Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Charles F. Reich"'
Autor:
Charles F. Reich, Lisa G. Criscione-Schreiber, David S. Pisetsky, Marc Monestier, Anirudh J. Ullal, Martin Tochacek, Megan E.B. Clowse
Publikováno v:
Journal of Autoimmunity. 36:173-180
Systemic lupus erythematosus is a prototypic autoimmune disease characterized by antibodies to DNA and other nuclear molecules. While these antibodies can form immune complexes, the mechanisms generating the bound nuclear antigens are not known. Thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c8a395da3522ea8292998fecf0a218
https://doi.org/10.1016/j.jaut.2011.02.001
https://doi.org/10.1016/j.jaut.2011.02.001
Autor:
Charles F. Reich, David S. Pisetsky
Publikováno v:
Experimental Cell Research. 315:760-768
Microparticles are small membrane-bound vesicles that are released from apoptotic cells during blebbing. These particles contain DNA and RNA and display important functional activities, including immune system activation. Furthermore, nucleic acids i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af96d6e74cd5b2c18aa853fde71e3fac
https://doi.org/10.1016/j.yexcr.2008.12.014
https://doi.org/10.1016/j.yexcr.2008.12.014
Publikováno v:
Clinical Immunology. 118:209-218
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by antibodies to DNA (anti-DNA). Although these antibodies have features of antigen drive, the source of this DNA is not defined. To assess the potential role of fore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748deaa717336f0cb0bfc7dfaf8ac407
https://doi.org/10.1016/j.clim.2005.10.009
https://doi.org/10.1016/j.clim.2005.10.009
Publikováno v:
Immunology. 115:55-62
Cell death is a ubiquitous process that occurs by apoptosis or necrosis depending on the triggering event. While apoptotic and necrotic cells differ biochemically, both are cleared by macrophages for elimination. The process is very efficient, althou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec0717d8b37e07dba54c50d134a0cbc
https://doi.org/10.1111/j.1365-2567.2005.02130.x
https://doi.org/10.1111/j.1365-2567.2005.02130.x
Publikováno v:
Scandinavian Journal of Immunology. 60:159-166
DNA is a nuclear macromolecule that circulates in the blood where its levels can reflect the activity of inflammatory and malignant diseases. While dead and dying cells have usually been considered the source of blood DNA, the mechanisms for its rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb1e1093c2ba02f6d0392c9b89b9000
https://doi.org/10.1111/j.0300-9475.2004.01470.x
https://doi.org/10.1111/j.0300-9475.2004.01470.x
Publikováno v:
Blood. 102:2243-2250
After apoptosis or necrosis, macrophages clear dead cells by phagocytosis. Although this process is efficient, circulating nucleosomes can occur in certain diseases, presumably reflecting either increased production or impaired clearance. To investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b0a09fadfc035e08d77010335ec563
https://doi.org/10.1182/blood-2002-10-3312
https://doi.org/10.1182/blood-2002-10-3312
Publikováno v:
Scandinavian Journal of Immunology. 57:525-533
Antibodies to DNA (anti-DNA) play an important role in the pathogenesis of systemic lupus erythematosus (SLE). In blood, these antibodies may exist in a free, unbound state or as part of complexes with DNA. Furthermore, circulating DNA may be either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb8c0810513f78ab4c43f050e12485b
https://doi.org/10.1046/j.1365-3083.2003.01261.x
https://doi.org/10.1046/j.1365-3083.2003.01261.x
Publikováno v:
Immunology. 109:255-262
DNA, depending on base sequence, can induce a wide range of immune responses. While bacterial DNA is stimulatory, mammalian DNA is inactive alone and can, moreover, inhibit the response to bacterial DNA. To determine whether the mode of cell entry af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0700fabd1490145cfc2b36b30c8d9a4b
https://doi.org/10.1046/j.1365-2567.2003.01653.x
https://doi.org/10.1046/j.1365-2567.2003.01653.x
Publikováno v:
Clinical Immunology. 106:139-147
Nucleosomes occur in the blood of patients with systemic lupus erythematosus and are thought to result from in vivo cell death. To determine the conditions for the release of nucleosomes into the blood, normal mice were treated with four agents that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad2214186cd2122b59b89c84dddc0cc
https://doi.org/10.1016/s1521-6616(02)00027-x
https://doi.org/10.1016/s1521-6616(02)00027-x
Publikováno v:
Journal of Leukocyte Biology. 71:686-694
Synthetic 30-mer phosphorothioate (Ps) oligonucleotides (ODN) comprised of single bases (SdA30, SdC30, SdG30, and SdT30) were assessed for their effects on nitric oxide (NO) production by murine bone marrow macrophages (BMMC) and macrophage cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::011e8e21aef4cc1ec567e4e458359682
https://doi.org/10.1189/jlb.71.4.686
https://doi.org/10.1189/jlb.71.4.686