Zobrazeno 1 - 10
of 445
pro vyhledávání: '"Charles H. Lang"'
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Introduction Because of the strong correlation between the blood concentration of circulating resistin and the illness severity of septic patients, resistin has been proposed as a mediator of sepsis pathophysiology. In vitro data indicate that human
Externí odkaz:
https://doaj.org/article/cd99ae7c8ca94792ab61b6a013681513
Autor:
Lauren Miller, Kai Singbartl, Zissis C. Chroneos, Victor Ruiz-Velasco, Charles H. Lang, Anthony Bonavia
Publikováno v:
Intensive Care Medicine Experimental, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Background Sepsis-induced immunosuppression is a key factor contributing to the morbidity and mortality of critically ill patients, and polymorphonuclear neutrophil dysfunction is believed to be a hallmark of this immunosuppression. Circulat
Externí odkaz:
https://doaj.org/article/0f13818e2bf14702af1af69ad6800ead
Publikováno v:
Nutrients, Vol 13, Iss 4, p 1236 (2021)
The Ragulator protein complex is critical for directing the Rag GTPase proteins and mTORC1 to the lysosome membrane mediating amino acid-stimulated protein synthesis. As there is a lack of evidence on alcohol’s effect on the Rag-Ragulator complex a
Externí odkaz:
https://doaj.org/article/4aa62d7df37a415ea23b66e425ef1455
Publikováno v:
Biomolecules, Vol 5, Iss 4, Pp 2223-2246 (2015)
Alcohol has profound effects on tissue and whole-body fuel metabolism which contribute to the increased morbidity and mortality in individuals with alcohol use disorder. This review focuses on the glucose metabolic effects of alcohol, primarily in th
Externí odkaz:
https://doaj.org/article/87d4a53ccc5f4bbb9028f64d408b7453
Autor:
Jennifer L. Steiner, Charles H. Lang
Publikováno v:
Biomolecules, Vol 7, Iss 1, p 16 (2017)
Chronic alcohol consumption perturbs lipid metabolism as it increases adipose tissue lipolysis and leads to ectopic fat deposition within the liver and the development of alcoholic fatty liver disease. In addition to the recognition of the role of ad
Externí odkaz:
https://doaj.org/article/1407747abcc042dcbde612986c76ea04
Autor:
Paul A. Roberson, Gregory N. Kincheloe, Jaclyn E. Welles, Dandan Xu, Mahalia Sam-Clarke, Paul S. MacLean, Charles H. Lang, Leonard S. Jefferson, Scot R. Kimball
Publikováno v:
The Journal of Nutrition. 153:988-998
Autor:
Charles H. Lang
Publikováno v:
Shock. 59:214-223
Publikováno v:
J Orthop Res
We examined the hypothesis that exaggerating unloading-induced bone loss using a combination of hindlimb suspension (HLS) and exogenous injections of receptor activator of nuclear factor kappa-B ligand (RANKL) also exaggeratesgastrocnemius and quadri
Publikováno v:
Inflammation
Inflammation in muscle induces the synthesis of mediators that can impair protein synthesis and enhance proteolysis, and when sustained lead to muscle atrophy. Furthermore, muscle-derived mediators that are secreted may participate in disrupting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f8fea93ebfe89bb25ec29c3c6aaab2
https://europepmc.org/articles/PMC9106851/
https://europepmc.org/articles/PMC9106851/
Autor:
Karyn A. Esser, Jennifer L. Steiner, Michael L. Rossetti, Bradley S. Gordon, Joseph A. Laudato, Charles H. Lang, Cynthia Vied, Abigail L. Tice, Choogon Lee, Christopher A. Wolff
Publikováno v:
Am J Physiol Endocrinol Metab
Circadian rhythms are central to optimal physiological function, as disruption contributes to the development of several chronic diseases. Alcohol (EtOH) intoxication disrupts circadian rhythms within liver, brain, and intestines, but it is unknown w