Zobrazeno 1 - 10
of 427
pro vyhledávání: '"Charles L. Hoppel"'
Autor:
Wagner S. Dantas, Elizabeth R.M. Zunica, Elizabeth C. Heintz, Bolormaa Vandanmagsar, Z. Elizabeth Floyd, Yongmei Yu, Hisashi Fujioka, Charles L. Hoppel, Kathryn P. Belmont, Christopher L. Axelrod, John P. Kirwan
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 3, Pp 1821-1836 (2022)
Abstract Background Sarcopenic obesity is a highly prevalent disease with poor survival and ineffective medical interventions. Mitochondrial dysfunction is purported to be central in the pathogenesis of sarcopenic obesity by impairing both organelle
Externí odkaz:
https://doaj.org/article/04ea9ee21dc2491bba4d381201f55dcb
Autor:
Elizabeth O. Akinbiyi, Lara K. Abramowitz, Brianna L. Bauer, Maria S. K. Stoll, Charles L. Hoppel, Chao-Pin Hsiao, John A. Hanover, Jason A. Mears
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract O-GlcNAcylation is a prevalent form of glycosylation that regulates proteins within the cytosol, nucleus, and mitochondria. The O-GlcNAc modification can affect protein cellular localization, function, and signaling interactions. The specifi
Externí odkaz:
https://doaj.org/article/9048e2672c6344cea6e502b9ebc484a0
Autor:
Elizabeth R. M. Zunica, Christopher L. Axelrod, Eunhan Cho, Guillaume Spielmann, Gangarao Davuluri, Stephanie J. Alexopoulos, Martina Beretta, Kyle L. Hoehn, Wagner S. Dantas, Krisztian Stadler, William T. King, Kathryn Pergola, Brian A. Irving, Ingeborg M. Langohr, Shengping Yang, Charles L. Hoppel, L. Anne Gilmore, John P. Kirwan
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-20 (2021)
Abstract Background Enhanced metabolic plasticity and diversification of energy production is a hallmark of highly proliferative breast cancers. This contributes to poor pharmacotherapy efficacy, recurrence, and metastases. We have previously identif
Externí odkaz:
https://doaj.org/article/73646908050a40a890022b3871277182
Autor:
Junhwan Kim, Charles L. Hoppel
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 12, Pp 1707-1719 (2020)
Phospholipids, including ether phospholipids, are composed of numerous isomeric and isobaric species that have the same backbone and acyl chains. This structural resemblance results in similar fragmentation patterns by collision-induced dissociation
Externí odkaz:
https://doaj.org/article/8b047f209cfe4677b69f3988f3eb3661
Autor:
Christopher L Axelrod, William T King, Gangarao Davuluri, Robert C Noland, Jacob Hall, Michaela Hull, Wagner S Dantas, Elizabeth RM Zunica, Stephanie J Alexopoulos, Kyle L Hoehn, Ingeborg Langohr, Krisztian Stadler, Haylee Doyle, Eva Schmidt, Stephan Nieuwoudt, Kelly Fitzgerald, Kathryn Pergola, Hisashi Fujioka, Jacob T Mey, Ciaran Fealy, Anny Mulya, Robbie Beyl, Charles L Hoppel, John P Kirwan
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 7, Pp 1-20 (2020)
Abstract Obesity is a leading cause of preventable death worldwide. Despite this, current strategies for the treatment of obesity remain ineffective at achieving long‐term weight control. This is due, in part, to difficulties in identifying tolerab
Externí odkaz:
https://doaj.org/article/61fe5cb6b2dd4631b169f643148abc19
Autor:
Jirair K. Bedoyan, Leah Hecht, Shulin Zhang, Stacey Tarrant, Ann Bergin, Didem Demirbas, Edward Yang, Ha Kyung Shin, George J. Grahame, Suzanne D. DeBrosse, Charles L. Hoppel, Douglas S. Kerr, Gerard T. Berry
Publikováno v:
JIMD Reports, Vol 48, Iss 1, Pp 26-35 (2019)
Abstract Congenital lactic acidosis due to pyruvate dehydrogenase phosphatase (PDP) deficiency is very rare. PDP regulates pyruvate dehydrogenase complex (PDC) and defective PDP leads to PDC deficiency. We report a case with functional PDC deficiency
Externí odkaz:
https://doaj.org/article/b59d2924e8ea4aa7970c206f3ceba207
Autor:
Dmitry Grapov, Oliver Fiehn, Caitlin Campbell, Carol J. Chandler, Dustin J. Burnett, Elaine C. Souza, Gretchen A. Casazza, Nancy L. Keim, Gary R. Hunter, Jose R. Fernandez, W. Timothy Garvey, Charles L. Hoppel, Mary‐Ellen Harper, John W. Newman, Sean H. Adams
Publikováno v:
Physiological Reports, Vol 8, Iss 17, Pp n/a-n/a (2020)
Abstract Very little is known about how metabolic health status, insulin resistance or metabolic challenges modulate the endocannabinoid (eCB) or polyunsaturated fatty acid (PUFA)‐derived oxylipin (OxL) lipid classes. To address these questions, pl
Externí odkaz:
https://doaj.org/article/f939dd25011c4530ad740512e0645637
Autor:
Nicola Lai, Ciarán E. Fealy, Chinna M. Kummitha, Silvia Cabras, John P. Kirwan, Charles L. Hoppel
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
AimInsulin-resistant skeletal muscle is characterized by metabolic inflexibility with associated alterations in substrate selection, mediated by peroxisome-proliferator activated receptor δ (PPARδ). Although it is established that PPARδ contribute
Externí odkaz:
https://doaj.org/article/dc9dec63b9e244259ddc6a5570ef646c
Autor:
Weinan Du, Luchang Zhang, Adina Brett-Morris, Brittany Aguila, Janos Kerner, Charles L. Hoppel, Michelle Puchowicz, Dolors Serra, Laura Herrero, Brian I. Rini, Steven Campbell, Scott M. Welford
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Clear cell renal cancers (ccRCC) display elevated intracellular lipid storage. Here the authors show that such lipid accumulation is due to the repression of carnitine palmitoyltransferase 1A (CPT1A) enzyme that impairs fatty acid (FA) transport into
Externí odkaz:
https://doaj.org/article/cc5068c04902403e806e57ccd56d51a2
Autor:
Saurabh Mishra, Nicole Welch, Manikandan Karthikeyan, Annette Bellar, Ryan Musich, Shashi Shekhar Singh, Dongmei Zhang, Jinendiran Sekar, Amy H. Attaway, Aruna Kumar Chelluboyina, Shuhui Wang Lorkowski, Sanjoy Roychowdhury, Ling Li, Belinda Willard, Jonathan D. Smith, Charles L. Hoppel, Vidula Vachharajani, Avinash Kumar, Srinivasan Dasarathy
Publikováno v:
Aging Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::facd9d55f010b78d202ae2d7d15b87cf
https://doi.org/10.1111/acel.13852
https://doi.org/10.1111/acel.13852