Novel insights in drug transporter sciences: the year 2021 in review

Autor: Paresh P. Chothe, Pallabi Mitra, Masanori Nakakariya, Diane Ramsden, Charles J. Rotter, Philip Sandoval, Kimio Tohyama

Publikováno v: Drug Metabolism Reviews. 54:299-317

On behalf of the team I am pleased to present the second annual 'novel insights into drug transporter sciences review' focused on peer-reviewed articles that were published in the year 2021. In compiling the articles for inclusion, preprints availabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a028bb269c4a20a1ee02fa8fec23157
https://doi.org/10.1080/03602532.2022.2094944

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Autor: Richard Lloyd, Leon Aarons, Mark McAllister, Amitava Mitra, Chester Costales, Timo Korjamo, Maria Hammarberg, Helena Thörn, Carole Shardlow, Jussi Malkki, Adam S. Darwich, Tycho Heimbach, Achiel Van Peer, James M. Mullin, Jennifer B. Dressman, Johanna Laru, Dónal Murphy, Handan He, Jian Lin, Irina Mishenzon, Ke X. Szeto, Mei Wong, Peter Langguth, Bertil Abrahamsson, Carolin Hoft, Fan Wu, Mohammed Yasin, Olivier Nicolas, Manthena V.S. Varma, Alison Margolskee, Christer Tannergren, Edmund Kostewicz, Yan Pang, Shriram M. Pathak, Johanna Tuunainen, Constanze Hilgendorf, Sari Pappinen, Viera Lukacova, Charles J. Rotter, Jan Bevernage, Sweta Modi, Sergej Ramusovic, Simone Hansmann, Mai Anh Nguyen, Amin Rostami-Hodjegan, Eva Huehn, Michael B. Bolger, Jonathan Brown, Loic Laplanche, Christine Xu, Eva Karlsson, Sara Carlert, Pernilla Johansson, Florent Mazuir, Jeike Biewenga, Xavier Pepin, Hans Lennernäs, Aleksandra Galetin

Publikováno v: Margolskee, A, Darwich, A, Aarons, L, Galetin, A, Rostami-Hochaghan, A, Carlert, S, Hammarberg, M, Hilgendorf, C, Johansson, P, Karlsson, E, Murphy, D, Tannergren, C, Thorn, H, Yasin, M, Mazuir, F, Nicolas, O, Ramusovic, S, Xu, C, Pathak, S, Korjamo, T, Laru, J, Malkki, J, Pappinen, S, Tuunainen, J, Dressman, J, Hansmann, S, Kostewicz, E, He, H, Heimbach, T, Wu, F, Hoft, C, Laplanche, L, Pang, Y, Bolger, M B, Huehn, E, Lukacova, V, Mullin, J M, Szeto, K X, Costales, C, Lin, J, McAllister, M, Modi, S, Rotter, C, Varma, M, Wong, M, Mitra, A, Bevernage, J, Biewenga, J, Van Peer, A, Lloyd, R, Shardlow, C, Langguth, P, Mishenzon, I, Nguyen, M A, Brown, J, Lennernas, H & Abrahamsson, B 2016, ' IMI – Oral Biopharmaceutics Tools project – Evaluation of Bottom-up PBPK Prediction Success Part 2: An Introduction to the Simulation Exercise and Overview of Results ', European Journal of Pharmaceutical Sciences . https://doi.org/10.1016/j.ejps.2016.10.036

Orally administered drugs are subject to a number of barriers impacting bioavailability (Foral), causing challenges during drug and formulation development. Physiologically-based pharmacokinetic (PBPK) modelling can help during drug and formulation d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6089d0117fb2833be9097c7fcd93759e
https://doi.org/10.1016/j.ejps.2016.10.036

Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed

Autor: Barbara Colless, Stephanie Chaousis, Timothy A. Hill, Martin J. Stoermer, Andrew J. Lucke, Rink-Jan Lohman, Ligong Liu, Daniel S. Nielsen, Spiros Liras, Roger B. Ruggeri, Charles J. Rotter, Conor C G Scully, David J. Edmonds, Huy N. Hoang, W. Mei Kok, David Price, David P. Fairlie, Paul V. Bernhardt, David A. Griffith, Christina I. Schroeder, David J. Craik

Publikováno v: ACS Medicinal Chemistry Letters. 5:1148-1151

Development of peptide-based drugs has been severely limited by lack of oral bioavailability with less than a handful of peptides being truly orally bioavailable, mainly cyclic peptides with N-methyl amino acids and few hydrogen bond donors. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0776d1fb6036db55fc9f76aad6682322
https://doi.org/10.1021/ml5002823

Quantitative assessment of the contribution of sodium-dependent taurocholate co-transporting polypeptide (NTCP) to the hepatic uptake of rosuvastatin, pitavastatin and fluvastatin

Autor: Charles J. Rotter, Ayman F. EI-Kattan, Yurong Lai, Xi Qiu, Manthena V.S. Varma, Yi-an Bi, Mary Piotrowski, Emi Kimoto

Publikováno v: Biopharmaceutics & Drug Disposition. 34:452-461

Hepatic uptake transport is often the rate-determining step in the systemic clearance of drugs. The ability to predict uptake clearance and to determine the contribution of individual transporters to overall hepatic uptake is therefore critical in as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03722a8ef348868b39205d988ac2e375
https://doi.org/10.1002/bdd.1861

Elucidation of the biochemical basis for a clinical drug–drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778 875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha

Autor: Steven G. Terra, Mark A. West, Charles J. Rotter, Amit S. Kalgutkar, Robert L. Walsky, Bo Feng, Manthena V.S. Varma, Renato J. Scialis, Kosea S. Frederick, Omar L. Francone, James R. Gosset, Theunis C. Goosen, Danny Chen

Publikováno v: Xenobiotica. 43:963-972

1. 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778875), an agonist of the peroxisome proliferator-activated receptor alpha, has been evaluated in the clinic to treat dyslipidemia and type 2 diabetes mellitus. Herein, we i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e370b585737a88efde05476bab223865
https://doi.org/10.3109/00498254.2013.791004