Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Charles L. Densmore"'
Publikováno v:
American Journal of Respiratory Medicine
Delivery of therapeutic genes to the lungs is an attractive strategy to correct a variety of pulmonary dysfunctions such as cystic fibrosis, alpha-1 antitrypsin deficiency, pulmonary hypertension, asthma, and lung cancer. Different delivery routes su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a72c39b2ce6111682134f7f2b71594
http://europepmc.org/articles/PMC7102356
http://europepmc.org/articles/PMC7102356
Autor:
Berma M. Kinsey, Frank M. Orson, Philip R. Wyde, Yan Wu, Innocent N. Mbawuike, Tina Nguyen, Charles L. Densmore
Publikováno v:
The Journal of Gene Medicine. 8:488-497
Background Conventional vaccine development for newly emerging pandemic influenza virus strains would likely take too long to prevent devastating global morbidity and mortality. If DNA vaccines can be distributed and delivered efficiently, genetic im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0d9f982373e8c5dc660f48213b8892
https://doi.org/10.1002/jgm.864
https://doi.org/10.1002/jgm.864
Publikováno v:
Current Gene Therapy. 5:181-194
The lung represents an important target for gene therapy: for correction of genetic abnormalities such as cystic fibrosis, for lung cancer therapy, and for vaccination. Genes in the form of expression plasmids can be delivered both by the intravenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ba138d4198cbc16cc88629474127ae
https://doi.org/10.2174/1566523053544254
https://doi.org/10.2174/1566523053544254
Autor:
Charles L. Densmore
Publikováno v:
Expert Opinion on Biological Therapy. 3:1083-1092
The delivery of genes by inhalation holds promise for the treatment of a wide range of pulmonary and non-pulmonary disorders and offers numerous advantages over more invasive modes of delivery. Subsequent to the cloning of the cystic fibrosis gene, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b6b04389e21f94f0231db20876ffa3b
https://doi.org/10.1517/14712598.3.7.1083
https://doi.org/10.1517/14712598.3.7.1083
Autor:
Brian E. Gilbert, Luz Roberts, Charles L. Densmore, J.C. Waldrep, Vernon Knight, Nadezhda V. Koshkina, Ajay Gautam, Sara Melton
Publikováno v:
Gene Therapy. 9:353-357
Growth inhibition of established tumor metastases in the lungs poses a difficult challenge for most clinical settings in spite of extensive multi-modality approaches. Aerosol delivery of drugs and genes holds promise for the treatment of disseminated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd7a47e5aa2495f2b5d363e014c947a9
https://doi.org/10.1038/sj.gt.3301662
https://doi.org/10.1038/sj.gt.3301662
Autor:
Laura L. Worth, Vernon Knight, Charles L. Densmore, Ajay Gautam, Yuen Kai Fung, Eugenie S. Kleinerman, J. Clifford Waldrep, Bo Xu, Anne T'ang, Shu Fang Jia
Publikováno v:
Cancer Gene Therapy. 8:619-627
Lung metastases are a frequent complication of osteosarcoma and a treatment that would reduce the severity of this complication would be of great benefit to patients. We have used a formulation consisting of polyethyleneimine (PEI) and a p53 gene adm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8d6c5f48155e777227f775b6682b43
https://doi.org/10.1038/sj.cgt.7700343
https://doi.org/10.1038/sj.cgt.7700343
Publikováno v:
Molecular Therapy. 3(4):551-556
Gene therapy targeted at the respiratory epithelium holds therapeutic potential for diseases such as cystic fibrosis and α-1 anti-trypsin deficiency. A variety of approaches such as intranasal or intratracheal instillation and aerosol delivery have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f56c282d2a1b7d9e44b8d4b2e5a266
Publikováno v:
Molecular Therapy. 2(4):318-323
Mutations in the p53 tumor suppressor gene and the pathways mediated by the p53 protein are common in many human cancers. Replacement of functional p53 by gene therapy is a potential way of combating these cancers and the associated drug resistance a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d135e2c65a36b6f897460aa5521472
Publikováno v:
Molecular Therapy. 2:63-70
Aerosol gene delivery to the pulmonary system has vast potential for many diseases, including cystic fibrosis and lung cancer. We recently reported that polyethyleneimine (PEI), a cationic polymer, holds promise as a gene delivery vector for transfec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009823ca0bc3d6fd358656710ab7362a
https://doi.org/10.1006/mthe.2000.0087
https://doi.org/10.1006/mthe.2000.0087
Autor:
Balbir Bhogal, Bo Xu, Frank M. Orson, Pascal Hua, Berma M. Kinsey, J. Clifford Waldrep, Vernon Knight, Charles L. Densmore
Publikováno v:
Molecular Therapy. 1(2):180-188
Aerosol delivery of plasmid DNA to the lungs offers the possibility of direct application of gene preparations to pulmonary surfaces as a means of treating a variety of genetic pulmonary disorders. However, the process of jet nebulization rapidly deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5cd1d2a6c89ab55dd9e1b6c844b75c3