, Eniko A. Kramár, Janet E. Baulch, Charles L. Limoli
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Cranial irradiation used to control brain malignancies invariably leads to progressive and debilitating declines in cognition. Clinical efforts implementing hippocampal avoidance and NMDAR antagonism, have sought to minimize dose to radiosen
Externí odkaz:
https://doaj.org/article/c24f839ae44e482f9f1aa52934656cd5
Autor:
Rajeev I. Desai, Brian D. Kangas, Oanh T. Luc, Eleana Solakidou, Evan C. Smith, Monica H. Dawes, Xiaoyu Ma, Alexandros Makriyannis, Subhamoy Chatterjee, Maher A. Dayeh, Andrés Muñoz-Jaramillo, Mihir I. Desai, Charles L. Limoli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Astronauts will encounter extended exposure to galactic cosmic radiation (GCR) during deep space exploration, which could impair brain function. Here, we report that in male mice, acute or chronic GCR exposure did not modify reward sensitivi
Externí odkaz:
https://doaj.org/article/573859978f494166b0188516beef21cd
Autor:
Richard A. Britten, Charles L. Limoli
Publikováno v:
Life, Vol 13, Iss 6, p 1293 (2023)
Traditionally, the brain has been regarded as a relatively insensitive late-reacting tissue, with radiologically detectable damage not being reported at doses < 60 Gy. When NASA proposed interplanetary exploration missions, it was required to conduct
Externí odkaz:
https://doaj.org/article/ed81c717de974c57ac5b906b6c7b34fa
Autor:
Nina A. Mayr, MD, James W. Snider, MD, William F. Regine, MD, Majid Mohiuddin, MD, Daniel S. Hippe, MS, José Peñagarícano, MD, Mohammed Mohiuddin, MD, Mahesh R. Kudrimoti, MD, Hualin Zhang, PhD, Charles L. Limoli, PhD, Quynh-Thu Le, MD, Charles B. Simone, II, MD
Publikováno v:
Advances in Radiation Oncology, Vol 7, Iss 2, Pp 100866- (2022)
Purpose: Spatially fractionated radiation therapy (SFRT), which delivers highly nonuniform dose distributions instead of conventionally practiced homogeneous tumor dose, has shown high rates of clinical response with minimal toxicities in large-volum
Externí odkaz:
https://doaj.org/article/fb8222bdef25424f9070c74caa5f822b
Autor:
Barrett D. Allen, Amber R. Syage, Mattia Maroso, Al Anoud D. Baddour, Valerie Luong, Harutyun Minasyan, Erich Giedzinski, Brian L. West, Ivan Soltesz, Charles L. Limoli, Janet E. Baulch, Munjal M. Acharya
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-18 (2020)
Abstract Background Cosmic radiation exposures have been found to elicit cognitive impairments involving a wide-range of underlying neuropathology including elevated oxidative stress, neural stem cell loss, and compromised neuronal architecture. Cogn
Externí odkaz:
https://doaj.org/article/3b4ea0deb00c444bb7cfbacfe3de9993
Autor:
Sarah M. Smith, Erich Giedzinski, Maria C. Angulo, Tiffany Lui, Celine Lu, Audrey L. Park, Sharon Tang, Vahan Martirosian, Ning Ru, Nicole N. Chmielewski, Yaxuan Liang, Janet E. Baulch, Munjal M. Acharya, Charles L. Limoli
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 1, Pp 93-105 (2020)
Abstract Cranial radiotherapy, although beneficial for the treatment of brain tumors, inevitably leads to normal tissue damage that can induce unintended neurocognitive complications that are progressive and debilitating. Ionizing radiation exposure
Externí odkaz:
https://doaj.org/article/db9672fadae3442e98cea361349d5c37
Autor:
Vipan K. Parihar, Amber Syage, Lidia Flores, Angelica Lilagan, Barrett D. Allen, Maria C. Angulo, Joseph Song, Sarah M. Smith, Rebecca J. Arechavala, Erich Giedzinski, Charles L. Limoli
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Despite advancements in the radiotherapeutic management of brain malignancies, resultant sequelae include persistent cognitive dysfunction in the majority of survivors. Defining the precise causes of normal tissue toxicity has proven challenging, but
Externí odkaz:
https://doaj.org/article/a07efe91c2714ee2a2f4fff50b9ffa26
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Externí odkaz:
https://doaj.org/article/72da07fe61d84df9aa77db0cd82a1496
Autor:
Peter M. Klein, Vipan K. Parihar, Gergely G. Szabo, Miklós Zöldi, Maria C. Angulo, Barrett D. Allen, Amal N. Amin, Quynh-Anh Nguyen, István Katona, Janet E. Baulch, Charles L. Limoli, Ivan Soltesz
Publikováno v:
Neurobiology of Disease, Vol 151, Iss , Pp 105252- (2021)
Galactic cosmic radiation (GCR), composed of highly energetic and fully ionized atomic nuclei, produces diverse deleterious effects on the body. In researching the neurological risks of GCR exposures, including during human spaceflight, various groun
Externí odkaz:
https://doaj.org/article/a66003fda2bc4ad48eb746cea77b12ee