Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Charles G Danko"'
Publikováno v:
eLife, Vol 11 (2022)
How DNA sequence affects the dynamics and position of RNA Polymerase II (Pol II) during transcription remains poorly understood. Here, we used naturally occurring genetic variation in F1 hybrid mice to explore how DNA sequence differences affect the
Externí odkaz:
https://doaj.org/article/0d48e7764b8b4123ab81d53bbb14c3e0
Autor:
Sachi Horibata, Edward J Rice, Hui Zheng, Chinatsu Mukai, Tinyi Chu, Brooke A Marks, Scott A Coonrod, Charles G Danko
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0194522 (2018)
Discovering regulatory interactions between genes that specify the behavioral properties of cells remains an important challenge. We used the dynamics of transcriptional changes resolved by PRO-seq to identify a regulatory network responsible for end
Externí odkaz:
https://doaj.org/article/18ccffbc827744b1b08c5ada6c81555e
Autor:
Sachi Horibata, Edward J Rice, Chinatsu Mukai, Brooke A Marks, Kelly Sams, Hui Zheng, Lynne J Anguish, Scott A Coonrod, Charles G Danko
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0194023 (2018)
The RET tyrosine kinase signaling pathway is involved in the development of endocrine resistant ER+ breast cancer. However, we know little about how ER+ cells activate RET signaling and initiate an endocrine resistant phenotype. Here we show that bot
Externí odkaz:
https://doaj.org/article/f0cbcbf30bee4fb8adfff12a7990424a
Autor:
Vicki N Meyers-Wallen, Adam R Boyko, Charles G Danko, Jennifer K Grenier, Jason G Mezey, Jessica J Hayward, Laura M Shannon, Chuan Gao, Afrah Shafquat, Edward J Rice, Shashikant Pujar, Stefanie Eggers, Thomas Ohnesorg, Andrew H Sinclair
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186331 (2017)
Remarkable progress has been achieved in understanding the mechanisms controlling sex determination, yet the cause for many Disorders of Sex Development (DSD) remains unknown. Of particular interest is a rare XX DSD subtype in which individuals are n
Externí odkaz:
https://doaj.org/article/24ff92ff10bd439682ff6dbe565a1f34
Autor:
Nicholas J Fuda, Michael J Guertin, Sumeet Sharma, Charles G Danko, André L Martins, Adam Siepel, John T Lis
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005108 (2015)
Previous studies have shown that GAGA Factor (GAF) is enriched on promoters with paused RNA Polymerase II (Pol II), but its genome-wide function and mechanism of action remain largely uncharacterized. We assayed the levels of transcriptionally-engage
Externí odkaz:
https://doaj.org/article/ee4a1cac549c42cc80ed481117a2c9f7
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60465 (2013)
A bacterial transcriptome of the primary etiological agent of human dental caries, Streptococcus mutans, is described here using deep RNA sequencing. Differential expression profiles of the transcriptome in the context of carbohydrate source, and of
Externí odkaz:
https://doaj.org/article/fd7323e5ceb34df58895cba2013240ae
Autor:
Adriana K. Alexander, Edward J. Rice, Jelena Lujic, Leah E. Simon, Stephanie Tanis, Gilad Barshad, Lina Zhu, Jyoti Lama, Paula E. Cohen, Charles G. Danko
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
During spermatogenic meiosis, chromatin changes due to transcription, homologous recombination, and chromosome synapsis must be coordinated. Here they show that A-MYC and BRDT regulate release of paused RNA PolII to induce a transcriptional burst dur
Externí odkaz:
https://doaj.org/article/6364da4fd446454e9bcfa2f349fb1200
Autor:
Brooke A. Marks, Ilissa M. Pipia, Chinatsu Mukai, Sachi Horibata, Edward J. Rice, Charles G. Danko, Scott A. Coonrod
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background Rearranged during transfection (RET) tyrosine kinase signaling has been previously implicated in endocrine resistant breast cancer, however the mechanism by which this signaling cascade promotes resistance is currently not well de
Externí odkaz:
https://doaj.org/article/a513dee986ef4a7189c12bc44866baf1
Autor:
Jonathan W. Villanueva, Lawrence Kwong, Teng Han, Salvador Alonso Martinez, Michael T. Shanahan, Matt Kanke, Lukas E. Dow, Charles G. Danko, Praveen Sethupathy
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-21 (2022)
Abstract Somatic mutations drive colorectal cancer (CRC) by disrupting gene regulatory mechanisms. Distinct combinations of mutations can result in unique changes to regulatory mechanisms leading to variability in the efficacy of therapeutics. MicroR
Externí odkaz:
https://doaj.org/article/cc8338d6fe014ec1869257cb8a9ef788
Autor:
Lauren A. Choate, Gilad Barshad, Pierce W. McMahon, Iskander Said, Edward J. Rice, Paul R. Munn, James J. Lewis, Charles G. Danko
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Animal husbandry and hunting has increased human exposure to pathogens. Here, the authors investigate the evolution of human host gene expression to Bacillus anthracis infection, the bacterium that causes anthrax disease. They observe recent positive
Externí odkaz:
https://doaj.org/article/f1abda7d72c149088dee837f05360067