Zobrazeno 1 - 10
of 431
pro vyhledávání: '"Charles J. Rosser"'
Autor:
Hideki Furuya, Toru Sakatani, Sunao Tanaka, Kaoru Murakami, Richard T. Waldron, Wayne Hogrefe, Charles J. Rosser
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-9 (2024)
Abstract Background No single marker of bladder cancer (BC) exists in urine samples with sufficient accuracy for disease diagnosis and treatment monitoring. The multiplex Oncuria BC assay noninvasively quantifies the concentration of 10 protein analy
Externí odkaz:
https://doaj.org/article/2313805b4e1f43b4a5883d57f56a6e8e
Autor:
Hideki Furuya, Yuka Sasaki, Runpu Chen, Rafael Peres, Kanani Hokutan, Kaoru Murakami, Nari Kim, Owen T. M. Chan, Ian Pagano, Lars Dyrskjøt, Jørgen B. Jensen, Per-Uno Malmstrom, Ulrika Segersten, Yijun Sun, Abolfazl Arab, Hani Goodarzi, Steve Goodison, Charles J. Rosser
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The extracellular activity of Plasminogen activator inhibitor-1 (PAI-1) is well described, acting as an inhibitor of tissue plasminogen activator and urokinase-type plasminogen activator, impacting fibrinolysis. Recent studies have revealed
Externí odkaz:
https://doaj.org/article/1552f505b3f3484bb224cce583c25fb3
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Bladder cancer is a complex disease with variable prognosis. Recent investigations into the molecular landscape of bladder cancer have revealed frequent genetic alterations and molecular subtypes with therapeutic implications. Consequently, a shift t
Externí odkaz:
https://doaj.org/article/746f7b6388b4401581657b073d1774c7
Autor:
Kenneth H. Gouin, Nathan Ing, Jasmine T. Plummer, Charles J. Rosser, Bassem Ben Cheikh, Catherine Oh, Stephanie S. Chen, Keith Syson Chan, Hideki Furuya, Warren G. Tourtellotte, Simon R. V. Knott, Dan Theodorescu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The identification of response biomarkers for surgery, chemotherapy and immune checkpoint therapy in bladder cancer is crucial. Here, single nuclei RNA sequencing and spatial profiling identify a cancer cell population expressing Neural Type Cadherin
Externí odkaz:
https://doaj.org/article/5b25f04e5b884ae4a0e99e6169061c15
Autor:
Yosuke Hirasawa, Ian Pagano, Runpu Chen, Yijun Sun, Yunfeng Dai, Amit Gupta, Sergei Tikhonenkov, Steve Goodison, Charles J. Rosser, Hideki Furuya
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-10 (2021)
Abstract Background Due to insufficient accuracy, urine-based assays currently have a limited role in the management of patients with bladder cancer. The identification of multiplex molecular signatures associated with disease has the potential to ad
Externí odkaz:
https://doaj.org/article/74fa989e3a7d4146a10ac40cfcc7000f
Autor:
Hideki Furuya, Kazukuni Hayashi, Yoshiko Shimizu, Nari Kim, Yutaro Tsukikawa, Runpu Chen, Yijun Sun, Owen T. M. Chan, Ian Pagano, Rafael Peres, Kanani Hokutan, Fumie Igari, Keith S. Chan, Charles J. Rosser
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
Abstract Background Accumulating evidence suggests that plasminogen activator inhibitor-1 (PAI-1) plays an important role in bladder tumorigenesis by regulating cell cycle. However, it remains unclear whether and how inhibition of PAI-1 suppresses bl
Externí odkaz:
https://doaj.org/article/4752b31a3be945218043704ddb5aa5c8
Autor:
Hideki Furuya, Owen T. M. Chan, Ian Pagano, Chengjun Zhu, Nari Kim, Rafael Peres, Kanani Hokutan, Sarah Alter, Peter Rhode, Charles J. Rosser
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-12 (2019)
Abstract Background We set out to determine if the administration of subcutaneous (SQ) ALT-803 was non-inferior to standard intravesical BCG treatment in a carcinogen induced mouse (C57BL/6J) bladder cancer model. Methods Using this well-established
Externí odkaz:
https://doaj.org/article/fcab66ab53f545cfaf9a1ab7e8fe66a8
Autor:
Runpu Chen, Ian Pagano, Yijun Sun, Kaoru Murakami, Steve Goodison, Ramanathan Vairavan, Malak Tahsin, Peter C. Black, Charles J. Rosser, Hideki Furuya
Publikováno v:
Diagnostics, Vol 12, Iss 8, p 1801 (2022)
Bladder cancer is a biologically heterogeneous disease with variable clinical presentations, outcomes and responses to therapy. Thus, the clinical utility of single biomarkers for the detection and prediction of biological behavior of bladder cancer
Externí odkaz:
https://doaj.org/article/dd534a562a404d6aa7e6b3f7faebb511
Autor:
Charles J. Rosser, Sergei Tikhonenkov, Jeffrey W. Nix, Owen T.M. Chan, Irina Ianculescu, Sandeep Reddy, Patrick Soon-Shiong
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Intravesical BCG is active against non-muscle invasive bladder cancer (NMIBC), but bladder cancer will recur and even progress in a significant number of patients. To improve the response rate, N-803, an IL-15 superagonist was administered in combina
Externí odkaz:
https://doaj.org/article/410f239843d44185927c1ca4eaf1585a
Autor:
Hideki Furuya, Lindlelyn Tabula, Riko Lee, Paul Kralovec, Martin Ramsden, Regan Wong, Charles J. Rosser
Publikováno v:
Practical Laboratory Medicine, Vol 22, Iss , Pp e00189- (2020)
Background: The objective of our study was to assess the analytical performance of a multiplex assay (Oncuria™) to quantify protein biomarkers towards a bladder cancer associated diagnostic signature in voided urine. Method: ology: Using Luminex xM
Externí odkaz:
https://doaj.org/article/f91a8819ce8a402d923afc5774055a4d