Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Charles G. Cochrane"'
Publikováno v:
Inflammation. 1(1)
A protein has been isolated and partially purified from the venom ofNaja naja which causes the noncytolytic release of amines from rat peritoneal mast cells. This protein, termed CVA protein, has been demonstrated to have a molecular weight of 18,500
Publikováno v:
The Journal of Immunology. 164:404-411
The fMLP-stimulated release of proinflammatory cytokines such as IL-1 by human peripheral blood monocytes is an important component of the inflammatory process. The signaling mechanisms used by fMLP to stimulate the release of cytokines are still inc
Publikováno v:
Journal of Laboratory and Clinical Medicine. 128:134-145
Publikováno v:
Pediatric Research. 39:947-952
The serum components of C-reactive protein, lysophosphatidylcholine, fibrinogen, and fibrinogen proteolytic products have been shown to reduce surface tension-lowering abilities of lung surfactant. The inhibitory effects of these serum components wer
Autor:
D Easa, Merritt Ta, M D Cunningham, Charles G. Cochrane, Mikko Hallman, D K Edwards, A Pramanik, Susan D. Revak, M S Alberts, Gregory P. Heldt
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 153:404-410
The present study was undertaken to determine if a synthetic peptide, KLLLLKLLLLKLLLLKLLLLK (KL4), in which K = lysine and L = leucine, in an aqueous dispersion of phospholipids (DPPC and POPG), would expand pulmonary alveoli and improve gas exchange
Autor:
Daniel B. Hinshaw, Klaus Vosbeck, S. Kunz, Charles G. Cochrane, Ingrid U. Scraufstatter, Paul A. Hyslop
Publikováno v:
Free Radical Biology and Medicine. 19:31-37
Host defense against bacterial pathogens in higher organisms is mediated in part by the generation of reactive oxygen species (ROS) by PMN. In this study, we determined the following effects of exposure of constant concentrations of H2O2 on E. coli i
Publikováno v:
Journal of Biological Chemistry. 270:10428-10431
Interleukin-8 (IL-8) has at least two binding regions for both the A and the B type IL-8 receptors. This study defines an important region between Cys7 and Cys50 that, together with the Glu4-Leu5-Arg6 sequence of the NH2 terminus, accounts for the hi
Autor:
B.J. Grube, Charles G. Cochrane
Publikováno v:
Journal of Biological Chemistry. 269:20791-20797
IL-6 signal transduction occurs when the liganded interleukin-6 receptor (IL-6R) interacts with glycoprotein (gp) 130. We hypothesized that synthetic peptides modeled from the extramembranous domain of the IL-6R may interfere with the IL-6-induced re
Autor:
Susan D. Revak, Charles G. Cochrane
Publikováno v:
Chest. 105:57S-62S
SP-B is the protein in pulmonary surfactant with the greatest capacity to augment the phospholipids, ability to resist surface tension, and capability to prevent collapse of pulmonary alveoli. Synthetic peptides derived from the structure of SP-B and