Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Charles E. Lyons"'
Publikováno v:
Chemical Communications. 55:5607-5610
Highly cytotoxic agents have found an important niche in targeted anticancer therapy. Here we develop a new light release strategy for the targeting of one of these agents, 2-pyrrolinodoxorubicin, showing dramatic enhancements in toxicity with light
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8292dd157b95724fe3659b8318c05218
https://doi.org/10.1039/c9cc02050k
https://doi.org/10.1039/c9cc02050k
Publikováno v:
Angewandte Chemie. 130:10420-10424
Controlled generation of cytotoxic agents with near-IR light is a current focus of photoactivated cancer therapy, including that involving cytotoxic platinum species. Herein, we present a novel heptamethine cyanine scaffolded Pt(II) complex, IR797-Pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2640e1bcda7d37cc403de7fb09ec17ca
https://doi.org/10.1002/ange.201806911
https://doi.org/10.1002/ange.201806911
Publikováno v:
FEBS Open Bio
Overproduction of cortisol by the hypothalamus–pituitary–adrenal hormone system results in the clinical disorder known as Cushing's syndrome. Genomics studies have identified a key mutation (L205R) in the α‐isoform of the catalytic subunit of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01e21f5437068fb658f94fdabb24d23
https://doi.org/10.1002/2211-5463.12396
https://doi.org/10.1002/2211-5463.12396
Publikováno v:
Virology. 516:127-138
HPV E6 oncoproteins associate with cellular PDZ proteins. In addition to previously identified cellular PDZ proteins, we found association of the HPV16 E6 PBM with the Dystrophin Glycoprotein Complex, LRCC1, and SLC9A3R2. HPV18 E6 had additional asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9048359c97745dc871ca11819b707ae
https://doi.org/10.1016/j.virol.2018.01.003
https://doi.org/10.1016/j.virol.2018.01.003
Publikováno v:
Journal of Materials Chemistry B. 6:7373-7377
Herein, we report novel hyaluronic acid formulated nanoparticles containing a platinum(II) conjugated silicon(IV) phthalocyanine (SiPc-Pt-HA) for tumor targeted red light photodynamic therapy and chemotherapy. The SiPc-Pt-HA conjugate showed specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfbbfe6a67f462947e38fe0647a11a2
https://doi.org/10.1039/c8tb02533a
https://doi.org/10.1039/c8tb02533a
Autor:
Qinglian Liu, Evans Boateng Sarbeng, Ying Yang, Charles E. Lyons, Hongtao Li, Huanyu Zhu, Lei Zhou, Qingdai Liu, Xueli Tian
Publikováno v:
J Biol Chem
Heat shock proteins of 70 kDa (Hsp70s) are ubiquitous and highly conserved molecular chaperones. They play multiple essential roles in assisting with protein folding and maintaining protein homeostasis. Their chaperone activity has been proposed to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0aa5170faac5b77e079beccbc7a7ab
https://pubmed.ncbi.nlm.nih.gov/31806707
https://pubmed.ncbi.nlm.nih.gov/31806707
Publikováno v:
Molecular Pharmacology. 90:42-51
Cytochrome P450 3A4 (CYP3A4) is the dominant P450 enzyme involved in human drug metabolism, and its inhibition may result in adverse interactions or, conversely, favorably reduce the systemic elimination rates of poorly bioavailable drugs. Herein we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebd7e23e2908b6d2db3c262e7e0daeb
https://doi.org/10.1124/mol.116.103721
https://doi.org/10.1124/mol.116.103721
Autor:
Charles E. Lyons, M. Michael Dcona, Matthew C. T. Hartman, John C. Hackett, Jonathon E. Sheldon
Publikováno v:
Organic & Biomolecular Chemistry. 14:40-49
Combretastatin A-4 (CA4) is highly potent anticancer drug that acts as an inhibitor of tubulin polymerization. The core of the CA4 structure contains a cis-stilbene, and it is known that the trans isomer is significantly less potent. We prepared an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1702d824b9b3e21dada586957dde10bb
https://doi.org/10.1039/c5ob02005k
https://doi.org/10.1039/c5ob02005k
Autor:
John C. Hackett, Charles E. Lyons, Francisco Zarate-Perez, Gareth K. Jennings, Lisa S. Shock, Jesús B. Velázquez-Fernández
Cytochrome P450 19 (CYP19, aromatase) catalyzes the conversion of androgens to estrogens in a sequence of three reactions that each depend on NADPH and O2. Aromatase is a phylogenetically-ancient enzyme and its breadth of expression in other species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f549d7e9f12d2c941f49293ed2ed15b4
https://europepmc.org/articles/PMC5964043/
https://europepmc.org/articles/PMC5964043/
Autor:
Gail E. Christie, J. Harry Caufield, Keith A. Manning, Erin A. Wall, Charles E. Lyons, Terje Dokland
Publikováno v:
Molecular Microbiology. 95:258-269
Summary Ribosomal protein L27 is a component of the eubacterial large ribosomal subunit that has been shown to play a critical role in substrate stabilization during protein synthesis. This function is mediated by the L27 N-terminus, which protrudes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ae2696cb2187089ee56bd418ffb713a
https://doi.org/10.1111/mmi.12862
https://doi.org/10.1111/mmi.12862