Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Charles Kasiewski"'
Autor:
Karen Brown, W. Ewing, Ross G. Bentley, Mark H. Perrone, Christopher L. Heran, Robert J. Leadley, Jeffrey S. Bostwick, Charles Kasiewski, Suzanne R Morgan, Spada Alfred P, Dunwiddie Christopher T, Valeria Chu, Phillip Moxey, Pauls Henry W
Publikováno v:
Journal of Cardiovascular Pharmacology. 34:791-799
These studies were designed to examine the pharmacodynamic profile and antithrombotic efficacy of RPR120844, a competitive inhibitor of coagulation factor Xa, with a K(i) of 7 nM against human factor Xa. In vitro, RPR120844 doubled activated partial
Autor:
Alfred P. Spada, Robert J. Leadley, Jonathan S. Mason, Dennis J. Colussi, Ewing William R, Mark H. Perrone, Karen D. Brown, Michael R. Becker, Don D. Cha, Daniel M. Green, Ross Bentley, Henry W. Pauls, Christopher T. Dunwiddie, Jean-Pierre Guilloteau, Y.M. Choi-Sledeski, Sebastien Maignan, Mason Helen J, Vincent E. Manetta, Charles Kasiewski, Valeria Chu, Roderick S. Davis, Suzanne Morgan, Daniel L. Cheney, Jeff Bostwick
Publikováno v:
Journal of Medicinal Chemistry. 42:3557-3571
The discovery of a series of non-peptide factor Xa (FXa) inhibitors incorporating 3-(S)-amino-2-pyrrolidinone as a central template is described. After identifying compound 4, improvements in in vitro potency involved modifications of the liphophilic
Autor:
Robert J. Leadley, Charles Kasiewski, Tara Wentz, Glenda E. Bilder, Jeffery Bostwick, Mark H. Perrone, Saul J. Needle, Betsey O’Conner, Christopher T. Dunwiddie, Lisa Byan, Kenneth Page, Helen Galczenski, Linda Merkel, Persons Paul E, Myers Michael R, Alfred P. Spada, Amin Dilip, Cuong Ly
Publikováno v:
Circulation. 99:3292-3299
Background —Platelet-derived growth factor (PDGF), a purported mediator of arterial response to injury, stimulates proliferation, chemotaxis, and matrix production by activation of its membrane receptor tyrosine kinase. Because these activities und
Autor:
Robert J. Leadley, Mark H. Perrone, Charles Kasiewski, Jeffrey S. Bostwick, Christopher T. Dunwiddie, Ross Bentley
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 18:908-914
Abstract —Experiments were designed to compare the antithrombotic efficacy of enoxaparin and unfractionated heparin (UH) in a model of platelet-dependent cyclic flow reductions (CFRs) in the stenosed canine circumflex coronary artery. Low-molecular
Autor:
Robert J. Leadley, Matthew J. McVey, Mark H. Perrone, Ross Bentley, Christopher T. Dunwiddie, Jeffrey S. Bostwick, Charles Kasiewski, Francis J White
Publikováno v:
Thrombosis and Haemostasis. 78:1278-1285
SummaryA canine model of electrolytic injury-induced coronary artery thrombosis and rtPA-induced thrombolysis was used to evaluate the relative antithrombotic efficacy of enoxaparin (a low molecular weight heparin), conventional therapy (heparin or h
Autor:
Rose D'Alisa, Bruce F. Molino, Scott I. Klein, Jeffrey M Dener, Robert J. Leadley, Charles Kasiewski, Christopher T. Dunwiddie, Charles J. Gardner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2225-2230
A series of analogs were prepared based on the known thrombin inhibitor PPACK, in which the D-Phe-Pro dipeptide has been replaced by trans-4-O-benzyl hydroxyproline. One of these analogs is a more potent inhibitor of thrombin, and is more selective,
Publikováno v:
Drug Development Research. 29:158-166
Tyrphostins (TKI) are synthetic low molecular weight compounds which inhibit in vitro platelet-derived growth factor (PDGF) mitogenesis by blocking PDGF receptor protein tyrosine kinase activity (PDGF R-PTK). To determine whether TKIs act by this mec
Autor:
Rose D'Alisa, Scott I. Klein, Jeffrey M Dener, Bruce F. Molino, Charles Kasiewski, Charles J. Gardner, Robert J. Leadley, Christopher T. Dunwiddie
Publikováno v:
ChemInform. 28
A series of analogs were prepared based on the known thrombin inhibitor PPACK, in which the D-Phe-Pro dipeptide has been replaced by trans-4-O-benzyl hydroxyproline. One of these analogs is a more potent inhibitor of thrombin, and is more selective,
Autor:
Mark H. Perrone, Robert S. Swillo, Henry F. Campbell, Richard F. Woltmann, William C. Faith, John A. Barrett, Charles Kasiewski
Publikováno v:
Journal of Cardiovascular Pharmacology. 16:537-545
The cardiovascular effects of RG W-2938, 6-[6-(3,4-dihydro-3-methyl-2(1H)-2-oxoquinazolinyl)]-4,5-dihydro-3 (2H-pyridazinone, a new nonglycoside, noncatecholamine cardiotonic/vasodilator agent were examined in vivo in anesthetized and conscious dogs
Autor:
Wei Wang, Valeria Chu, Mark H. Perrone, Ross G. Bentley, Charles Kasiewski, Robert J. Leadley, Karen Brown, Suzanne R Morgan, Dennis Colussi, Sam S. Rebello
Publikováno v:
Journal of cardiovascular pharmacology. 38(2)
Factor Xa (fXa) plays a pivotal role in the activation of the coagulation system during thrombosis, but, unlike GPIIb/IIIa receptor antagonists, the role of fXa inhibition in arterial passivation is not well defined. We compared the long-term antithr