Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Charles H. Blomquist"'
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 122:295-301
17β-Hydroxysteroid dehydrogenase/17-ketosteroid reductase (17HSD/KSR) activity and 17HSD/KSR types 1, 2, 4, and 5 mRNA levels were characterized in ovarian cancer cell lines derived from patients unexposed to radiation or chemotherapy. Activity was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7188cc3113f8ed6e2b40bff5105f7e2e
https://doi.org/10.1016/j.jsbmb.2010.06.008
https://doi.org/10.1016/j.jsbmb.2010.06.008
Autor:
Adam M. Reitzel, Jerzy Adamski, Ferdinand Haller, Ann M. Tarrant, Janina Tokarz, Charles H. Blomquist
Publikováno v:
Molecular and Cellular Endocrinology. 301:27-36
Cnidarians occupy a key evolutionary position as a sister group to bilaterian animals. While cnidarians contain a diverse complement of steroids, sterols, and other lipid metabolites, relatively little is known of the endogenous steroid metabolism or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4223e6ea5e0fe6bbcfa180014f45903d
https://doi.org/10.1016/j.mce.2008.09.037
https://doi.org/10.1016/j.mce.2008.09.037
Autor:
Justin C. Chura, Charles H. Blomquist, Hyung S. Ryu, Donald Poirier, Yves Tremblay, Doris C. Brooker, Marc Simard, Peter A. Argenta
Publikováno v:
Molecular and Cellular Endocrinology. 301:51-58
Anti-estrogen therapies for treating ovarian carcinoma have had mixed outcomes suggesting some tumors may be estrogen-dependent. We assayed the activity levels of 17beta-hydroxysteroid dehydrogenase (17beta-HSD), 3beta-hydroxysteroid dehydrogenase (3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932db596df6332a962c04ecaeb9ab3b6
https://doi.org/10.1016/j.mce.2008.07.015
https://doi.org/10.1016/j.mce.2008.07.015
Publikováno v:
Steroids. 70:507-514
Epidemiologic data suggest a relationship between dietary intake of phytochemicals and a lower incidence of some cancers. Modulation of steroid hormone metabolism has been proposed as a basis for this effect. It has been shown that aromatase, 3beta-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f650e14b4c252514ba68e56e6de42f85
https://doi.org/10.1016/j.steroids.2005.01.004
https://doi.org/10.1016/j.steroids.2005.01.004
Publikováno v:
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 136:473-485
Estrogens and androgens are steroids that act as reproductive hormones in vertebrates. These compounds have also been detected in reef-building corals and other invertebrates, where they are hypothesized to act as bioregulatory molecules. Experiments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfeac8c0e5dbdeb04e0f03194cc65e4
https://doi.org/10.1016/s1096-4959(03)00253-7
https://doi.org/10.1016/s1096-4959(03)00253-7
Autor:
Martin Bonenfant, Zoltan Posalaky, Charles H. Blomquist, Yves Tremblay, Sarah Tuli-Puri, Dennis M McGinley, Dennis G. Bealka, Lakatua Dj
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 81:343-351
17beta-Hydroxysteroid dehydrogenase/17-ketosteroid reductases (17HSD/KSR) play a key role in regulating steroid receptor occupancy in normal tissues and tumors. Although 17HSD/KSR activity has been detected in ovarian epithelial tumors, our understan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530ec0ea578075581d15fcc6d2e3bd35
https://doi.org/10.1016/s0960-0760(02)00117-6
https://doi.org/10.1016/s0960-0760(02)00117-6
Autor:
Vincenzo Bellavia, Giuseppe Montalto, Orazia M. Granata, Giuseppe Modica, Charles H. Blomquist, Giuseppe Carruba, Monica Miele, Luigi Castagnetta
Publikováno v:
Molecular and Cellular Endocrinology. 193:51-58
Sex steroid hormones are thought, among several other risk factors, to play a role in liver malignancies. For example, from epidemiological studies in hepatocellular carcinoma (HCC), a clear disadvantage for male sex is evident. In addition, elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c361d2165842ad7f2ebe57458cc41c6
https://doi.org/10.1016/s0303-7207(02)00095-3
https://doi.org/10.1016/s0303-7207(02)00095-3
Autor:
Renée Drolet, Peter T. D'Ascoli, Charles H. Blomquist, Yves Tremblay, Martin Bonenfant, Pierre R. Provost
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 85:4841-4850
Progesterone and estradiol are the most potent human sex steroid hormones of placental origin and are essential to the maintenance of pregnancy, the timing of parturition, the maturation of many fetal organs, and the preparation of the maternal repro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f23c01c310fb21394afde222393c84d
https://doi.org/10.1210/jcem.85.12.7040
https://doi.org/10.1210/jcem.85.12.7040
Autor:
Orazia M. Granata, Monika Markus, Luigi Castagnetta, Jerzy Adamski, Charles H. Blomquist, Giuseppe Carruba, Adele Traina, Michele Pavone-Macaluso
Publikováno v:
Endocrinology. 138:4876-4882
The 17beta-hydroxysteroid dehydrogenase (17betaHSD) enzyme system governs important redox reactions at the C17 position of steroid hormones. Different 17betaHSD types (no. 1-4) have been identified to date in peripheral human tissues, such as placent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52876e1aa1a3372fdddcb5bbd7e56d6c
https://doi.org/10.1210/endo.138.11.5497
https://doi.org/10.1210/endo.138.11.5497
Publikováno v:
Journal of Cellular Biochemistry. 59:409-417
Although there is a growing body of evidence that 17β-hydroxysteroid oxidoteductase plays a role the regulation of steroid levels in epithelial tumors of the endometrium and breast, out knowledge of its role in other gynecologic tumors is limited. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294fff634faa59232c76aa9b732c19d1
https://doi.org/10.1002/jcb.240590402
https://doi.org/10.1002/jcb.240590402