Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Charles L. Howe"'
Autor:
Charles L. Howe, Renee K. Johnson, Brittany L. Overlee, Jessica A. Sagen, Niyati Mehta, Raquel Farias‐Moeller
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 5, Pp 719-731 (2023)
Abstract Objective Therapeutic strategies for patients with febrile infection‐related epilepsy syndrome (FIRES) are limited, ad hoc, and frequently ineffective. Based on evidence that inflammation drives pathogenesis in FIRES, we used ex vivo stimu
Externí odkaz:
https://doaj.org/article/6957790a93014c7198cf50424774a199
Autor:
Benjamin D.S. Clarkson, Ethan M. Grund, Miranda M. Standiford, Kanish Mirchia, Maria S. Westphal, Liz S. Muschler, Charles L. Howe
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
CD8+ T cells outnumber CD4+ cells in multiple sclerosis (MS) lesions associated with disease progression, but the pathogenic role and antigenic targets of these clonally expanded effectors are unknown. Based on evidence that demyelination is necessar
Externí odkaz:
https://doaj.org/article/d3e995d405734c7cb2114fe8c13949a4
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Same day processing of biospecimens such as blood is not always feasible, which presents a challenge for research programs seeking to study a broad population or to characterize patients with rare diseases. Recruiting sites may not be equipp
Externí odkaz:
https://doaj.org/article/598190a1f3f9485dba6dbf22b218ad14
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-23 (2022)
Abstract The causes of grey matter pathology and diffuse neuron injury in MS remain incompletely understood. Axonal stress signals arising from white matter lesions has been suggested to play a role in initiating this diffuse grey matter pathology. T
Externí odkaz:
https://doaj.org/article/a46d531f7ce247d99dcf9b3fff91ab9a
Autor:
Xu Zhang, Vesselina M. Pearsall, Chase M. Carver, Elizabeth J. Atkinson, Benjamin D. S. Clarkson, Ethan M. Grund, Michelle Baez-Faria, Kevin D. Pavelko, Jennifer M. Kachergus, Thomas A. White, Renee K. Johnson, Courtney S. Malo, Alan M. Gonzalez-Suarez, Katayoun Ayasoufi, Kurt O. Johnson, Zachariah P. Tritz, Cori E. Fain, Roman H. Khadka, Mikolaj Ogrodnik, Diana Jurk, Yi Zhu, Tamara Tchkonia, Alexander Revzin, James L. Kirkland, Aaron J. Johnson, Charles L. Howe, E. Aubrey Thompson, Nathan K. LeBrasseur, Marissa J. Schafer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The authors discovered that proinflammatory senescent myeloid cells may recruit peripheral immune cells in the aged mouse brain. Their findings implicate senescent cell clearance as a strategy to counter aged brain inflammation and cognitive decline.
Externí odkaz:
https://doaj.org/article/563782268a174f9491ef229d9fd5e5e9
Autor:
Parijat Kabiraj, Ethan M. Grund, Benjamin D. S. Clarkson, Renee K. Johnson, Reghann G. LaFrance-Corey, Claudia F. Lucchinetti, Charles L. Howe
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Astrocytes utilize both glycolytic and mitochondrial pathways to power cellular processes that are vital to maintaining normal CNS functions. These cells also mount inflammatory and acute phase reactive programs in response to diverse stimul
Externí odkaz:
https://doaj.org/article/6082d9204e764fd28bf335baa7845997
Autor:
Charles L. Howe, Reghann G. LaFrance-Corey, Brittany L. Overlee, Renee K. Johnson, Benjamin D. S. Clarkson, Emma N. Goddery
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background The pathogenic contribution of neuroinflammation to ictogenesis and epilepsy may provide a therapeutic target for reduction of seizure burden in patients that are currently underserved by traditional anti-seizure medications. The
Externí odkaz:
https://doaj.org/article/36d646d746d34492ad1f55df48b32c7d
Autor:
Luke A. Stangler, Abbas Kouzani, Kevin E. Bennet, Ludovic Dumee, Michael Berk, Gregory A. Worrell, Steven Steele, Terence C. Burns, Charles L. Howe
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-14 (2021)
Abstract Contemporary biomarker collection techniques in blood and cerebrospinal fluid have to date offered only modest clinical insights into neurologic diseases such as epilepsy and glioma. Conversely, the collection of human electroencephalography
Externí odkaz:
https://doaj.org/article/d578ea0139c443eea743608ea0f77802
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)
Abstract Background Microglia are the primary phagocytes of the central nervous system and are responsible for removing damaged myelin following demyelination. Previous investigations exploring the consequences of myelin phagocytosis on microglial ac
Externí odkaz:
https://doaj.org/article/51cf6a9e5ba6479ca532c06010660dc7
Autor:
Wolfgang Löscher, Charles L. Howe
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Seizures are a common presenting symptom during viral infections of the central nervous system (CNS) and can occur during the initial phase of infection (“early” or acute symptomatic seizures), after recovery (“late” or spontaneous seizures,
Externí odkaz:
https://doaj.org/article/5c0ed97203a24c27961e852e0ea593b3