Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Charles K, Perry"'
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Evaluation of Synthetic Cytochrome P450-Mimetic Metalloporphyrins To Facilitate 'Biomimetic' Biotransformation of a Series of mGlu5 Allosteric Ligands
Autor: Colleen M. Niswender, Christopher C Presley, P. Jeffrey Conn, Vincent B. Luscombe, Alice L. Rodriguez, Charles K. Perry, Craig W. Lindsley, Matthew J. Mulder, Elizabeth S. Childress
Publikováno v: ACS Omega, Vol 4, Iss 7, Pp 12782-12789 (2019)
Allosteric ligands within a given chemotype can have the propensity to display a wide range of pharmacology, as well as unexpected changes in GPCR subtype selectivity, typically mediated by single-atom modifications to the ligand. Due to the unexpect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d507940bc2a7cff2b1f11bcdaff15da0
https://doi.org/10.1021/acsomega.9b02017
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4
Synthesis of novel 5-substituted-2-aminotetralin analogs: 5-HT1A and 5-HT7 G protein-coupled receptor affinity, 3D-QSAR and molecular modeling
Autor: Raymond G. Booth, Mehreen Zaka, Charles K. Perry, Daniel E. Felsing, Glen E. Kellogg, Meng Cui, Noah B. Herrington, Rajender Vemula, Clinton E. Canal, Austen B. Casey
Publikováno v: Bioorganic & Medicinal Chemistry. 28:115262
The serotonin 5-HT7 G protein-coupled receptor (GPCR) is a proposed pharmacotherapeutic target for a variety of central and peripheral indications, albeit, there are no approved drugs selective for binding 5-HT7. We previously reported that a lead an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23f14acd52f9611f26364f7fb8193bd0
https://doi.org/10.1016/j.bmc.2019.115262
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5
An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT7 and 5-HT1A Receptor Partial Agonist That Corrects Motor Stereotypy in Mouse Models
Autor: Yue Liu, Rajender Vemula, Clinton E. Canal, JodiAnne T. Wood, Wanying Zhu, Charles K. Perry, Daniel E. Felsing, Raymond G. Booth
Publikováno v: ACS Chemical Neuroscience. 6:1259-1270
Stereotypy (e.g., repetitive hand waving) is a key phenotype of autism spectrum disorder, Fragile X and Rett syndromes, and other neuropsychiatric disorders, and its severity correlates with cognitive and attention deficits. There are no effective tr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed64a9eb63f2089455e7adeeee0eb7e3
https://doi.org/10.1021/acschemneuro.5b00099
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6
Total synthesis of violaceimides A–E and consideration of the reported stereochemistry
Autor: Charles K. Perry, Mark G. Fulton, Craig W. Lindsley
Publikováno v: Tetrahedron Letters. 60:151103
Here we report the first total synthesis of violaceimides A–E, a family of sulfur-containing metabolites from Aspergillus violaceus, a sponge-associated fungus. A concise, convergent and enantioselective synthesis was developed for all five family
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::decd5d424a9587c2ffe23dc34aa1f6e6
https://doi.org/10.1016/j.tetlet.2019.151103
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7
Total synthesis of Punicagranine
Autor: Charles K. Perry, Craig W. Lindsley
Publikováno v: Tetrahedron Letters. 60:150989
This communication details the first total synthesis of Punicagranine, a new pyrrolizine alkaloid isolated from the peels of the pomengranate, Punica granatum, the basis for traditional Chinese medicine, with anti-inflammatory activity. Two concise,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92eeab48c254d865a61bef9d5dadb766
https://doi.org/10.1016/j.tetlet.2019.150989
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