Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Charles J, Frazier"'
Autor:
Jeffrey S. Thinschmidt, Scott W. Harden, Michael A. King, James D. Talton, Charles J. Frazier
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
We established a novel brain slice assay to test the ability of acetylcholinesterase (AChE) reactivators to prevent ACh-induced M1 muscarinic acetylcholine receptor (mAChR) dependent hyperexcitability observed after exposure to the organophosphate (O
Externí odkaz:
https://doaj.org/article/3545c7d60f87475388b0638bb2d7565a
Autor:
Khalid Elsaafien, Scott W. Harden, Dominique N. Johnson, Aecha K. Kimball, Wanhui Sheng, Justin A. Smith, Karen A. Scott, Charles J. Frazier, Annette D. de Kloet, Eric G. Krause
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The brain maintains cardiovascular homeostasis, in part, via the arterial baroreflex which senses changes in blood pressure (BP) at the level of the aortic arch. Sensory afferents innervating the aortic arch employ baroreceptors to convert stretch ex
Externí odkaz:
https://doaj.org/article/0d05e03e04494f7ea60e27dbb7215a69
Autor:
Yuning Liu, Hong Xing, Wanhui Sheng, Kyle N. Singh, Alexandra G. Korkmaz, Caroline Comeau, Maisha Anika, Alexis Ernst, Fumiaki Yokoi, David E. Vaillancourt, Charles J. Frazier, Yuqing Li
Publikováno v:
Neurobiology of Disease, Vol 154, Iss , Pp 105342- (2021)
Dystonia is a neurological movement disorder characterized by sustained or intermittent muscle contractions, repetitive movement, and sometimes abnormal postures. DYT1 dystonia is one of the most common genetic dystonias, and most patients carry hete
Externí odkaz:
https://doaj.org/article/8236ce4e236641d7869644a27c28edb8
Publikováno v:
eLife, Vol 10 (2021)
Hypothalamic oxytocinergic magnocellular neurons have a fascinating ability to release peptide from both their axon terminals and from their dendrites. Existing data indicates that the relationship between somatic activity and dendritic release is no
Externí odkaz:
https://doaj.org/article/19dfdf9a26634505adf3a81dff24a0a3
Autor:
Caesar M Hernandez, Caitlin A Orsini, Chase C Labiste, Alexa-Rae Wheeler, Tyler W Ten Eyck, Matthew M Bruner, Todd J Sahagian, Scott W Harden, Charles J Frazier, Barry Setlow, Jennifer L Bizon
Publikováno v:
eLife, Vol 8 (2019)
Across species, aging is associated with an increased ability to choose delayed over immediate gratification. These experiments used young and aged rats to test the role of the basolateral amygdala (BLA) in intertemporal decision making. An optogenet
Externí odkaz:
https://doaj.org/article/69ee7725cacd4768938b686075c7c79c
Autor:
Leah M. Truckenbrod, Sara M. Betzhold, Alexa-Rae Wheeler, John Shallcross, Sarthak Singhal, Scott Harden, Marek Schwendt, Charles J. Frazier, Jennifer L. Bizon, Barry Setlow, Caitlin A. Orsini
Publikováno v:
bioRxiv
Decision making is a complex cognitive process that recruits a distributed network of brain regions, including the basolateral amygdala (BLA) and nucleus accumbens shell (NAcSh). Recent work suggests that communication between these structures, as we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57555519ef409cdfc0740cca3690d1ab
https://doi.org/10.1101/2023.01.15.524142
https://doi.org/10.1101/2023.01.15.524142
Autor:
Jeffrey S, Thinschmidt, Scott W, Harden, Michael A, King, James D, Talton, Charles J, Frazier
Publikováno v:
Frontiers in cellular neuroscience. 16
We established a novel brain slice assay to test the ability of acetylcholinesterase (AChE) reactivators to prevent ACh-induced M1 muscarinic acetylcholine receptor (mAChR) dependent hyperexcitability observed after exposure to the organophosphate (O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0c0019a3170b82e68bdf4e2747f9678
https://pubmed.ncbi.nlm.nih.gov/36479275
https://pubmed.ncbi.nlm.nih.gov/36479275
Autor:
Khalid Elsaafien, Sophia A Eikenberry, Scott W Harden, Wanhui Sheng, Karen A Scott, Charles J Frazier, Colin Sumners, Eric G Krause, Annette D De Kloet
Publikováno v:
Hypertension. 79
Blood pressure (BP) is under constant control and regulation by an extensive neural network that spans a number of brain regions. This includes the median preoptic nucleus (MnPO) which directly projects to the pre-autonomic neurons of the hypothalamu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53ac4d49d70a6473ffbc523e74bd70ab
https://doi.org/10.1161/hyp.79.suppl_1.060
https://doi.org/10.1161/hyp.79.suppl_1.060
Autor:
Eliot A. Spector, Dominique Johnson, U. Muscha Steckelings, Wanhui Sheng, Michael Bader, Khalid Elsaafien, Colin Sumners, Scott W Harden, Charles J. Frazier, Lei Wang, Mazher Mohammed, Eric G. Krause, Karen A. Scott, Annette D. de Kloet
Publikováno v:
Cardiovasc Res
Mohammed, M, Johnson, D N, Wang, L A, Harden, S W, Sheng, W, Spector, E A, Elsaafien, K, Bader, M, Steckelings, U M, Scott, K A, Frazier, C J, Sumners, C, Krause, E G & de Kloet, A D 2022, ' Targeting angiotensin type-2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice ', Cardiovascular Research, vol. 118, no. 3, pp. 883-896 . https://doi.org/10.1093/cvr/cvab085
Mohammed, M, Johnson, D N, Wang, L A, Harden, S W, Sheng, W, Spector, E A, Elsaafien, K, Bader, M, Steckelings, U M, Scott, K A, Frazier, C J, Sumners, C, Krause, E G & de Kloet, A D 2022, ' Targeting angiotensin type-2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice ', Cardiovascular Research, vol. 118, no. 3, pp. 883-896 . https://doi.org/10.1093/cvr/cvab085
Aims These studies evaluate whether angiotensin type-2 receptors (AT2Rs) that are expressed on γ-aminobutyric acid (GABA) neurons in the nucleus of the solitary tract (NTS) represent a novel endogenous blood pressure lowering mechanism. Methods and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01aac8c2f28e2d59aaf124a742553095
https://doi.org/10.1093/cvr/cvab085
https://doi.org/10.1093/cvr/cvab085
Autor:
Charles J. Frazier, Karen A. Scott, Scott W Harden, Dominique Johnson, Justin A. Smith, Eliot A. Spector, Wanhui Sheng, Amy R. Alleyne, Mazher Mohammed, Eric G. Krause, Annette D. de Kloet, Khalid Elsaafien
Publikováno v:
J Neurosci
Blood pressure is controlled by endocrine, autonomic, and behavioral responses that maintain blood volume and perfusion pressure at levels optimal for survival. Although it is clear that central angiotensin type 1a receptors (AT1aR; encoded by theAgt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e1ae465282ae455a5dfa4c7679f6fe
https://doi.org/10.1523/jneurosci.1600-20.2020
https://doi.org/10.1523/jneurosci.1600-20.2020