Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma.

Autor: Ahmed Z El-Hashim, Maitham A Khajah, Rhema S Babyson, Waleed M Renno, Charles I Ezeamuzie, Ibrahim F Benter, Saghir Akhtar

Publikováno v: PLoS ONE, Vol 14, Iss 11, p e0224163 (2019)

The angiotensin-(1-7) [Ang-(1-7)]/MAS1 receptor signaling axis is a key endogenous anti-inflammatory signaling pathway. However, the mechanisms by which its mediates the anti-inflammatory effects are not completely understood. Using an allergic murin

Externí odkaz: https://doaj.org/article/05fff90a4022440da81a901e0995fc3f

Synthesis and structure-activity relationships of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives as 5-lipoxygenase inhibitors

Autor: Mira Bosso, Oludotun A. Phillips, Charles I. Ezeamuzie

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1471-1482 (2020)
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record

Oxazolidinone hydroxamic acid derivatives were synthesised and evaluated for inhibitory activity against leukotriene (LT) biosynthesis in three in vitro cell-based test systems and on direct inhibition of recombinant human 5-lipoxygenase (5-LO). Thir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191f924ed121c6ec63449be6ce5b9b97
https://doaj.org/article/dbc11757638142b588f7c508358faa22

Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma

Autor: Charles I. Ezeamuzie, Maitham A. Khajah, Ibrahim F. Benter, Ahmed Z. El-Hashim, Waleed M. Renno, Saghir Akhtar, Rhema S. Babyson

Publikováno v: PLoS ONE, Vol 14, Iss 11, p e0224163 (2019)
PLoS ONE

The angiotensin-(1–7) [Ang-(1–7)]/MAS1 receptor signaling axis is a key endogenous anti-inflammatory signaling pathway. However, the mechanisms by which its mediates the anti-inflammatory effects are not completely understood. Using an allergic m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194c33ff8e1394e40a8de261a43c1374
https://hdl.handle.net/10576/12393

Antiallergic and Antiasthmatic Effects of a Novel Enhydrazinone Ester (CEE-1): Inhibition of Activation of Both Mast Cells and Eosinophils

Autor: Charles I. Ezeamuzie, Ahmed Z. El-Hashim, Ivan O. Edafiogho, Waleed M. Renno

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 350:444-454

Activation of mast cells and eosinophils is a fundamental process in the pathophysiology of allergic diseases. We have previously reported that the novel enhydrazinone ester CEE-1 (ethyl 4-phenylhydrazinocyclohex-3-en-2-oxo-6-phenyl-1-oate) possesses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149276b5a8b2c69dab4de4bba4a9531d
https://doi.org/10.1124/jpet.114.213751

Loss of surface beta-2 adrenoceptors accounts for the insensitivity of cultured human monocytes to beta-2 adrenoceptor agonists

Autor: Reem Al-Radwan, Charles I. Ezeamuzie, Puthiyaveetil K. Shihab

Publikováno v: International Immunopharmacology. 11:1189-1194

The short-acting beta-2 adrenoceptor agonists (β(2)-agonists), such as salbutamol, are effective bronchodilators used to treat asthma. They lack significant anti-inflammatory effect in vivo as well as on isolated alveolar macrophages even though the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4592590a85f25ba6f86743c4569a0341
https://doi.org/10.1016/j.intimp.2011.03.017