Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Charles J Russell"'
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009910 (2021)
The hemagglutinin (HA) surface glycoprotein is triggered by endosomal low pH to cause membrane fusion during influenza A virus (IAV) entry yet must remain sufficiently stable to avoid premature activation during virion transit between cells and hosts
Externí odkaz:
https://doaj.org/article/2fd411c54790405ba57981eea02ba9eb
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009299 (2021)
Human parainfluenza viruses (HPIVs) are a leading cause of acute respiratory infection hospitalization in children, yet little is known about how dose, strain, tissue tropism, and individual heterogeneity affects the processes driving growth and clea
Externí odkaz:
https://doaj.org/article/d3c9ec477df046dcad760f539c2dad11
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251473 (2021)
During influenza A virus (IAV) entry, the hemagglutinin (HA) protein is triggered by endosomal low pH to undergo irreversible structural changes that mediate membrane fusion. HA proteins from different isolates vary in the pH at which they become act
Externí odkaz:
https://doaj.org/article/fd5ce1bbbc764df4badfa0592590b8cf
Autor:
Meng Hu, Guohua Yang, Jennifer DeBeauchamp, Jeri Carol Crumpton, Hyunsuh Kim, Lei Li, Xiu-Feng Wan, Lisa Kercher, Andrew S Bowman, Robert G Webster, Richard J Webby, Charles J Russell
Publikováno v:
eLife, Vol 9 (2020)
Pandemic influenza A viruses can emerge from swine, an intermediate host that supports adaptation of human-preferred receptor-binding specificity by the hemagglutinin (HA) surface antigen. Other HA traits necessary for pandemic potential are poorly u
Externí odkaz:
https://doaj.org/article/4c1bc8ee6dde4d268e1f6f2f4d472455
Autor:
Luis Martinez-Sobrido, Pilar Blanco-Lobo, Laura Rodriguez, Theresa Fitzgerald, Hanyuan Zhang, Phuong Nguyen, Christopher S Anderson, Jeanne Holden-Wiltse, Sanjukta Bandyopadhyay, Aitor Nogales, Marta L DeDiego, Brian R Wasik, Benjamin L Miller, Carole Henry, Patrick C Wilson, Mark Y Sangster, John J Treanor, David J Topham, Lauren Byrd-Leotis, David A Steinhauer, Richard D Cummings, Jasmina M Luczo, Stephen M Tompkins, Kaori Sakamoto, Cheryl A Jones, John Steel, Anice C Lowen, Shamika Danzy, Hui Tao, Ashley L Fink, Sabra L Klein, Nicholas Wohlgemuth, Katherine J Fenstermacher, Farah El Najjar, Andrew Pekosz, Lauren Sauer, Mitra K Lewis, Kathryn Shaw-Saliba, Richard E Rothman, Zhen-Ying Liu, Kuan-Fu Chen, Colin R Parrish, Ian E H Voorhees, Yoshihiro Kawaoka, Gabriele Neumann, Shiho Chiba, Shufang Fan, Masato Hatta, Huihui Kong, Gongxun Zhong, Guojun Wang, Melissa B Uccellini, Adolfo García-Sastre, Daniel R Perez, Lucas M Ferreri, Sander Herfst, Mathilde Richard, Ron Fouchier, David Burke, David Pattinson, Derek J Smith, Victoria Meliopoulos, Pamela Freiden, Brandi Livingston, Bridgett Sharp, Sean Cherry, Juan Carlos Dib, Guohua Yang, Charles J Russell, Subrata Barman, Richard J Webby, Scott Krauss, Angela Danner, Karlie Woodard, Malik Peiris, R A P M Perera, M C W Chan, Elena A Govorkova, Bindumadhav M Marathe, Philippe N Q Pascua, Gavin Smith, Yao-Tsun Li, Paul G Thomas, Stacey Schultz-Cherry
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008409 (2020)
The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) hav
Externí odkaz:
https://doaj.org/article/a276b3ba47c444b9b66890d5fe29aa86
Autor:
Marion Russier, Guohua Yang, Atanaska Marinova-Petkova, Peter Vogel, Bryan S Kaplan, Richard J Webby, Charles J Russell
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006276 (2017)
A pandemic-capable influenza virus requires a hemagglutinin (HA) surface glycoprotein that is immunologically unseen by most people and is capable of supporting replication and transmission in humans. HA stabilization has been linked to 2009 pH1N1 pa
Externí odkaz:
https://doaj.org/article/30cf9803ce4f41c0b26260c55c8343c5
Autor:
Marc Lipsitch, Wendy Barclay, Rahul Raman, Charles J Russell, Jessica A Belser, Sarah Cobey, Peter M Kasson, James O Lloyd-Smith, Sebastian Maurer-Stroh, Steven Riley, Catherine AA Beauchemin, Trevor Bedford, Thomas C Friedrich, Andreas Handel, Sander Herfst, Pablo R Murcia, Benjamin Roche, Claus O Wilke, Colin A Russell
Publikováno v:
eLife, Vol 5 (2016)
The threat of an influenza A virus pandemic stems from continual virus spillovers from reservoir species, a tiny fraction of which spark sustained transmission in humans. To date, no pandemic emergence of a new influenza strain has been preceded by d
Externí odkaz:
https://doaj.org/article/b177bbbe82ff40c7ba95daee77f926c1
Publikováno v:
PLoS Pathogens, Vol 12, Iss 9, p e1005875 (2016)
In immunocompromised patients, parainfluenza virus (PIV) infections have an increased potential to spread to the lower respiratory tract (LRT), resulting in increased morbidity and mortality. Understanding the immunologic defects that facilitate vira
Externí odkaz:
https://doaj.org/article/53ddb8e343514b7a82a5806fc6a3cdd7
Autor:
Rabeh El-Shesheny, John Franks, Ahmed Kandeil, Rebecca Badra, Jasmine Turner, Patrick Seiler, Bindumadhav M. Marathe, Trushar Jeevan, Lisa Kercher, Meng Hu, Yul Eum Sim, Kenrie P. Y. Hui, Michael C. W. Chan, Andrew J. Thompson, Pamela McKenzie, Elena A. Govorkova, Charles J. Russell, Peter Vogel, James C. Paulson, J. S. Malik Peiris, Robert G. Webster, Mohamed A. Ali, Ghazi Kayali, Richard J. Webby
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract In 2017, a novel influenza A virus (IAV) was isolated from an Egyptian fruit bat. In contrast to other bat influenza viruses, the virus was related to avian A(H9N2) viruses and was probably the result of a bird-to-bat transmission event. To
Externí odkaz:
https://doaj.org/article/0e383400a9d3481ebc14bb85730eae93
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003151 (2013)
The influenza A virus (IAV) HA protein must be activated by host cells proteases in order to prime the molecule for fusion. Consequently, the availability of activating proteases and the susceptibility of HA to protease activity represents key factor
Externí odkaz:
https://doaj.org/article/e4ca1d24a55049dd8d60ea9a20c11305