Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Charles F Baer"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 13, Iss 2 (2022)
AbstractBecause of pleiotropy, mutations affect the expression and inheritance of multiple traits and, together with selection, are expected to shape standing genetic covariances between traits and eventual phenotypic divergence between populations.
Externí odkaz:
https://doaj.org/article/5df921fca866421181466221ffcd233f
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 12, Iss 5 (2022)
Abstract Caenorhabditis elegansC. elegansC. elegansUMrt ×−5 s¯
Externí odkaz:
https://doaj.org/article/d4f166ed846a44fdac9d8c64c54f7402
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0201507 (2018)
Organismal fitness is relevant in many contexts in biology. The most meaningful experimental measure of fitness is competitive fitness, when two or more entities (e.g., genotypes) are allowed to compete directly. In theory, competitive fitness is sim
Externí odkaz:
https://doaj.org/article/4773ea10496543808300e0299e779913
Autor:
Joanna Joyner-Matos, Kiley A Hicks, Dustin Cousins, Michelle Keller, Dee R Denver, Charles F Baer, Suzanne Estes
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65604 (2013)
We explored the relationship between relaxed selection, oxidative stress, and spontaneous mutation in a set of mutation-accumulation (MA) lines of the nematode Caenorhabditis elegans and in their common ancestor. We measured steady-state levels of fr
Externí odkaz:
https://doaj.org/article/e9962e8752dd42c1be968678168076aa
Publikováno v:
PLoS Genetics, Vol 6, Iss 3, p e1000877 (2010)
Genetic and developmental architecture may bias the mutationally available phenotypic spectrum. Although such asymmetries in the introduction of variation may influence possible evolutionary trajectories, we lack quantitative characterization of bias
Externí odkaz:
https://doaj.org/article/76c03d0a7662448080b788db2c2da57b
Autor:
Charles F Baer, Dee R Denver
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8750 (2010)
Biological phenotypes are described as "canalized" if they are robust to minor variation of environment and/or genetic background. The existence of a robust phenotype logically implies that some underlying mechanism must be variable, in the sense of
Externí odkaz:
https://doaj.org/article/a30f182aff404ddd947213cbdcf1f23a
Autor:
Charles F Baer
Publikováno v:
PLoS Biology, Vol 6, Iss 2, p e52 (2008)
Externí odkaz:
https://doaj.org/article/e73599b77d1a4a7182d8575c05b1fbce
Autor:
François Mallard, Luke Noble, Thiago Guzella, Bruno Afonso, Charles F. Baer, Henrique Teotónio
1AbstractWhether or not genetic divergence on the short-term of tens to hundreds of generations is compatible with phenotypic stasis remains a relatively unexplored problem. We evolved predominantly outcrossing, genetically diverse populations of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5629b510cf48dbd4db1576ea5f472d7d
https://doi.org/10.1101/2022.05.28.493856
https://doi.org/10.1101/2022.05.28.493856
Autor:
Asher D. Cutter, Charles F. Baer, Daniel E. Cook, Kimberly J. Gilbert, Erik C. Andersen, Stefan Zdraljevic
Publikováno v:
Genetics
The distribution of fitness effects (DFE) for new mutations is one of the most theoretically important but difficult to estimate properties in population genetics. A crucial challenge to inferring the DFE from natural genetic variation is the sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c93c059960f156d9593954257e25ba
C. elegans strains with the heat-sensitive mortal germline (Mrt) phenotype become progressively sterile over the course of a few tens of generations when maintained at temperatures near the upper range of C. elegans’ tolerance. Mrt is transgenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::704cef256cc29e422ef4ce2e152921f4
https://doi.org/10.1101/2021.11.29.470498
https://doi.org/10.1101/2021.11.29.470498