Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Charles Engbers"'
Autor:
Xuan Shen, Scott Jacobson, Mark S. Galinski, Rosemary Broome, Dominic Justewicz, Charles Engbers, Jonathan Liu, David E. Tabor, Xiaomu Chen, Sachin Mani
Publikováno v:
Biologicals. 41:247-253
The cold-adapted (ca) live attenuated influenza vaccine (LAIV) strains are manufactured in embryonated hens' eggs. Recently, a clonal isolate from Madin Darby Canine Kidney (MDCK) cells was derived and characterized to assess its utility as a potenti
Publikováno v:
Bioconjugate Chemistry. 18:1869-1878
New thiolytically cleavable dithiobenzyl (DTB) urethane-linked conjugates of methoxypoly(ethylene glycol) (mPEG) and a model protein, lysozyme, were prepared and thoroughly characterized. In contrast to our earlier communication [Zalipsky, et al. (19
Publikováno v:
Cancer Chemotherapy and Pharmacology. 43:1-7
Purpose: The pharmacokinetics (PK), biodistribution and therapeutic efficacy of cisplatin encapsulated in long-circulating pegylated (Stealth®) liposomes (SPI-077) were compared with those of nonliposomal cisplatin in two murine (C26 colon carcinoma
Publikováno v:
Bioconjugate Chemistry. 6:705-708
Poly(ethylene glycol) (PEG)-grafted liposomes offer new opportunities as long-circulating platforms presenting biologically relevant ligands. In pursuit of this goal, liposomal conjugates of YIGSR were prepared by mild periodate oxidation of TYIGSR-N
Publikováno v:
Bioconjugate Chemistry. 5:493-496
Lipid-conjugates of two amphipatic polymers, poly(2-methyl-2-oxazoline) (PMOZ) and poly(2-ethyl-2-oxazoline) (PEOZ) (degree of polymerization approximately 50) were synthesized by linking glutarate esters of the polymers to distearoylphosphatidyletha
Autor:
Erin Joseph, Margaret Tonda, William C. Zamboni, Dustin R. Walsh, Charles Engbers, Beth A. Zamboni, Ning Y. Yu, Sandra Strychor, Julie L. Eiseman, Robert A. Parise
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 13(23)
Purpose: S-CKD602 is a STEALTH liposomal formulation of CKD-602, a camptothecin analogue. The cytotoxicity of camptothecin analogues is related to the duration of exposure in the tumor. STEALTH liposomal formulations contain lipid conjugated to metho
Publikováno v:
Biochimica et biophysica acta. 1327(2)
Immunoliposomes composed of hydrogenated soy phosphatidylcholine, cholesterol, methoxypoly(ethylene glycol)-distearoyl phosphatidylethanolamine (mPEG-DSPE), and hydrazide-PEG-DSPE (mole ratio, 57:38:3.3:1.7) linked to periodate-oxidized chimerized mo
Autor:
Edwin Oto, Yolanda P. Quinn, Charles Engbers, Mary S. Newman, Zhu George Z, Paul S. Uster, Jan Vaage
Publikováno v:
Cancer chemotherapy and pharmacology. 39(1-2)
Poly(ethylene glycol) (PEG)-derivatized liposome vehicles improve antitumor effectiveness of entrapped anthracyclines and vinca alkaloids. However, the plasma clearance of entrapped vincristine is substantially faster than the lipid phase or other en
Publikováno v:
Endocrinology. 130(2)
A RIA for mouse growth hormone-binding protein (mGHBP) was developed. A 28-amino acid synthetic peptide corresponding to the carboxyl-terminal 27 amino acids of mGHBP plus an additional cysteine residue at the aminoterminus was coupled to keyhole lim