Zobrazeno 1 - 10
of 703
pro vyhledávání: '"Charles G. Eberhart"'
Autor:
Kandarp Joshi, Menglang Yuan, Keisuke Katsushima, Olivier Saulnier, Animesh Ray, Ernest Amankwah, Stacie Stapleton, George Jallo, Michael D. Taylor, Charles G. Eberhart, Ranjan J. Perera
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-14 (2024)
Abstract Medulloblastoma, the most common malignant pediatric brain tumor, is classified into four main molecular subgroups, but group 3 and group 4 tumors are difficult to subclassify and have a poor prognosis. Rapid point-of-care diagnostic and pro
Externí odkaz:
https://doaj.org/article/326f988b197f4347bf4fff9b3108c6a0
Autor:
Menglang Yuan, Iqbal Mahmud, Keisuke Katsushima, Kandarp Joshi, Olivier Saulnier, Rudramani Pokhrel, Bongyong Lee, Wathsala Liyanage, Haritha Kunhiraman, Stacie Stapleton, Ignacio Gonzalez-Gomez, Rangaramanujam M. Kannan, Tanja Eisemann, Elayaraja Kolanthai, Sudipta Seal, Timothy J. Garrett, Saed Abbasi, Kimberly Bockley, Justin Hanes, Prem Chapagain, George Jallo, Robert J. Wechsler-Reya, Michael D. Taylor, Charles G. Eberhart, Animesh Ray, Ranjan J. Perera
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract The prognosis of childhood medulloblastoma (MB) is often poor, and it usually requires aggressive therapy that adversely affects quality of life. microRNA-211 (miR-211) was previously identified as an important regulator of cells that descen
Externí odkaz:
https://doaj.org/article/d02fc40d411f4baba42e490fbec01155
Autor:
Su-Chan Lee, Cornelia Peterson, Kaixuan Wang, Lujain Alaali, James Eshleman, Nicholas R. Mahoney, Emily Li, Charles G. Eberhart, Ashley A. Campbell
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10183 (2024)
Ocular adnexal sebaceous carcinoma (SebCA) represents one of the most clinically problematic periocular tumors, often requiring aggressive surgical resection. The pathobiology of this tumor remains poorly understood, and few models exist that are sui
Externí odkaz:
https://doaj.org/article/a6ac04bb0cdb435292b07ba79fac30d2
Autor:
Keisuke Katsushima, Kandarp Joshi, Menglang Yuan, Brigette Romero, Mona Batish, Stacie Stapleton, George Jallo, Elayaraja Kolanthai, Sudipta Seal, Olivier Saulnier, Michael D. Taylor, Robert J. Wechsler-Reya, Charles G. Eberhart, Ranjan J. Perera
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113938- (2024)
Summary: Recent studies suggest that long non-coding RNAs (lncRNAs) contribute to medulloblastoma (MB) formation and progression. We have identified an lncRNA, lnc-HLX-2-7, as a potential therapeutic target in group 3 (G3) MBs. lnc-HLX-2-7 RNA specif
Externí odkaz:
https://doaj.org/article/4f95873122404b64823c7c17eb939dbe
Autor:
Natalia Muñoz Perez, Juliana M. Pensabene, Phillip M. Galbo, Negar Sadeghipour, Joanne Xiu, Kirsten Moziak, Rita M. Yazejian, Rachel L. Welch, W. Robert Bell, Soma Sengupta, Sonikpreet Aulakh, Charles G. Eberhart, David M. Loeb, Emad Eskandar, Deyou Zheng, Xingxing Zang, Allison M. Martin
Publikováno v:
Cancers, Vol 16, Iss 15, p 2629 (2024)
Background: Relapsed medulloblastoma (MB) poses a significant therapeutic challenge due to its highly immunosuppressive tumor microenvironment. Immune checkpoint inhibitors (ICIs) have struggled to mitigate this challenge, largely due to low T-cell i
Externí odkaz:
https://doaj.org/article/5692449a153e48c39d5222e51d78108a
Autor:
Keisuke Katsushima, Rudramani Pokhrel, Iqbal Mahmud, Menglang Yuan, Rabi Murad, Prabin Baral, Rui Zhou, Prem Chapagain, Timothy Garrett, Stacie Stapleton, George Jallo, Chetan Bettegowda, Eric Raabe, Robert J. Wechsler-Reya, Charles G. Eberhart, Ranjan J. Perera
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-13 (2023)
Abstract Medulloblastoma (MB) develops through various genetic, epigenetic, and non-coding (nc) RNA-related mechanisms, but the roles played by ncRNAs, particularly circular RNAs (circRNAs), remain poorly defined. CircRNAs are increasingly recognized
Externí odkaz:
https://doaj.org/article/189686aa08f2466da897e79be7e129e1
Autor:
Karisa C. Schreck, Pinky Langat, Varun M. Bhave, Taibo Li, Eleanor Woodward, Christine A. Pratilas, Charles G. Eberhart, Wenya Linda Bi
Publikováno v:
npj Precision Oncology, Vol 7, Iss 1, Pp 1-11 (2023)
Abstract BRAF mutations are a significant driver of disease in pediatric low-grade glioma, but the implications of BRAF alterations on the clinical course and treatment response in adult glioma remain unclear. Here, we characterize a multi-institutio
Externí odkaz:
https://doaj.org/article/8504e89db4f34fdba7b486fa78f4849e
Autor:
Vasu Munjapara, Thatcher Heumann, Karisa C. Schreck, John M. Gross, Carlos Perez-Heydrich, Sachin K. Gujar, Charles G. Eberhart, Matthias Holdhoff
Publikováno v:
Case Reports in Oncology, Vol 15, Iss 3, Pp 909-917 (2022)
Recent advancements in understanding the biology of glioblastomas (GBM) and increasing adoption of genomic sequencing in oncology practice have led to the discovery of several targetable mutations in these cancers. Among them, the BRAF V600E mutation
Externí odkaz:
https://doaj.org/article/7eddc55ec4d04216b09735775ac98ab4
Autor:
Ashlyn Parkhurst, Sabrina Z. Wang, Tyler R. Findlay, Kristen J. Malebranche, Arman Odabas, Jesse Alt, Micah J. Maxwell, Harpreet Kaur, Cody J. Peer, William D. Figg, Katherine E. Warren, Barbara S. Slusher, Charles G. Eberhart, Eric H. Raabe, Jeffrey A. Rubens
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-14 (2022)
Abstract Atypical teratoid/rhabdoid tumors (AT/RT) are the most common malignant brain tumors of infancy and have a dismal 4-year event-free survival (EFS) of 37%. We have previously shown that mTOR activation contributes to AT/RT’s aggressive grow
Externí odkaz:
https://doaj.org/article/10b90ebb273a45c786ac0a49aa2935b6
Autor:
Bongyong Lee, Iqbal Mohamad, Rudramani Pokhrel, Rabi Murad, Menglang Yuan, Stacie Stapleton, Chetan Bettegowda, George Jallo, Charles G. Eberhart, Timothy Garrett, Ranjan J. Perera
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Medulloblastoma (MB) is the most common malignant brain tumor in children. There remains an unmet need for diagnostics to sensitively detect the disease, particularly recurrences. Cerebrospinal fluid (CSF) provides a window into the central
Externí odkaz:
https://doaj.org/article/85f890cb07c74220837525066f03f625