Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Charles F. Aylsworth"'
Endoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune response.
Autor:
Yasser A Aldhamen, Sergey S Seregin, David P W Rastall, Charles F Aylsworth, Yuliya Pepelyayeva, Christopher J Busuito, Sarah Godbehere-Roosa, Sungjin Kim, Andrea Amalfitano
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69539 (2013)
Endoplasmic reticulum aminopeptidase-1 (ERAP1) is a multifunctional, ubiquitously expressed enzyme whose peptide-trimming role during antigen processing for presentation by MHC I molecules is well established, however, a role for ERAP1 in modulating
Externí odkaz:
https://doaj.org/article/74cc1a3007784587abec87cfb8cf4a39
TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo.
Autor:
Sergey S Seregin, Yasser A Aldhamen, Daniel M Appledorn, Charles F Aylsworth, Sarah Godbehere, Chyong-Jy Joyce Liu, Dionisia Quiroga, Andrea Amalfitano
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22064 (2011)
Despite recent advances in developing and licensing adjuvants, there is a great need for more potent formulations to enhance immunogenicity of vaccines. An Eimeria tenella derived antigen (rEA) augments immune responses against several pathogens in a
Externí odkaz:
https://doaj.org/article/382c03f08b41402ab09ce1788a6d6372
Autor:
Efthalia Zervoudi, Yuliya Pepelyayeva, Despoina Koumantou, Yasser A. Aldhamen, Charles F. Aylsworth, Sergey S. Seregin, David P W Rastall, Dionisia Quiroga, Dimitris Georgiadis, Sarah Godbehere, Efstratios Stratikos, Andrea Amalfitano
Publikováno v:
Journal of Innate Immunity. 7:275-289
Endoplasmic reticulum aminopeptidase 1 (ERAP1) gene polymorphisms have been linked to several autoimmune diseases; however, the molecular mechanisms underlying these associations are not well understood. Recently, we demonstrated that ERAP1 regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a812722506de070ea825f6fdedd907
https://doi.org/10.1159/000368899
https://doi.org/10.1159/000368899
Autor:
Yasser A. Aldhamen, Sarah Godbehere, Andrea Amalfitano, Charles F. Aylsworth, Sergey S. Seregin
Publikováno v:
International Immunology. 26:291-303
The signaling lymphocytic activation molecule (SLAM) receptor-associated adaptor Ewing’s sarcoma-associated transcript-2 (EAT-2) is primarily expressed in innate immune cells including dendritic cells (DCs), macrophages and NK cells. A recent human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4426f0714b11870673b3c9625cd7f4d1
https://doi.org/10.1093/intimm/dxt061
https://doi.org/10.1093/intimm/dxt061
Autor:
Sarah Godbehere, Andrea Amalfitano, Charles F. Aylsworth, Sergey S. Seregin, Yasser A. Aldhamen
Publikováno v:
Human Immunology. 74:916-926
The safe and effective activation of the innate and adaptive immune systems are crucial in the implementation of immunotherapeutic modalities for the prevention and treatment of human diseases. Eimeria antigen (EA) and its recombinantly expressed ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd338630a7ec8c89571b9b5c904e5954
https://doi.org/10.1016/j.humimm.2013.04.035
https://doi.org/10.1016/j.humimm.2013.04.035
Autor:
Charles F. Aylsworth, Lynne Lippmann, Nikolay V. Dimitrov, David A. Juckett, David G. Mutch, Janet S. Rader, Matthew A. Powell
Publikováno v:
Clinical Cancer Research. 14:3089-3097
Purpose: A recombinant protein product, rBBX-01, is the first innate immunostimulator derived from a protozoan (Eimeria protozoan) and has shown potent preclinical in vivo and in vitro activities. This phase I trial was done to determine the safety a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226faff65ff885994198d6519bf6e340
https://doi.org/10.1158/1078-0432.ccr-07-4250
https://doi.org/10.1158/1078-0432.ccr-07-4250
Autor:
Sarah Godbehere-Roosa, Ram P. Kamal, Christopher F. Blum, Ian A. York, Efstratios Stratikos, Dionisia Quiroga, Andrea Amalfitano, Irini Evnouchidou, David P W Rastall, Charles F. Aylsworth, Sergey S. Seregin
Ankylosing spondylitis (AS) is a chronic systemic arthritic disease that leads to significant disability and loss of quality of life in the ∼0.5% of the worldwide human population it affects. There is currently no cure for AS and mechanisms underly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef827121e0c742f8557d914bcf44943
https://europepmc.org/articles/PMC4104477/
https://europepmc.org/articles/PMC4104477/
Autor:
John W. Judge, Min Hui Wong, Charles F. Aylsworth, Barnett Rosenberg, Peter C. Melby, Kie Hoon Jung, Brian B. Gowen, John D. Morrey
Recombinant Eimeria antigen (rEA) has been shown to have potent anticancer and antiviral activity in respective mouse disease models, presumably through robust immune stimulation that occurs via TLR11, a pattern recognition receptor that recognizes p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8dbecc5bc6f7dae965a855031118b7
https://europepmc.org/articles/PMC2517252/
https://europepmc.org/articles/PMC2517252/
Publikováno v:
Medical hypotheses. 71(1)
Colon cancer in humans results in considerable morbidity and mortality throughout most of the world. During the twentieth century, there was a rapid rise in colon cancer within modernizing countries that has not been adequately explained, although th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b933a200953901bd381cac9718136d90
https://pubmed.ncbi.nlm.nih.gov/18343044
https://pubmed.ncbi.nlm.nih.gov/18343044