Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Charles Kunsch"'
Autor:
Todd Holscher, Nigel Mackman, K. Veera Reddy, Rong Zhang, Michael Tencati, J. Daniel Piper, Charles Kunsch, Xi Lin Chen, Jayraz Luchoomun, Wang Min, James P. Luyendyk
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 27:1857-1863
Objective— Oxidative stress contributes to the pathogenesis of many diseases, including atherosclerosis and sepsis. We have previously described a novel class of therapeutic compounds with antioxidant and antiinflammatory properties. However, at pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c1f796ae0a4c4655726f1f7b799f35
https://doi.org/10.1161/atvbaha.107.143552
https://doi.org/10.1161/atvbaha.107.143552
Autor:
David G. Edwards, Charles Q. Meng, Charles Kunsch, Russell M. Medford, Martin A. Wasserman, Cynthia L. Sundell
Publikováno v:
The American Journal of Cardiology. 91:34-40
This review addresses the role of oxidative stress in the pathology of atherosclerosis and why it is now believed that atherosclerosis is not only a disease of oxidative stress but also of chronic inflammation. Perhaps more importantly, this review a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b51bbb2f845e467e5e665569e0ae120
https://doi.org/10.1016/s0002-9149(02)03148-x
https://doi.org/10.1016/s0002-9149(02)03148-x
Publikováno v:
Experimental Cell Research. 257:310-319
The mammalian gamma subunit family consists of a minimum of 12 members. Analysis of the amino acid sequence conservation suggests that the gamma subunit family can be divided into three distinct subclasses. The division of the gamma subunit family in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78af600d237714ff68d101e9796fc571
https://doi.org/10.1006/excr.2000.4893
https://doi.org/10.1006/excr.2000.4893
Autor:
Charles Kunsch, Russell M. Medford
Publikováno v:
Circulation Research. 85:753-766
Abstract —Oxidative stress and the production of intracellular reactive oxygen species (ROS) have been implicated in the pathogenesis of a variety of diseases. In excess, ROS and their byproducts that are capable of causing oxidative damage may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86961e2acb7b21bd46405cb9cb83af7d
https://doi.org/10.1161/01.res.85.8.753
https://doi.org/10.1161/01.res.85.8.753
Autor:
Jeffrey D. Carter, Raghavendra G. Mirmira, Runpei Wu, Jerry L. Nadler, Banumathi K. Cole, Anthony P. Trace, Charles Kunsch, William S. Crim, Craig S. Nunemaker
Publikováno v:
Molecular and cellular endocrinology. 323(2)
The antioxidant and anti-inflammatory compound AGI-1067 (succinobucol) has potential as an oral anti-diabetic agent. AGI-1067 reduces H b A1c, improves fasting plasma glucose, and reduces new-onset diabetes. We investigated AGI-1067 for possible effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53bade699a18768d51ceb30df56f9948
https://pubmed.ncbi.nlm.nih.gov/20211684
https://pubmed.ncbi.nlm.nih.gov/20211684
Publikováno v:
Journal of thrombosis and thrombolysis. 27(4)
Background Oxidative stress play an important role triggering platelet/endothelial activation. AGI-1067 is a novel, phenolic antioxidant, and vascular protectant which dose-dependently inhibits PEA biomarkers in vitro. Whether treatment with AGI-1067
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4e9681e1629cc6ee7eab0cda0c85dc
https://pubmed.ncbi.nlm.nih.gov/18521540
https://pubmed.ncbi.nlm.nih.gov/18521540
Autor:
Charles Kunsch, Xi-Lin Chen
Publikováno v:
Developments in Cardiovascular Medicine ISBN: 0387295526
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dce64603c0dd12c54cfc54a9f82180f5
https://doi.org/10.1007/0-387-29553-4_5
https://doi.org/10.1007/0-387-29553-4_5
Autor:
Xi-Lin Chen, Charles Kunsch
Publikováno v:
Current pharmaceutical design. 10(8)
In the last decade, it has become recognized that reactive oxygen species (ROS) play important roles in the multiple biological processes involved in the pathophysiology of chronic inflammation such as cell proliferation, adhesion molecule expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0cb9757c3c35825ded2ac33095d98c
https://pubmed.ncbi.nlm.nih.gov/15032691
https://pubmed.ncbi.nlm.nih.gov/15032691
Autor:
Xi-Lin, Chen, Signe E, Varner, Anjali S, Rao, Janice Y, Grey, Suzanne, Thomas, Christopher K, Cook, Martin A, Wasserman, Russell M, Medford, Anil K, Jaiswal, Charles, Kunsch
Publikováno v:
The Journal of biological chemistry. 278(2)
Atherosclerotic lesions preferentially develop in areas of the vasculature exposed to nonlaminar blood flow and low fluid shear stress, whereas laminar flow and high fluid shear stress are athero-protective. We have identified a set of genes includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2a287697d3ff53dc82172c9d560615f
https://pubmed.ncbi.nlm.nih.gov/12370194
https://pubmed.ncbi.nlm.nih.gov/12370194
Autor:
Charles Q. Meng, Carolyn L. Rachita, Charles Kunsch, Cynthia L. Sundell, Jacob E. Simpson, X.Sharon Zheng, Uday Saxena, Russell R. Hill, Lynda K. Olliff, Patricia K. Somers, Sampath Parthasarathy, Martin A. Wasserman, Lisa A. Holt, Lee K. Hoong, James A. Sikorski
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(18)
A series of novel phenolic compounds has been discovered as potent inhibitors of TNF-alpha-inducible expression of vascular cell adhesion molecule-1 (VCAM-1) with concurrent antioxidant and lipid-modulating properties. Optimization of these multifunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07771add2732ec3bec96bf41c17d71fc
https://pubmed.ncbi.nlm.nih.gov/12182856
https://pubmed.ncbi.nlm.nih.gov/12182856