Zobrazeno 1 - 10
of 464
pro vyhledávání: '"Charles L Sawyers"'
Autor:
Eugine Lee, John Wongvipat, Danielle Choi, Ping Wang, Young Sun Lee, Deyou Zheng, Philip A Watson, Anuradha Gopalan, Charles L Sawyers
Publikováno v:
eLife, Vol 8 (2019)
Genomic amplification of the androgen receptor (AR) is an established mechanism of antiandrogen resistance in prostate cancer. Here, we show that the magnitude of AR signaling output, independent of AR genomic alteration or expression level, also con
Externí odkaz:
https://doaj.org/article/a9ce9b1a721845688d664f179362cf94
Autor:
Haley Hieronymus, Rajmohan Murali, Amy Tin, Kamlesh Yadav, Wassim Abida, Henrik Moller, Daniel Berney, Howard Scher, Brett Carver, Peter Scardino, Nikolaus Schultz, Barry Taylor, Andrew Vickers, Jack Cuzick, Charles L Sawyers
Publikováno v:
eLife, Vol 7 (2018)
The level of copy number alteration (CNA), termed CNA burden, in the tumor genome is associated with recurrence of primary prostate cancer. Whether CNA burden is associated with prostate cancer survival or outcomes in other cancers is unknown. We ana
Externí odkaz:
https://doaj.org/article/9bb98e789ff74231b7de3a9771793c64
Publikováno v:
eLife, Vol 7 (2018)
More than 30 published articles have suggested that a protein kinase called MELK is an attractive therapeutic target in human cancer, but three recent reports describe compelling evidence that it is not. These reports highlight the caveats associated
Externí odkaz:
https://doaj.org/article/9eaea52901184caf9e0d6330164d0f41
Autor:
Neel Shah, Ping Wang, John Wongvipat, Wouter R Karthaus, Wassim Abida, Joshua Armenia, Shira Rockowitz, Yotam Drier, Bradley E Bernstein, Henry W Long, Matthew L Freedman, Vivek K Arora, Deyou Zheng, Charles L Sawyers
Publikováno v:
eLife, Vol 6 (2017)
In prostate cancer, resistance to the antiandrogen enzalutamide (Enz) can occur through bypass of androgen receptor (AR) blockade by the glucocorticoid receptor (GR). In contrast to fixed genomic alterations, here we show that GR-mediated antiandroge
Externí odkaz:
https://doaj.org/article/61db683fcfe74955afcc80092315405e
Autor:
Dong Gao, Yu Zhan, Wei Di, Amanda R Moore, Jessica J Sher, Youxin Guan, Shangqian Wang, Zeda Zhang, Devan A Murphy, Charles L Sawyers, Ping Chi, Yu Chen
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161084 (2016)
Fusion between TMPRSS2 and ERG, placing ERG under the control of the TMPRSS2 promoter, is the most frequent genetic alteration in prostate cancer, present in 40-50% of cases. The fusion event is an early, if not initiating, event in prostate cancer,
Externí odkaz:
https://doaj.org/article/c7848b1536d844d4976f31c6711bd4ab
Autor:
Azra Ajkunic, Erolcan Sayar, Martine P. Roudier, Radhika A. Patel, Ilsa M. Coleman, Navonil De Sarkar, Brian Hanratty, Mohamed Adil, Jimmy Zhao, Samir Zaidi, Lawrence D. True, Jamie M. Sperger, Heather H. Cheng, Evan Y. Yu, Robert B. Montgomery, Jessica E. Hawley, Gavin Ha, Thomas Persse, Patricia Galipeau, John K. Lee, Stephanie A. Harmon, Eva Corey, Joshua M. Lang, Charles L. Sawyers, Colm Morrissey, Michael T. Schweizer, Roman Gulati, Peter S. Nelson, Michael C. Haffner
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-9 (2024)
Abstract Therapeutic approaches targeting proteins on the surface of cancer cells have emerged as an important strategy for precision oncology. To capitalize on the potential impact of drugs targeting surface proteins, detailed knowledge about the ex
Externí odkaz:
https://doaj.org/article/cdd085eaf0e84556a25f843f3b873e3c
Autor:
Ulrik Ringborg, Joachim vonBraun, Julio Celis, Michael Baumann, Anton Berns, Alexander Eggermont, Edith Heard, Manuel Heitor, Mammen Chandy, Chien‐Jen Chen, Alberto Costa, Francesco De Lorenzo, Edward M. De Robertis, Frederick Charles Dubee, Ingemar Ernberg, Mariya Gabriel, Åslaug Helland, Rui Henrique, Bengt Jönsson, Olli Kallioniemi, Jan Korbel, Mechthild Krause, Douglas R. Lowy, Olivier Michielin, Peter Nagy, Simon Oberst, Vincenzo Paglia, M. Iqbal Parker, Kevin Ryan, Charles L. Sawyers, Joachim Schüz, Katherine Silkaitis, Eric Solary, David Thomas, Peter Turkson, Elisabete Weiderpass, Huanming Yang
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 245-279 (2024)
Analyses of inequalities related to prevention and cancer therapeutics/care show disparities between countries with different economic standing, and within countries with high Gross Domestic Product. The development of basic technological and biologi
Externí odkaz:
https://doaj.org/article/aed58f51906b40f3875630c0b7d33c89
Autor:
Minna D Balbas, Michael J Evans, David J Hosfield, John Wongvipat, Vivek K Arora, Philip A Watson, Yu Chen, Geoffrey L Greene, Yang Shen, Charles L Sawyers
Publikováno v:
eLife, Vol 2 (2013)
The second-generation antiandrogen enzalutamide was recently approved for patients with castration-resistant prostate cancer. Despite its success, the duration of response is often limited. For previous antiandrogens, one mechanism of resistance is m
Externí odkaz:
https://doaj.org/article/5cc24901b9144dda9e4dbe5d14cea6af
Autor:
Kimberly Brown Dahlman, Joel S Parker, Tambudzai Shamu, Haley Hieronymus, Caren Chapinski, Brett Carver, Kenneth Chang, Gregory J Hannon, Charles L Sawyers
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34414 (2012)
There is significant need to identify novel prostate cancer drug targets because current hormone therapies eventually fail, leading to a drug-resistant and fatal disease termed castration-resistant prostate cancer. To functionally identify genes that
Externí odkaz:
https://doaj.org/article/c5eba6ffb78743f39e66e0dda022b279
Autor:
Nicola J Clegg, Suzana S Couto, John Wongvipat, Haley Hieronymus, Brett S Carver, Barry S Taylor, Katharine Ellwood-Yen, William L Gerald, Chris Sander, Charles L Sawyers
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17449 (2011)
MYC and phosphoinositide 3-kinase (PI3K)-pathway deregulation are common in human prostate cancer. Through examination of 194 human prostate tumors, we observed statistically significant co-occurrence of MYC amplification and PI3K-pathway alteration,
Externí odkaz:
https://doaj.org/article/f7ac97a4d65f4edb91d42d10dfb6c26d