Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Charles J Parker"'
Autor:
Colin P Farrell, Jessica R Overbey, Hetanshi Naik, Danielle Nance, Gordon D McLaren, Christine E McLaren, Luming Zhou, Robert J Desnick, Charles J Parker, John D Phillips
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163322 (2016)
Both familial and sporadic porphyria cutanea tarda (PCT) are iron dependent diseases. Symptoms of PCT resolve when iron stores are depleted by phlebotomy, and a sequence variant of HFE (C282Y, c.843G>A, rs1800562) that enhances iron aborption by redu
Externí odkaz:
https://doaj.org/article/ce3d2d5c55b04405afc0ca956d1f0a42
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Normal human red blood cells have an average life span of about 120 days in the circulation after which they are engulfed by macrophages. This is an extremely efficient process as macrophages phagocytose about 5 million erythrocytes every second with
Externí odkaz:
https://doaj.org/article/6f25fb0ee467429eba7473b6c13906fa
Autor:
James C. Barton, Christine E. McLaren, Wen-pin Chen, Grant A. Ramm, Gregory J. Anderson, Lawrie W. Powell, V. Nathan Subramaniam, Paul C. Adams, Pradyumna D. Phatak, Lyle C. Gurrin, John D. Phillips, Charles J. Parker, Mary J. Emond, Gordon D. McLaren
Publikováno v:
Annals of Hepatology, Vol 17, Iss 5, Pp 871-879 (2018)
Introduction and aim. We sought to identify independent risk factors for cirrhosis in HFE p.C282Y homozygotes in a cross-sectional study.Material and methods. We evaluated 368 p.C282Y homozygotes who underwent liver biopsy and compared characteristic
Externí odkaz:
https://doaj.org/article/b614345361c84b339e0dc7dc77a70630
Autor:
Jennie Vagher, Bryan D. Huber, Luke Maese, Archana M Agarwal, Afaf Osman, Ami B. Patel, Tsewang Tashi, Paul J Shami, Tibor Kovacsovics, Julie D. Asch, Charles J. Parker, Srinivas K. Tantravahi
Publikováno v:
Blood. 140:11468-11470
Autor:
Jérôme Lamoril, Dimitri Tchernitchko, Robert J. Desnick, Charles J. Parker, Hervé Puy, Laurent Gouya, Brenden Chen, Zoubida Karim, Gaël Nicolas, Colin P. Farrell, John D. Phillips
Publikováno v:
Blood Advances
Blood Advances, The American Society of Hematology, 2021, ⟨10.1182/bloodadvances.2021005484⟩
Blood Advances, The American Society of Hematology, 2021, ⟨10.1182/bloodadvances.2021005484⟩
The Mendelian inheritance pattern of acute intermittent porphyria, hereditary coproporphyria, and variegate porphyria is autosomal dominant, but the clinical phenotype is heterogeneous. Within the general population, penetrance is low, but among firs
Autor:
D Karl E Anderson, Paula Aguilera-Peiró, Laurent Gouya, David J. Kuter, Charles J. Parker, Zhaowei Hua, Marianne T. Sweetser, Herbert L. Bonkovsky, Penelope E. Stein, Bruce Ritchie, Envision Investigators, Manisha Balwani, John J. Ko, Eliane Sardh, Paolo Ventura, Susana Monroy, D. Montgomery Bissell, Jeeyoung Oh
Publikováno v:
Liver International. 42:161-172
Background & aims Upregulation of hepatic delta-aminolevulinic acid synthase 1 with accumulation of potentially toxic heme precursors delta-aminolevulinic acid and porphobilinogen is fundamental to the pathogenesis of acute hepatic porphyria. Aims ev
Autor:
Laurent Gouya, Robert J. Desnick, Montgomery D. Bissel, Manisha Balwani, Charles J. Parker, Karl E. Anderson, John D. Phillips, Joseph R. Bloomer, Hervé Puy, Ashwani K. Singal
Publikováno v:
Mol Genet Metab
Erythropoietic protoporphyria (EPP), the most common porphyria of childhood and the third most common porphyria of adulthood, is characterized clinically by painful, non-blistering cutaneous photosensitivity. Two distinct inheritance patterns involvi
Autor:
Josef T. Prchal, Michael W. Deininger, Ming Y. Lim, Charles J. Parker, Mouhamed Yazan Abou-Ismail
Publikováno v:
Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 32(8)
Portal hypertension (pHTN) complicates myeloproliferative neoplasms (MPNs), and usually occurs due to Budd-Chiari syndrome or splanchnic vein thrombosis. Current management modalities for MPN-associated pHTN include anticoagulation, transjugular intr
Autor:
David J. Kuter, S Rhyee, Charles J. Parker, Manisha Balwani, Samuel M. Silver, David C. Rees, Sioban Keel, Paolo Ventura, Ulrich Stölzel, Laurent Gouya
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 43, Iss, Pp S5-S6 (2021)
Introduction Acute hepatic porphyria (AHP) is a family of rare genetic diseases due to enzyme defects in hepatic heme biosynthesis. ENVISION is an ongoing phase 3 study, evaluating efficacy and safety of givosiran in symptomatic AHP patients. Objecti
Autor:
Charles J. Parker, Dean Roemmich, Michael C. McClune, Kyle R. Grindley, Russ E. Davis, David N. Black, John Gilson, N. V. Zilberman, Sarah G. Purkey, Philip Sutton, Jeffrey T. Sherman
Publikováno v:
Journal of Atmospheric and Oceanic Technology. 36:1967-1981
Deployment of Deep Argo regional pilot arrays is underway as a step toward a global array of 1250 surface-to-bottom profiling floats embedded in the upper-ocean (2000 m) Argo Program. Of the 80 active Deep Argo floats as of July 2019, 55 are Deep Sou