Výsledky vyhledávání - "Charles H. Fraga"

Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier

Autor: Jun Shen, Vishal S. Narang, Clinton F. Stewart, Christopher M. Waters, Narendra Kumar, Charles H. Fraga, Stacy L. Throm

Publikováno v: American Journal of Physiology-Cell Physiology. 295:C440-C450

Brain edema is an important factor leading to morbidity and mortality associated with primary brain tumors. Dexamethasone, a synthetic glucocorticoid, is routinely prescribed with antineoplastic agents to alleviate pain associated with chemotherapy a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae3b115a8772c6a2b85f06e18017eaa3
https://doi.org/10.1152/ajpcell.00491.2007

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UGT1A1Promoter Genotype Correlates With SN-38 Pharmacokinetics, but Not Severe Toxicity in Patients Receiving Low-Dose Irinotecan

Autor: Charles H. Fraga, Tiebin Liu, Lisa M. McGregor, Stacy L. Throm, Clinton F. Stewart, Catherine A. Billups, Carlos Rodriguez-Galindo, Thandranese S. Owens, Amar Gajjar, Wayne L. Furman, Melinda A. O'Shaughnessy, John C. Panetta

Publikováno v: Journal of Clinical Oncology. 25:2594-2600

PurposeTo study the association between UDP-glucuronosyltransferase 1A1 (UGT1A1) genotypes and severe toxicity as well as irinotecan disposition in pediatric patients with solid tumors receiving low-dose, protracted irinotecan (15 to 75 mg/m2daily fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34340aef3ee6cfe46c00ee586bba3b8c
https://doi.org/10.1200/jco.2006.10.2301

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Determination of Cloretazine™ (VNP40101M) and its active metabolite (VNP4090CE) in human plasma by liquid chromatography electrospray tandem mass spectrometry (LC–ESI-MS/MS)

Autor: Patton Minkin, Clinton F. Stewart, Sridharan Gururangan, Melinda A. O'Shaughnessy, Feng Bai, Charles H. Fraga

Publikováno v: Journal of Chromatography B. 853:97-104

A sensitive method for the determination of Cloretazine (VNP40101M) and its metabolite (VNP4090CE) with an internal standard (ISTD) in human plasma was developed using high-performance liquid chromatographic separation with tandem mass spectrometric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d26f84888f99153f9a3e44461f7778
https://doi.org/10.1016/j.jchromb.2007.02.062

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Plasma and Cerebrospinal Fluid Pharmacokinetics of Erlotinib and Its Active Metabolite OSI-420

Autor: Matthew J. Krasin, Feng Bai, Alberto Broniscer, John C. Panetta, Melinda A. O'Shaughnessy, Amar Gajjar, Charles H. Fraga, Clinton F. Stewart

Publikováno v: Clinical Cancer Research. 13:1511-1515

Purpose: To report cerebrospinal fluid (CSF) penetration of erlotinib and its metabolite OSI-420.Experimental Design: Pharmacokinetic measurements were done in plasma (days 1, 2, 3, and 8 of therapy) and, concurrently, in plasma and CSF (before and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8590d244c373f0aaeee040469d8fe4
https://doi.org/10.1158/1078-0432.ccr-06-2372

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Proinflammatory Response of Alveolar Type II Pneumocytes to in vitro Hypoxia and Reoxygenation

Autor: Alexander S. Farivar, Michael S. Mulligan, Karen Byrne, Steven M Woolley, Charles H. Fraga

Publikováno v: American Journal of Transplantation. 4:346-351

Type II pneumocytes (T2P) are integral in preserving the integrity of the alveolar space by modulating the fluid composition surrounding the alveolar epithelium. There is also mounting evidence supporting their contribution to the development of acut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16da2b6e1f7926074f768223229495dc
https://doi.org/10.1111/j.1600-6143.2004.00352.x

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β-chemokine function in experimental lung ischemia-reperfusion injury

Autor: Alexander S. Farivar, Baiya Krishnadasan, Karen Byrne, Michael S. Mulligan, Babu V Naidu, Steven M Woolley, Charles H. Fraga

Publikováno v: The Annals of Thoracic Surgery. 77:1056-1062

Although chemokines are functionally important in models of ischemia-reperfusion injury, little is known about their role in lung ischemia-reperfusion injury (LIRI). This study examined the role of the beta-chemokines, macrophage inflammatory protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da97d9359db29db7718cb36add0aea0
https://doi.org/10.1016/s0003-4975(03)01600-x

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Enhanced peroxynitrite decomposition protects against experimental obliterative bronchiolitis

Autor: John T. Groves, Csaba Szabó, Babu V. Naidu, Steven M. Woolley, Michael S. Mulligan, Alexander S. Farivar, Andrew L. Salzman, Charles H. Fraga

Publikováno v: Experimental and Molecular Pathology. 75:12-17

Obliterative bronchiolitis (OB) affects over half of all survivors following lung or heart-lung transplantation. Respiratory epithelial cell injury, peribronchial inflammation, and proliferation of fibrovascular tissue causing airway occlusion charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e31cbb34c6219adf20a7772069c147
https://doi.org/10.1016/s0014-4800(03)00015-7

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Critical role of reactive nitrogen species in lung ischemia–reperfusion injury

Autor: Charles H. Fraga, Babu V. Naidu, Michael S. Mulligan, Edward D. Verrier, Andrew L. Salzman, Csaba Szabó

Publikováno v: The Journal of Heart and Lung Transplantation. 22:784-793

Peroxynitrite is a potent cytotoxic free radical produced by the reaction of nitric oxide with the superoxide ion produced in conditions of oxidative stress. The purpose of the study was to examine the role of this reactive nitrogen species in lung i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfc86daeaabbeb837cb04c9d3d12079
https://doi.org/10.1016/s1053-2498(02)00556-9

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ENHANCED EXPRESSION OF THE MESENCHYMAL MARKER, VIMENTIN, IN HYPERPLASTIC VERSUS NORMAL HUMAN PROSTATIC EPITHELIUM

Autor: Charles H. Fraga, David Kirk, Lawrence D. True

Publikováno v: Journal of Urology. 159:270-274

A total of 20 benign prostatic hyperplasia (BPH) tissue samples from 13 patients were evaluated for the coexpression of cytokeratins and vimentin intermediate filaments in the glandular epithelium. Vimentin expression was significantly increased (p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e27e4220dda8a1e3995af4c28e1c3f
https://doi.org/10.1016/s0022-5347(01)64080-1

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