Výsledky vyhledávání - "Charles K Kaufman"

Akademický článek

Transcriptional profile and chromatin accessibility in zebrafish melanocytes and melanoma tumors

Autor: Eva T Kramer, Paula M Godoy, Charles K Kaufman

Publikováno v: G3: Genes, Genomes, Genetics, Vol 12, Iss 1 (2021)

AbstractTranscriptional and epigenetic characterization of melanocytes and melanoma cells isolated from their in vivoDanio rerioBRAFV600EBRAFV600Ep53vs.vs.in vivo

Externí odkaz: https://doaj.org/article/b034116e264146f3b93239f3f1617193

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Akademický článek

SATB2 induction of a neural crest mesenchyme-like program drives melanoma invasion and drug resistance

Autor: Maurizio Fazio, Ellen van Rooijen, Michelle Dang, Glenn van de Hoek, Julien Ablain, Jeffrey K Mito, Song Yang, Andrew Thomas, Jonathan Michael, Tania Fabo, Rodsy Modhurima, Patrizia Pessina, Charles K Kaufman, Yi Zhou, Richard M White, Leonard I Zon

Publikováno v: eLife, Vol 10 (2021)

Recent genomic and scRNA-seq analyses of melanoma demonstrated a lack of recurrent genetic drivers of metastasis, while identifying common transcriptional states correlating with invasion or drug resistance. To test whether transcriptional adaptation

Externí odkaz: https://doaj.org/article/b2a52bd0b3874cc18579f387a8732b1a

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Akademický článek

A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development

Autor: Christie Ciarlo, Charles K Kaufman, Beste Kinikoglu, Jonathan Michael, Song Yang, Christopher D′Amato, Sasja Blokzijl-Franke, Jeroen den Hertog, Thorsten M Schlaeger, Yi Zhou, Eric Liao, Leonard I Zon

Publikováno v: eLife, Vol 6 (2017)

The neural crest is a dynamic progenitor cell population that arises at the border of neural and non-neural ectoderm. The inductive roles of FGF, Wnt, and BMP at the neural plate border are well established, but the signals required for subsequent ne

Externí odkaz: https://doaj.org/article/4e867ca3e3604b41ae20053ecbe3739f

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Akademický článek

Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes

Autor: Dorit Hockman, Alan J Burns, Gerhard Schlosser, Keith P Gates, Benjamin Jevans, Alessandro Mongera, Shannon Fisher, Gokhan Unlu, Ela W Knapik, Charles K Kaufman, Christian Mosimann, Leonard I Zon, Joseph J Lancman, P Duc S Dong, Heiko Lickert, Abigail S Tucker, Clare V H Baker

Publikováno v: eLife, Vol 6 (2017)

The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes – carotid body glomus cells, and ‘pulmonary neuroendocrine cells’ (PNECs) - are obscure. Homology has been proposed between glomus cells, which ar

Externí odkaz: https://doaj.org/article/90ee98c22520473bb323c934cc72f10b

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Akademický článek

Functional analysis of recurrent CDC20 promoter variants in human melanoma

Autor: Paula M. Godoy, Abimbola Oyedeji, Jacqueline L. Mudd, Vasilios A. Morikis, Anna P. Zarov, Gregory D. Longmore, Ryan C. Fields, Charles K. Kaufman

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)

Abstract Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can activate oncogenic gene regulatory networks. Melanoma is heavily burdened by non-coding varia

Externí odkaz: https://doaj.org/article/74b900f059654a8b8f4f21f8c7bb487d

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