Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Charles H. Greenberg"'
Autor:
Rohun Kshirsagar, Li-Yen Hsu, Charles H. Greenberg, Matthew McClelland, Anushadevi Mohan, Wideet Shende, Nicolas P. Tilmans, Min Guo, Ankit Chheda, Meredith Trotter, Shonket Ray, Miguel Alvarado
Publikováno v:
Proceedings of the AAAI Conference on Artificial Intelligence. 35:15127-15136
Health insurance companies cover half of the United States population through commercial employer-sponsored health plans and pay 1.2 trillion US dollars every year to cover medical expenses for their members. The actuary and underwriter roles at a he
Autor:
Philip J Robinson, Michael J Trnka, Riccardo Pellarin, Charles H Greenberg, David A Bushnell, Ralph Davis, Alma L Burlingame, Andrej Sali, Roger D Kornberg
Publikováno v:
eLife, Vol 4 (2015)
The 21-subunit Mediator complex transduces regulatory information from enhancers to promoters, and performs an essential role in the initiation of transcription in all eukaryotes. Structural information on two-thirds of the complex has been limited t
Externí odkaz:
https://doaj.org/article/321bb9b4244c4f72aa2883d1a6beba2b
Autor:
Charles H Greenberg, Matthew P Frosch, Joshua N Goldstein, Jonathan Rosand, Steven M Greenberg
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48458 (2012)
The mechanism for hemorrhage enlargement in the brain, a key determinant of patient outcome following hemorrhagic stroke, is unknown. We performed computer-based stochastic simulation of one proposed mechanism, in which hemorrhages grow in "domino" f
Externí odkaz:
https://doaj.org/article/de2d19e39a6c43398a181733593c3281
Autor:
Riccardo Pellarin, Ilona Nudelman, Zhiheng Yu, Brian T. Chait, Joanna A. Hogan, Brian D. Slaughter, Javier Fernandez-Martinez, Seung Joong Kim, Jennifer L. Gerton, Charles H. Greenberg, Rosemary Williams, Paula Upla, Barak Raveh, Steven J. Ludtke, Ignacia Echeverria, David L. Stokes, Andrej Sali, Azraa S. Chaudhury, John D. Aitchison, Wenzhu Zhang, Manjunatha Shivaraju, Jay R. Unruh, Thurston Herricks, Christopher W. Akey, Erica Y. Jacobs, Ilan E. Chemmama, Yi Shi, Martin F. Jarrold, Roxana Mironska, Michael P. Rout, M. Jason de la Cruz, Junjie Wang
Publikováno v:
Nature
Nature, Nature Publishing Group, 2018, 555 (7697), pp.475-482. ⟨10.1038/nature26003⟩
Nature, 2018, 555 (7697), pp.475-482. ⟨10.1038/nature26003⟩
Nature, Nature Publishing Group, 2018, 555 (7697), pp.475-482. ⟨10.1038/nature26003⟩
Nature, 2018, 555 (7697), pp.475-482. ⟨10.1038/nature26003⟩
Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport between the cytoplasm and nucleoplasm. However, their large size and dynamic nature have impeded a full structural and functional elucidation. Here we determined th
Autor:
Shruthi Viswanath, Massimiliano Bonomi, Andrej Sali, Daniel J. Saltzberg, Benjamin Webb, Riccardo Pellarin, Charles H. Greenberg
Publikováno v:
Protein Science. 27:245-258
Building models of a biological system that are consistent with the myriad data available is one of the key challenges in biology. Modeling the structure and dynamics of macromolecular assemblies, for example, can give insights into how biological sy
Autor:
Charles H. Greenberg, Andrej Sali, Daniel J. Saltzberg, Ben Webb, Ignacia Echeverria, Shruthi Viswanath, Ilan E. Chemmama, Riccardo Pellarin
Publikováno v:
Methods in Molecular Biology ISBN: 9781493996070
Integrative structure modeling provides 3D models of macromolecular systems that are based on information from multiple types of experiments, physical principles, statistical inferences, and prior structural models. Here, we provide a hands-on realis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07f2e99aae70f11e7f0f4ce9f7256488
https://doi.org/10.1007/978-1-4939-9608-7_15
https://doi.org/10.1007/978-1-4939-9608-7_15
Autor:
Michael J. MacCoss, Justin M. Kollman, Richard J. Johnson, Trisha N. Davis, Charles H. Greenberg, Alex Zelter, David A. Agard, Andrej Sali
Publikováno v:
Journal of structural biology, vol 194, iss 3
Modeling protein complex structures based on distantly related homologues can be challenging due to poor sequence and structure conservation. Therefore, utilizing even low-resolution experimental data can significantly increase model precision and ac
Autor:
Christopher C. Ebmeier, Steven Hahn, Vishnu Raman, Andrej Sali, Bong Yoon Kim, Dylan J. Taatjes, Peter Cimermancic, Jie Luo, Charles H. Greenberg, Riccardo Pellarin, Shruthi Viswanath, Jeff Ranish, Marine Dehecq
Publikováno v:
Molecular cell, vol 59, iss 5
TFIIH is essential for both RNA polymerase II transcription and DNA repair, and mutations in TFIIH can result in human disease. Here, we determine the molecular architecture of human and yeast TFIIH by an integrative approach using chemical crosslink
Autor:
Alex Zelter, Justin M. Kollman, Andrej Sali, John V. Kilmartin, Trisha N. Davis, David A. Agard, Kimberly K. Fong, Charles H. Greenberg, Sam Li, Michelle Moritz, José-Jesús Fernández
Publikováno v:
Nature structural & molecular biology
Agard, David; Sali, Andrej; Kollman, JM; Greenberg, CH; Li, S; Moritz, M; et al.(2015). Ring closure activates yeast γTuRC for species-specific microtubule nucleation. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1v12x8f7
Agard, David; Sali, Andrej; Kollman, JM; Greenberg, CH; Li, S; Moritz, M; et al.(2015). Ring closure activates yeast γTuRC for species-specific microtubule nucleation. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/1v12x8f7
The γ-tubulin ring complex (γTuRC) is the primary microtubule nucleator in cells. γTuRC is assembled from repeating γ-tubulin small complex (γTuSC) subunits and is thought to function as a template by presenting a γ-tubulin ring that mimics mic
Autor:
Michael Nilges, Riccardo Pellarin, Michele Vendruscolo, Samuel Hanot, Andrej Sali, Massimiliano Bonomi, Charles H. Greenberg
Publikováno v:
Structure
Structure, 2019, 27 (1), pp.175-188.e6. ⟨10.1016/j.str.2018.09.011⟩
Structure, Elsevier (Cell Press), 2019, 27 (1), pp.175-188.e6. ⟨10.1016/j.str.2018.09.011⟩
Structure, 2019, 27 (1), pp.175-188.e6. ⟨10.1016/j.str.2018.09.011⟩
Structure, Elsevier (Cell Press), 2019, 27 (1), pp.175-188.e6. ⟨10.1016/j.str.2018.09.011⟩
SummaryCryo-electron microscopy (cryo-EM) has become a mainstream technique for determining the structures of complex biological systems. However, accurate integrative structural modeling has been hampered by the challenges in objectively weighing cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbcf65ff87b7a920724da86855506462