Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Charles J. Lacey"'
Autor:
Kathy Baisley, MSc, Troy J Kemp, PhD, Aimée R Kreimer, PhD, Partha Basu, PhD, John Changalucha, MSc, Allan Hildesheim, PhD, Carolina Porras, MSc, Hilary Whitworth, PhD, Rolando Herrero, PhD, Charles J Lacey, MD, John T Schiller, PhD, Eric Lucas, MSc, Paul Mutani, MD, Joakim Dillner, PhD, Jackton Indangasi, MSc, Richard Muwonge, PhD, Richard J Hayes, DSc, Ligia A Pinto, PhD, Deborah Watson-Jones, PhD
Publikováno v:
The Lancet Global Health, Vol 10, Iss 10, Pp e1485-e1493 (2022)
Summary: Background: Human papillomavirus (HPV) vaccines are given as a two-dose schedule in children aged 9–14 years, or as three doses in older individuals. We compared antibody responses after one dose of HPV vaccine in the Dose Reduction Immuno
Externí odkaz:
https://doaj.org/article/bf9f94967e13494a8f7463ddd3a33ca7
Autor:
Deborah Watson-Jones, ProfPhD, John Changalucha, MSc, Hilary Whitworth, PhD, Ligia Pinto, PhD, Paul Mutani, MD, Jackton Indangasi, MSc, Troy Kemp, PhD, Ramadhan Hashim, BSc, Beatrice Kamala, Dip, Rebecca Wiggins, PhD, Twaib Songoro, BA, Nicholas Connor, MSc, Gladys Mbwanji, MSc, Miquel A Pavon, PhD, Brett Lowe, MSc, Devis Mmbando, BSc, Saidi Kapiga, ProfPhD, Philippe Mayaud, ProfMD, Silvia de SanJosé, MD, Joakim Dillner, ProfPhD, Richard J Hayes, ProfDSc, Charles J Lacey, ProfMD, Kathy Baisley, MSc
Publikováno v:
The Lancet Global Health, Vol 10, Iss 10, Pp e1473-e1484 (2022)
Summary: Background: An estimated 15% of girls aged 9–14 years worldwide have been vaccinated against human papillomavirus (HPV) with the recommended two-dose or three-dose schedules. A one-dose HPV vaccine schedule would be simpler and cheaper to
Externí odkaz:
https://doaj.org/article/b52f22f640384d13ab341ba7a8d80f06
Autor:
Vivak Parkash, Georgina Jones, Nina Martin, Morgan Steigmann, Elizabeth Greensted, Paul Kaye, Alison M. Layton, Charles J. Lacey
Publikováno v:
Research Involvement and Engagement, Vol 7, Iss 1, Pp 1-12 (2021)
Plain English summary Our research team is designing a type of research study known as a controlled human infection model (CHIM). In CHIM studies, volunteers are exposed to infections on purpose and then studied to help understand diseases. Similar e
Externí odkaz:
https://doaj.org/article/c08584d30cc84f3ab8e4c7e6c194c60d
Autor:
Helen Ashwin, Jovana Sadlova, Barbora Vojtkova, Tomas Becvar, Patrick Lypaczewski, Eli Schwartz, Elizabeth Greensted, Katrien Van Bocxlaer, Marion Pasin, Kai S. Lipinski, Vivak Parkash, Greg Matlashewski, Alison M. Layton, Charles J. Lacey, Charles L. Jaffe, Petr Volf, Paul M. Kaye
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Controlled human infection models (CHIMs) provide a pathway for accelerating vaccine development. Here, the authors describe the isolation, characterization, and GMP manufacture of a clinical Leishmania major strain to be used as a resource for CHIM
Externí odkaz:
https://doaj.org/article/ddd377d986694040985714870d5c4e1c
Autor:
Jason Cosgrove, Mario Novkovic, Stefan Albrecht, Natalia B. Pikor, Zhaoukun Zhou, Lucas Onder, Urs Mörbe, Jovana Cupovic, Helen Miller, Kieran Alden, Anne Thuery, Peter O’Toole, Rita Pinter, Simon Jarrett, Emily Taylor, Daniel Venetz, Manfred Heller, Mariagrazia Uguccioni, Daniel F. Legler, Charles J. Lacey, Andrew Coatesworth, Wojciech G. Polak, Tom Cupedo, Bénedicte Manoury, Marcus Thelen, Jens V. Stein, Marlene Wolf, Mark C. Leake, Jon Timmis, Burkhard Ludewig, Mark C. Coles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes
Externí odkaz:
https://doaj.org/article/a29fe9ea7a8d465093c19a3301a148f3
Publikováno v:
Open Journal of Bioresources, Vol 5 (2018)
The York Tissue Bank was established in 2013 at the University of York as a repository for cells and tissues to facilitate clinical and translational research at the university and with collaborative external tissue bank applicants. The bioresource d
Externí odkaz:
https://doaj.org/article/1f62b42e6750431dbbc5909148b098c6
Autor:
Mohamed Osman, Anoop Mistry, Ada Keding, Rhian Gabe, Elizabeth Cook, Sarah Forrester, Rebecca Wiggins, Stefania Di Marco, Stefano Colloca, Loredana Siani, Riccardo Cortese, Deborah F Smith, Toni Aebischer, Paul M Kaye, Charles J Lacey
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005527 (2017)
Visceral leishmaniasis (VL or kala azar) is the most serious form of human leishmaniasis, responsible for over 20,000 deaths annually, and post kala azar dermal leishmaniasis (PKDL) is a stigmatizing skin condition that often occurs in patients after
Externí odkaz:
https://doaj.org/article/afc949330e6d47519f3b964e69958d97
Autor:
Catherine A Cosgrove, Charles J Lacey, Alethea V Cope, Angela Bartolf, Georgina Morris, Celine Yan, Susan Baden, Tom Cole, Darrick Carter, Elizabeth Brodnicki, Xiaoying Shen, Sarah Joseph, Stephen C DeRosa, Lili Peng, Xuesong Yu, Guido Ferrari, Mike Seaman, David C Montefiori, Nicole Frahm, Georgia D Tomaras, Wolfgang Stöhr, Sheena McCormack, Robin J Shattock
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0152038 (2016)
BackgroundDefining optimal routes for induction of mucosal immunity represents an important research priority for the HIV-1 vaccine field. In particular, it remains unclear whether mucosal routes of immunization can improve mucosal immune responses.M
Externí odkaz:
https://doaj.org/article/08ec5605bc8444f7b1cb6ed38f6f0216
Autor:
Georgina C Morris, Rebecca C Wiggins, Sarah C Woodhall, J Martin Bland, Carol R Taylor, Vicky Jespers, Brigitta A Vcelar, Charles J Lacey
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e116153 (2014)
BACKGROUND:Monoclonal antibodies (mAbs) which potently neutralize a broad range of HIV isolates are potential microbicide candidates. To date, topical application of mAbs in humans and their stability in vaginal secretions has not been studied. OBJEC
Externí odkaz:
https://doaj.org/article/a3b0fc2ba9624b29ad2ded986ead3de1
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114824 (2014)
The prevalence of sexually transmitted infections (STIs) is often higher in females than in males. Although the reproductive cycle profoundly modulates local immunity in the female reproductive tract (FRT) system, significant gaps in our knowledge of
Externí odkaz:
https://doaj.org/article/4c1b1b49b676412b87fa297bd44b5208