Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Charles K. Singleton"'
Autor:
Charles K Singleton, Yanhua Xiong
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75618 (2013)
Histidine kinases are receptors for sensing cellular and environmental signals, and in response to the appropriate cue they initiate phosphorelays that regulate the activity of response regulators. The Dictyostelium discoideum genome encodes 15 histi
Externí odkaz:
https://doaj.org/article/44f71452bba54880a1b4624f9ed25f78
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32500 (2012)
A major mechanism of translational regulation in response to a variety of stresses is mediated by phosphorylation of eIF2α to reduce delivery of initiator tRNAs to scanning ribosomes. For some mRNAs, often encoding a bZIP transcription factor, eIF2
Externí odkaz:
https://doaj.org/article/2e2e02338ee846318efca2f9b5d7e00d
Publikováno v:
Eukaryotic Cell. 10:494-501
Growing Dictyostelium cells secrete CfaD and AprA, two proteins that have been characterized as chalones. They exist within a high-molecular-weight complex that reversibly inhibits cell proliferation, but not growth, via cell surface receptors and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d3abfd4f7348e594d356a6dcd6e3320
https://doi.org/10.1128/ec.00270-10
https://doi.org/10.1128/ec.00270-10
Publikováno v:
Differentiation. 74:583-595
IfkA and ifkB are two GCN2-like genes present in Dictyostelium. Disruption of either gene alone results in subtle developmental defects. However, disruption of ifkA and ifkB within the same strain results in severe morphological and patterning defect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67fd84316ce69b90b8d89c0f9c27463
https://doi.org/10.1111/j.1432-0436.2006.00085.x
https://doi.org/10.1111/j.1432-0436.2006.00085.x
Autor:
Peter R. Martin, Charles K. Singleton
Publikováno v:
Current Molecular Medicine. 1:197-207
Thiamine is required for all tissues and is found in high concentrations in skeletal muscle, heart, liver, kidneys and brain. A state of severe depletion is seen in patients on a strict thiamine-deficient diet in 18 days, but the most common cause of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe0fe295f755b1c562c7d65f6b0e222
https://doi.org/10.2174/1566524013363870
https://doi.org/10.2174/1566524013363870
Publikováno v:
CNS Spectrums. 4:66-68,81
Alcoholism can result in a number of severe consequences to the central nervous system, including Korsakoff's psychosis, delusions, delirium, Wernicke's encephalopathy, and cerebellar degeneration. Many of these disorders have a substantially higher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cf69d54c20e77dcac249e73141f04c6
https://doi.org/10.1017/s1092852900011226
https://doi.org/10.1017/s1092852900011226
Autor:
Michael J. Zinda, Charles K. Singleton
Publikováno v:
Developmental Biology. 196(2):171-183
Spore germination is a defined developmental process that marks a critical point in the life cycle of Dictyostelium discoideum. Upon germination the environmental conditions must be conducive to cell growth to ensure survival of emerged amoebae. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067bbc281e3e3772f6a04256be9d1ae7
Publikováno v:
The Journal of Nutritional Biochemistry. 9:215-222
To address tissue-specific variation in sensitivity to thiamine deficiency, three human cell types were grown in medium with various thiamine concentrations. The activity of a cytosolic and a mitochondrial thiamine diphosphate-dependent enzyme was ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7990e93672b4ebb434c3855bc91c220f
https://doi.org/10.1016/s0955-2863(97)00187-3
https://doi.org/10.1016/s0955-2863(97)00187-3
Autor:
Charles K. Singleton
Publikováno v:
Gene. 199:111-121
A positive selection scheme is described that selects for thiamine transporter clones. The scheme is based on the rescue of lethality, under non-permissive conditions, of Saccharomyces cerevisiae strains that are conditional for thiamine biosynthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb24b863c9feb7294d0a002d7c4e0cc
https://doi.org/10.1016/s0378-1119(97)00354-5
https://doi.org/10.1016/s0378-1119(97)00354-5
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1341:165-172
Active human transketolase is a homodimeric enzyme possessing two active sites, each with a non-covalently bound thiamine diphosphate and magnesium. Both subunits contribute residues at each site which are involved in cofactor binding and in catalysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeff61db196946e1e5aea4bbe0b194e3
https://doi.org/10.1016/s0167-4838(97)00067-8
https://doi.org/10.1016/s0167-4838(97)00067-8