Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Charles E. de Bock"'
Autor:
Stien De Coninck, Renate De Smedt, Beatrice Lintermans, Lindy Reunes, Hansen J. Kosasih, Alexandra Reekmans, Lauren M. Brown, Nadine Van Roy, Bruno Palhais, Juliette Roels, Malaika Van der Linden, Jo Van Dorpe, Panagiotis Ntziachristos, Frederik W. van Delft, Marc R. Mansour, Tim Pieters, Tim Lammens, Barbara De Moerloose, Charles E. de Bock, Steven Goossens, Pieter Van Vlierberghe
Publikováno v:
Haematologica, Vol 109, Iss 5 (2023)
T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) are rare aggressive hematologic malignancies. Current treatment consists of intensive chemotherapy leading to 80% overall survival but is associated with severe tox
Externí odkaz:
https://doaj.org/article/a08f66779ce943b3bf87b6b00741dfb3
Publikováno v:
Heliyon, Vol 9, Iss 11, Pp e22085- (2023)
Mutations within the IL7-R-JAK-STAT signaling pathway are important drivers of T-cell acute lymphoblastic leukemia (T-ALL). Here we describe the important steps required to generate retroviral particles for the stable expression of mutant JAK3 constr
Externí odkaz:
https://doaj.org/article/6a03e7aa03c54534a97e5458b746fd59
Autor:
Quentin Van Thillo, Jolien De Bie, Janith A. Seneviratne, Sofie Demeyer, Sofia Omari, Anushree Balachandran, Vicki Zhai, Wai L. Tam, Bram Sweron, Ellen Geerdens, Olga Gielen, Sarah Provost, Heidi Segers, Nancy Boeckx, Glenn M. Marshall, Belamy B. Cheung, Kiyotaka Isobe, Itaru Kato, Junko Takita, Timothy G. Amos, Ira W. Deveson, Hannah McCalmont, Richard B. Lock, Ethan P. Oxley, Maximilian M. Garwood, Ross A. Dickins, Anne Uyttebroeck, Daniel R. Carter, Jan Cools, Charles E. de Bock
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
SPI1 fusion genes in T-cell acute lymphoblastic leukemia (T-ALL) are commonly found with co-occurring NRAS mutations. Here, the authors show that the combination of these oncogenes is necessary to drive T-ALL in a murine model and that the oncogenic
Externí odkaz:
https://doaj.org/article/097bfb27edca4477bb37a09172ff1f71
Autor:
Holly C.L. Pearson, Kooper V. Hunt, Toby N. Trahair, Richard B. Lock, Heather J. Lee, Charles E. de Bock
Publikováno v:
HemaSphere, Vol 6, Iss 6, p e734 (2022)
Drug resistance and treatment failure in pediatric acute lymphoblastic leukemia (ALL) are in part driven by tumor heterogeneity and clonal evolution. Although bulk tumor genomic analyses have provided some insight into these processes, single-cell se
Externí odkaz:
https://doaj.org/article/71869efe7d01412fa75e2cd2ed105ff7
Autor:
Douglas P. Mortlock, Zhi-Ming Fang, Kelly J. Chandler, Yue Hou, Lissett R. Bickford, Charles E. de Bock, Valsamma Eapen, Raymond A. Clarke
Publikováno v:
Genes, Vol 13, Iss 7, p 1195 (2022)
The human capacity to speak is fundamental to our advanced intellectual, technological and social development. Yet so very little is known regarding the evolutionary genetics of speech or its relationship with the broader aspects of evolutionary deve
Externí odkaz:
https://doaj.org/article/206133ede614427abca66ffa94bb99f2
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Cellular stress can occur in many forms; oxidative stress caused by reactive oxygen species (ROS), metabolic stress from increased metabolic programs and genotoxic stress in the form of DNA damage and disrepair. In most instances, these different typ
Externí odkaz:
https://doaj.org/article/cff0f15d7aaf4ceb896459c32960bfea
Autor:
Carmen Vicente, Rocco Stirparo, Sofie Demeyer, Charles E. de Bock, Olga Gielen, Mardelle Atkins, Jiekun Yan, Georg Halder, Bassem A. Hassan, Jan Cools
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-16 (2018)
Abstract Background The CNOT3 protein is a subunit of the CCR4-NOT complex, which is involved in mRNA degradation. We recently identified CNOT3 loss-of-function mutations in patients with T-cell acute lymphoblastic leukemia (T-ALL). Methods Here, we
Externí odkaz:
https://doaj.org/article/d2b4f3970332452b81f7d13001aa3d14
Autor:
Patrick Connerty, Ernest Moles, Charles E. de Bock, Nisitha Jayatilleke, Jenny L. Smith, Soheil Meshinchi, Chelsea Mayoh, Maria Kavallaris, Richard B. Lock
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1681 (2021)
Standard of care therapies for children with acute myeloid leukemia (AML) cause potent off-target toxicity to healthy cells, highlighting the need to develop new therapeutic approaches that are safe and specific for leukemia cells. Long non-coding RN
Externí odkaz:
https://doaj.org/article/2b83fb439aaf40ae8845b777116b0c33
Autor:
Charles E. de Bock, Michelle Down, Kinsha Baidya, Bram Sweron, Andrew W. Boyd, Mark Fiers, Gordon F. Burns, Timothy J. Molloy, Richard B. Lock, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Jan Cools, Jeff Holst, Rick F. Thorne
Publikováno v:
Haematologica, Vol 104, Iss 5 (2019)
Externí odkaz:
https://doaj.org/article/917739d4aa2b4d259a4011e995e0cec1
Autor:
Karen Verboom, Wouter Van Loocke, Pieter-Jan Volders, Bieke Decaesteker, Francisco Avila Cobos, Simon Bornschein, Charles E. de Bock, Zeynep Kalender Atak, Emmanuelle Clappier, Stein Aerts, Jan Cools, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Jo Vandesompele, Frank Speleman, Kaat Durinck
Publikováno v:
Haematologica, Vol 103, Iss 12 (2018)
Externí odkaz:
https://doaj.org/article/20376f51afbd42e3b908c9d13fd65995