Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Charles Kresge"'
Autor:
Al Karim Khimji, Youxue Wang, Amal K. Dutta, Charles Kresge, Andrew Feranchak, Kristy Boggs, Yonas Getachew, Don C. Rockey
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
TMEM16A is a Ca2+-activated Cl−channel in the apical membrane of biliary epithelial cells, known as cholangiocytes, which contributes importantly to ductular bile formation. Whereas cholangiocyte TMEM16A activity is regulated by extracellular ATP-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5e781437b14f9c5a4f052cddbef53b
https://doi.org/10.1152/ajpgi.00219.2019
https://doi.org/10.1152/ajpgi.00219.2019
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Mechanosensitive signaling has emerged as a mechanism for the regulation of cholangiocyte transport and bile formation. The mechanical effect of fluid-flow, or shear, at the apical membrane of cholangiocytes regulates secretion through a process invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710ca1ffa042326dcd43aca51d35599f
https://doi.org/10.1152/ajpgi.00176.2019
https://doi.org/10.1152/ajpgi.00176.2019
Publikováno v:
Hepatology (Baltimore, Md.)
Bile acids stimulate a bicarbonate-rich choleresis, in part, through effects on cholangiocytes. Because Cl- channels in the apical membrane of cholangiocytes provide the driving force for secretion and transmembrane member 16A (TMEM16A) has been iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4fe54c1c04e3cf853d60f117bf65d0
https://pubmed.ncbi.nlm.nih.gov/29360145
https://pubmed.ncbi.nlm.nih.gov/29360145
Autor:
Andrew P. Feranchak, Katherine Luby-Phelps, Charles Kresge, Meghana Sathe, Abhijit Bugde, Matthew A. Lewis, Kangmee Woo
Publikováno v:
Journal of Biological Chemistry. 286:25363-25376
ATP in bile is a potent secretogogue, stimulating biliary epithelial cell (BEC) secretion through binding apical purinergic receptors. In response to mechanosensitive stimuli, BECs release ATP into bile, although the cellular basis of ATP release is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501914e221231443162cd8c37a33611a
https://doi.org/10.1074/jbc.m111.232868
https://doi.org/10.1074/jbc.m111.232868
Autor:
Kangmee Woo, Andrew P. Feranchak, Victoria Esser, Yoshiyuki Ueno, Julie Venter, Gianfranco Alpini, Charles Kresge, Shannon Glaser, Meghana Sathe
Publikováno v:
Hepatology. 52:1819-1828
Adenosine triphosphate (ATP) is released from cholangiocytes into bile and is a potent secretogogue by increasing intracellular Ca2+ and stimulating fluid and electrolyte secretion via binding purinergic (P2) receptors on the apical membrane. Althoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00b10c7962104c79825f8e7a618eb2c1
https://doi.org/10.1002/hep.23883
https://doi.org/10.1002/hep.23883
Autor:
Katherine Luby-Phelps, Charles Kresge, Meghana Sathe, Matthew A. Lewis, Andrew P. Feranchak, Abhijit Bugde, Peter P. Antich, J. Gregory Fitz
Publikováno v:
Journal of Biological Chemistry. 285:8138-8147
Extracellular ATP represents an important autocrine/paracrine signaling molecule within the liver. The mechanisms responsible for ATP release are unknown, and alternative pathways have been proposed, including either conductive ATP movement through c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646fcc972ed85e17a3641bc20702a1db
https://doi.org/10.1074/jbc.m109.065482
https://doi.org/10.1074/jbc.m109.065482
Publikováno v:
The Journal of Physiology. 586:2779-2798
ATP in bile is a potent secretogogue, stimulating cholangiocyte Cl− and fluid secretion via binding to membrane P2 receptors, though the physiological stimuli involved in biliary ATP release are unknown. The goal of the present studies was to deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95210d919ddb7cb0d1db9f0ea297885b
https://doi.org/10.1113/jphysiol.2008.153015
https://doi.org/10.1113/jphysiol.2008.153015
Publikováno v:
Hepatology (Baltimore, Md.). 63(2)
UNLABELLED Intrahepatic biliary epithelial cells (BECs), also known as cholangiocytes, modulate the volume and composition of bile through the regulation of secretion and absorption. While mechanosensitive Cl(-) efflux has been identified as an impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a8c2a16d720253a5173a66deba2055
https://pubmed.ncbi.nlm.nih.gov/26475057
https://pubmed.ncbi.nlm.nih.gov/26475057
Bile formation by the liver is initiated by canalicular transport at the hepatocyte membrane, leading to an increase in ductular bile flow. Thus, bile duct epithelial cells (cholangiocytes), which contribute to the volume and dilution of bile through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6d6ef6f6d4c828c285eaef2169f9b8
https://europepmc.org/articles/PMC3543635/
https://europepmc.org/articles/PMC3543635/
Publikováno v:
Biology of Reproduction. 51:509-523
An intriguing component of the maternal response to pregnancy is the differentiation of large numbers of large granular lymphocytes, termed granulated metrial gland (GMG) cells, in the decidua and then in the metrial gland, a structure in the mesomet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::322833e3227562d4a049401a9e0f0ab8
https://doi.org/10.1095/biolreprod51.3.509
https://doi.org/10.1095/biolreprod51.3.509