Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Charles J Waechter"'
Autor:
Michael Wetter, David Goulding, Derek Pickard, Michael Kowarik, Charles J Waechter, Gordon Dougan, Michael Wacker
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45609 (2012)
The Vi capsular polysaccharide (CPS) of Salmonella enterica serovar Typhi, the cause of human typhoid, is important for infectivity and virulence. The Vi biosynthetic machinery is encoded within the viaB locus composed of 10 genes involved in regulat
Externí odkaz:
https://doaj.org/article/bb34846adc6d4a08abf8ede39f4837bc
Autor:
Harrison A. Clarke, Craig W. Vander Kooi, Dustin D. Armstrong, Anna A. DePaoli-Roach, Richard R. Drake, Kia H. Markussen, Richard E. Taylor, Jessica K. A. Macedo, Lyndsay E.A. Young, Lindsey R. Conroy, Charles J. Waechter, Matthew S. Gentry, Ronald C. Bruntz, Ramon C. Sun, Christine Fillmore Brainson, Alexandra E. Stanback, Buyun Tang, William C. Sanders, Shane Emanuelle, Dyann M. Segvich, Elizabeth J. Allenger, M. Kathryn Brewer, Peter J. Roach, Krishna K. Mahalingan, Robert Shaffer, Annette Mestas, Vimbai M. Chikwana, Zhengqiu Zhou, Thomas D. Hurley, Tara R. Hawkinson, Alberto Rondon, Christopher J. Contreras, Lance A. Johnson
Publikováno v:
Cell Metab
Summary Glycosylation defects are a hallmark of many nervous system diseases. However, the molecular and metabolic basis for this pathology is not fully understood. In this study, we found that N-linked protein glycosylation in the brain is metabolic
Autor:
Luc Régal, Katie Clarkson, Katherine Lachlan, Kati J. Buckingham, Charles J. Waechter, F. Sessions Cole, Kimiyo Raymond, Rita Barone, Daisy Rymen, Derek Wong, Arve Vøllo, Gert Matthijs, Jay Shendure, Alina T. Midro, Erik A. Eklund, Hudson H. Freeze, Rudy Van Coster, Gregory M. Cooper, Jeffrey S. Rush, Sergey A. Shiryaev, Luísa Diogo, Philip James, Andrew J. Kornberg, Laurie A. Demmer, Jose E. Abdenur, Valerie Race, Maria Kibaek, Shawn O'Connor, Lynne A. Wolfe, Amarilis Sanchez-Valle, Agata Fiumara, Miao He, Raymond Y. Wang, Alex J. Fay, Martin Kircher, Rebecca D. Ganetzky, William A. Gahl, Erika Souche, Füsun Alehan, Amy Yang, Michael J. Bamshad, Himanshu Goel, S. Lane Rutledge, Jane E. Brumbaugh, Susan Sparks, Daniel Katz, Can Ficicioglu, Bobby G. Ng, Jaak Jaeken, Heidi Peters, Christina Lam, Gerard T. Berry, Liesbeth Keldermans, Eric Vilain, Tim Wood, Lyndsay A. Harshman, Deborah A. Nickerson, Pamela Trapane, Joy Yaplito-Lee
Publikováno v:
Human Mutation. 37:653-660
Congenital disorders of glycosylation (CDG) arise from pathogenic mutations in over one hundred genes leading to impaired protein or lipid glycosylation. ALG1 encodes a β1,4 mannosyltransferase that catalyzes the addition of the first of nine mannos
Autor:
Fredrick O. Onono, Charles J. Waechter, Thangaiah Subramanian, Jeffrey S. Rush, Karunai Leela Subramanian, Hans Peter Spielmann
Publikováno v:
Current Chemical Biology. 9:123-141
Dolichyl phosphate-linked mono- and oligosaccharides (DLO) are essential intermediates in protein N-glycosylation, C- and O-mannosylation and GPI anchor biosynthesis. While many membrane proteins in the endoplasmic reticulum (ER) involved in the asse
The precursor oligosaccharide donor for protein N-glycosylation in eukaryotes, Glc3Man9GlcNAc(2)-P-P-dolichol, is synthesized in two stages on both leaflets of the rough endoplasmic reticulum (ER). There is good evidence that the level of dolichyl mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1753eed7c7e04d0d2dd91b2012d94f2a
http://doc.rero.ch/record/302169/files/cwe064.pdf
http://doc.rero.ch/record/302169/files/cwe064.pdf
Autor:
Lakshmi Mehta, Kevin P. Campbell, Charles J. Waechter, Tobias Willer, Amy Yang, Bobby G. Ng, Jeffrey S. Rush, Kimiyo Raymond, Hudson H. Freeze, Steven A. Moore
Publikováno v:
Molecular Genetics and Metabolism. 110:345-351
Congenital disorders of glycosylation (CDG) are rare genetic defects mainly in the post-translational modification of proteins via attachment of carbohydrate chains. We describe an infant with the phenotype of a congenital muscular dystrophy, with bo
Autor:
William C. Sessa, Jeffrey S. Rush, Kenneth D. Harrison, Eon Joo Park, Andrew Kuo, Ningguo Gao, Charles J. Waechter, Mark A. Lehrman
Publikováno v:
The EMBO Journal. 30:2490-2500
Dolichol monophosphate (Dol-P) functions as an obligate glycosyl carrier lipid in protein glycosylation reactions. Dol-P is synthesized by the successive condensation of isopentenyl diphosphate (IPP), with farnesyl diphosphate catalysed by a cis-isop
Publikováno v:
Glycobiology. 20:1585-1593
During evolution the average chain length of polyisoprenoid glycosyl carrier lipids increased from C55 (prokaryotes) to C75 (yeast) to C95 (mammalian cells). In this study, the ability of the E. coli enzyme, undecaprenyl pyrophosphate synthase (UPPS)
Publikováno v:
Journal of Biological Chemistry. 283:4087-4093
During protein N-glycosylation, dolichyl pyrophosphate (Dol-P-P) is discharged in the lumenal monolayer of the endoplasmic reticulum (ER). Dol-P-P is then cleaved to Dol-P by Dol-P-P phosphatase (DPPase). Studies with the yeast mutant cwh8Delta, lack
Autor:
Charles J. Waechter, Preetha Shridas
Publikováno v:
Journal of Biological Chemistry. 281:31696-31704
Dolichol kinase (DK) catalyzes the CTP-dependent phosphorylation of dolichol in the biosynthesis de novo and possibly the recycling of dolichyl monophosphate in yeast and mammals. A cDNA clone from human brain encoding the mammalian homologue, hDKp,