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pro vyhledávání: '"Charles J. Brokaw"'
Autor:
Charles J. Brokaw
Publikováno v:
Biophysical Journal. 97(11):2939-2947
A regular cycle of dynein-driven sliding, doublet separation, doublet reassociation, and resumption of sliding was previously observed by Aoyama and Kamiya in outer doublet pairs obtained after partial dissociation of Chlamydomonas flagella. In the w
Autor:
Charles J. Brokaw
Experimental observations on cyclic splitting and bending by a flagellar doublet pair are modeled using forces obtained from a model for dynein mechanochemistry, based on ideas introduced by Andrew Huxley and Terrill Hill and extended previously for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b9f4467549fcf7aa3797c1147169ca
https://resolver.caltech.edu/CaltechAUTHORS:20140310-091040155
https://resolver.caltech.edu/CaltechAUTHORS:20140310-091040155
Autor:
Charles J. Brokaw
Publikováno v:
Biophysical Journal. 81(3):1333-1344
Interaction between a protein and a series of binding sites on a cytoskeletal substrate can create a resistance, or “protein friction,” as the protein is moved along the substrate. If attachment and detachment rates are specified asymmetrically,
Autor:
Charles J. Brokaw
Publikováno v:
Mathematical Methods in the Applied Sciences. 24:1351-1365
Autor:
Charles J. Brokaw
Publikováno v:
Cell Motility and the Cytoskeleton. 47:108-119
Computer simulations have been used in an attempt to understand experimental observations of processive and oscillatory sliding by one or a few axonemal dyneins. A simple two-headed model has been examined using stochastic simulation methods. To expl
Autor:
Charles J. Brokaw
Publikováno v:
Cell Motility and the Cytoskeleton. 42:134-148
Outer arm dynein removal from flagella by genetic or chemical methods causes decreased frequency and power, but little change in bending pattern. These results suggest that outer arm dynein operates within bends to increase the speed of bend propagat
Autor:
Charles J. Brokaw
Publikováno v:
Cell Motility and the Cytoskeleton. 42:125-133
Two procedures were used for extraction of demembranated sea urchin sperm flagella with increased KCl concentrations, to remove outer dynein arms. Extraction with 0.55 M KCl in the Triton-demembranation solution produced a rapid fall in average slidi
Autor:
Landon L. Moore, Trevor Sherwin, Keith Gull, Jonathan H. LeBowitz, Philippe Bastin, Cecilia Santrich, Charles J. Brokaw
Publikováno v:
Molecular and Biochemical Parasitology. 90:95-109
We demonstrate a functional role for the paraflagellar rod (PFR) in motility of Leishmania mexicana. The PFR is a complex cytoskeletal structure running parallel to the axoneme in the flagella of kinetoplastid protozoa. The PFR is composed of a latti
Publikováno v:
Cell Motility and the Cytoskeleton. 38:91-99
Paralyzed flagella (pf) mutants of Chlamydomonas have been distinguished by the inability of the intact cells to move. Demembranated flagella from these mutants are also immotile when reactivated under standard conditions, with millimolar ATP concent
Autor:
Charles J. Brokaw
Publikováno v:
Cell Motility and the Cytoskeleton. 37:346-362
Demembranated sperm flagella of Ciona were reactivated at increased salt concentrations (0.45 to 0.5 M K acetate). In addition to a decrease in amplitude of propagated bends, some flagella switch between "stable" and "transient" bending cycles. In th