Výsledky vyhledávání - "Charles E. Protzman"

Delayed Reversal of Shape Change in Cells Expressing FPB Prostanoid Receptors

Autor: John W. Regan, Charles E. Protzman, Hiromichi Fujino, Achim H.-P. Krauss, Dinesh Srinivasan, Kristen L. Pierce, David F. Woodward

Publikováno v: Journal of Biological Chemistry. 275:29907-29914

Prostaglandin F(2 alpha) (PGF(2 alpha)) receptors are G-protein-coupled receptors consisting of two alternative mRNA splice variants, named FP(A) and FP(B). As compared with the FP(A) isoform, the FP(B) isoform lacks the last 46 amino acids of the ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16578bb14eb35c5e33b5a3ab7064b41b
https://doi.org/10.1074/jbc.m003467200

Zobrazit plný text záznamu

Replacement of the carboxylic acid group of prostaglandin F2αwith a hydroxyl or methoxy substituent provides biologically unique compounds

Publikováno v: British Journal of Pharmacology. 130:1933-1943

Replacement of the carboxylic acid group of PGF(2alpha) with the non-acidic substituents hydroxyl (-OH) or methoxy (-OCH(3)) resulted in an unexpected activity profile. Although PGF(2alpha) 1-OH and PGF(2alpha) 1-OCH(3) exhibited potent contractile e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4db77a4e459e159e2b98cf72dd45616b
https://doi.org/10.1038/sj.bjp.0703462

Zobrazit plný text záznamu

Synthesis of a novel series of 3-oxo-2,4-dioxobicyclo[3.2.1]octanes: additional evidence for two thromboxane receptor subtypes

Autor: Achim H.-P. Krauss, Todd S. Gac, Robert M. Burk, Linda L. Gibson, Charles E. Protzman, David F. Woodward, Michael E. Garst

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:2103-2106

A series of 3-oxo-2,4-dioxobicyclo[3.2.1]octanes (1–4) was synthesized and identified as potent thromboxane (TXA2) receptor agonists. Replacement of the terminal -COOH group resulted in an unexpected change in biological activity: platelet aggregat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::508640486a4e724b4a9e43e6fc51a513
https://doi.org/10.1016/s0960-894x(01)80110-4

Zobrazit plný text záznamu

ChemInform Abstract: Synthesis of a Novel Series of 3-Oxo-2,4-dioxabicyclo(3.2.1)octanes: Additional Evidence for Two Thromboxane Receptor Subtypes

Autor: D.F. Woodward, Achim H.-P. Krauss, R. M. Burk, Linda L. Gibson, Todd S. Gac, M. E. Garst, Charles E. Protzman

Publikováno v: ChemInform. 26

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f1e3511f110a19afefd476db8d294e0
https://doi.org/10.1002/chin.199510289

Zobrazit plný text záznamu

Bimatoprost and prostaglandin F(2 alpha) selectively stimulate intracellular calcium signaling in different cat iris sphincter cells

Autor: David F. Woodward, Larry A. Wheeler, C.S. Spada, Achim H.-P. Krauss, Charles E. Protzman, June Chen, A.L. Nieves, David F. Scott, George Sachs

Publikováno v: Experimental eye research. 80(1)

Bimatoprost is a synthetic analog of prostaglandin F(2 alpha) ethanolamide (prostamide F(2 alpha)), and shares a pharmacological profile consistent with that of the prostamides. Like prostaglandin F(2 alpha) carboxylic acid, bimatoprost potently lowe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9479f113ebc19ad6b434b049960f4f
https://pubmed.ncbi.nlm.nih.gov/15652534

Zobrazit plný text záznamu

Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism

Autor: Filomena Fezza, T. Bisogno, Isabel Matias, V. Di Marzo, Alessia Ligresti, R. M. Burk, Yanbin Liang, Chen Li, Karen M. Kedzie, June Chen, Achim H.-P. Krauss, A.L. Nieves, Licheng Shi, David F. Woodward, L. De Petrocellis, Charles E. Protzman

Publikováno v: The Journal of pharmacology and experimental therapeutics
309 (2004): 745–757. doi:10.1124/jpet.103.061705
info:cnr-pdr/source/autori:Matias I, Chen J, De Petrocellis L, Bisogno T, Ligresti A, Fezza F, Krauss AH, Shi L, Protzman CE, Li C, Liang Y, Nieves AL, Kedzie KM, Burk RM, Di Marzo V, Woodward DF./titolo:Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism./doi:10.1124%2Fjpet.103.061705/rivista:The Journal of pharmacology and experimental therapeutics (Print)/anno:2004/pagina_da:745/pagina_a:757/intervallo_pagine:745–757/volume:309
(2004).
info:cnr-pdr/source/autori:Matias I, Chen J, De Petrocellis L, Bisogno T, Ligresti A, Fezza F, Krauss AH, Shi L, Protzman CE, Li C, Liang Y, Nieves AL, Kedzie KM, Burk RM, Di Marzo V, Woodward DF./titolo:Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism./doi:/rivista:The Journal of pharmacology and experimental therapeutics (Print)/anno:2004/pagina_da:/pagina_a:/intervallo_pagine:/volume

We investigated whether prostaglandin ethanolamides (prostamides) E(2), F(2alpha), and D(2) exert some of their effects by 1) activating prostanoid receptors either per se or after conversion into the corresponding prostaglandins; 2) interacting with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b535cc10c39bd5637d09333513bc6d7
http://www.cnr.it/prodotto/i/167314

Zobrazit plný text záznamu

Pharmacological evidence for thromboxane receptor heterogeneity--implications for the eye

Autor: Todd S. Gac, Robert M. Burk, David F. Woodward, Judith Senior, Achim H.-P. Krauss, Charles E. Protzman, Farhat Abbass, Linda L. Gibson, Kay Marshall

Publikováno v: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 13(4)

The pharmacological activity of two novel thromboxane A2 (TxA2)-mimetics, AGN191976 and AGN192093, was investigated in vitro, using standard organ bath assays and human platelets, to determine potency and selectivity at various prostanoid (PG-) recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3608e4e3bfd2d6463a8983930fbf40e7
https://pubmed.ncbi.nlm.nih.gov/9261766

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání