Zobrazeno 1 - 10
of 221
pro vyhledávání: '"Charles J. Malemud"'
Autor:
Hassan Ahmad, Mariam Khan, Michelle Laugle, Desmond A. Jackson, Christopher Burant, Charles J. Malemud, Ali D. Askari, Maya Mattar, David E. Blumenthal, David A. Zidar, Donald D. Anthony
Publikováno v:
International Journal of Rheumatology, Vol 2018 (2018)
Background. Red blood cell distribution width (RDW) is a routine hematologic parameter that is a predictor of cardiovascular disease (CVD) events and is independent of combined traditional risk factor scoring systems. The RDW has also been associated
Externí odkaz:
https://doaj.org/article/127f4347c8d246c7951c4008c4bbf21a
Autor:
Nathan Lu, Charles J. Malemud
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 15, p 3792 (2019)
Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein kinase family of signaling molecules. ERK is predominantly found in two forms, ERK1 (p44) and ERK2 (p42), respectively. There are also several atypical forms of
Externí odkaz:
https://doaj.org/article/0b3cc28f04e84f0881cf67d6968d9451
Autor:
Charles J. Malemud
Publikováno v:
Cells, Vol 7, Iss 12, p 223 (2018)
Rheumatoid arthritis (RA) is a chronic, progressive, systemic autoimmune disease that mostly affects small and large synovial joints. At the molecular level, RA is characterized by a profoundly defective innate and adaptive immune response that resul
Externí odkaz:
https://doaj.org/article/28f2fd7bd3694dc990d6f6ebf9655e98
Autor:
Charles J. Malemud
Publikováno v:
Cells, Vol 7, Iss 8, p 92 (2018)
An imbalance in gene expressional events skewing chondrocyte anabolic and catabolic pathways toward the latter causes an aberrant turnover and loss of extracellular matrix proteins in osteoarthritic (OA) articular cartilage. Thus, catabolism results
Externí odkaz:
https://doaj.org/article/2c969b845b9840c9807c807435059ee0
Autor:
Charles J. Malemud
Publikováno v:
Pharmaceuticals, Vol 3, Iss 5, Pp 1446-1455 (2010)
A skewed ratio of pro-inflammatory to anti-inflammatory cytokines, elevated growth factor synthesis and T- and B-lymphocyte activation are 3 hallmarks of rheumatoid arthritis (RA) pathology. Interleukin-6 (IL-6), IL-7, IL-17, IL-12/IL-23 and growth f
Externí odkaz:
https://doaj.org/article/670536e5cb7a43ec8dcb4ddd33b6d478
Autor:
Graham Akeson, Charles J. Malemud
Publikováno v:
Journal of Functional Morphology and Kinesiology, Vol 2, Iss 3, p 27 (2017)
Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines present at elevated levels in the synovial fluid of individuals with confirmed clinical diagnosis of rheumatoid arthritis (RA) and osteoarthritis (OA). The mechanism of action of IL-6
Externí odkaz:
https://doaj.org/article/90ff7f59abd046ba8b62675813fde963
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 5, p 1084 (2017)
Idiopathic inflammatory myopathies (IIMs) are a group of autoimmune muscle diseases with significant morbidity and mortality. This review details and updates the pathogenesis and emerging importance of myositis-specific antibodies in the development
Externí odkaz:
https://doaj.org/article/74f16fb4462d42a0937e585f974d3eac
Autor:
Charles J. Malemud
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 3, p 484 (2017)
Elevated levels of pro-inflammatory cytokines are generally thought to be responsible for driving the progression of synovial joint inflammation in rheumatoid arthritis (RA) and osteoarthritis (OA). These cytokines activate several signal transductio
Externí odkaz:
https://doaj.org/article/ce79c7ad0cc54ee1894f917aa9a94fe0
Publikováno v:
Mediators of Inflammation, Vol 2014 (2014)
Externí odkaz:
https://doaj.org/article/12b1cf9887524c178ade08003ff2004f
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 5, p 725 (2016)
The nucleotide-binding domain, leucine-rich repeat/pyrin domain-containing-3 (NALP3) inflammasome, which is required for synthesis of interleukin-1β, has been implicated in the pathogenesis of several autoinflammatory syndromes. This review of the l
Externí odkaz:
https://doaj.org/article/3f7990947a044bb5988e534effd0d1ad