Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Charles E. Chase"'
Autor:
Takashi Niwa, Tsuyoshi Tahara, Charles E. Chase, Francis G. Fang, Takayoshi Nakaoka, Satsuki Irie, Emi Hayashinaka, Yasuhiro Wada, Hidefumi Mukai, Kenkichi Masutomi, Yasuyoshi Watanabe, Yilong Cui, Takamitsu Hosoya
Publikováno v:
Bulletin of the Chemical Society of Japan. 96:283-290
Autor:
Charles E. Chase, Steven Mathieu, Jing Li, Francis G. Fang, Huiming Zhang, Annie Z. Wilcoxen, Atsushi Endo, Francis Belanger
Publikováno v:
Angewandte Chemie International Edition. 54:5108-5111
Crystallization-induced diastereoselective transformation (CIDT) of an α-methyl nitrile completes an entirely non-chromatographic synthesis of the halichondrin B C14-C26 stereochemical array. The requisite α-methyl nitrile substrate is derived from
Autor:
Francis G. Fang, Charles E. Chase, Xiaojie Zhu, Matthew J. Schnaderbeck, Gordon D. Wilkie, Bryan M. Lewis
Publikováno v:
Synlett. 24:323-326
A 12-step kilogram-scale synthesis of the C1–C13 fragment, common to halichondrin B and the totally synthetic analogue Halaven® (E7389, INN eribulin mesylate), is described. The synthesis features four crystalline intermediates which facilitates t
Autor:
Yongbo Hu, James Cutter, Naoki Asai, Taichi Abe, Hyeong-Wook Choi, Teiji Takigawa, Taiju Nakamura, Thomas Noland, Masanori Mizuno, Atsushi Endo, Marc Pesant, Michael D. Lewis, Takao Omae, Bryan M. Lewis, Kazuhiro Yoshizawa, Francis G. Fang, Tomohiro Watanabe, Shawn McKenna, William J. Christ, Naoki Ozeki, Brian Austad, Gordon D. Wilkie, Hirofumi Kuroda, Trevor Lee Calkins, Manabu Kubota, Akio Kayano, Yumi Asai, John D. Orr, Matthew J. Schnaderbeck, Farid Benayoud, Yuki Komatsu, Robert Costanzo, Silvio Campagna, Taeko Suzuki, Charles E. Chase, Yuichi Kimoto
Publikováno v:
Synlett. 24:327-332
Multikilogram manufacturing process of the Halaven® C14–C35 fragment is described. The synthesis features convergent assembly of subunits by iterative asymmetric Ni/Cr-mediated coupling executed in fixed equipment.
Autor:
Hirofumi Kuroda, Huiming Zhang, Yuki Komatsu, Naoki Asakawa, Yongbo Hu, Akio Kayano, Takashi Hasebe, Takashi Kajima, Xiang Niu, Yorihisa Hoshino, Charles E. Chase, Francis G. Fang, Tomohiro Watanabe, Hiroyuki Ishizuka, Thomas Noland, Matthew J. Schnaderbeck, Thomas E. Horstmann, Naoki Asai, Mamoru Miyazawa, Katsuya Tagami, Brian Austad, Manabu Kubota, John D. Orr, Trevor Lee Calkins, Hiroyuki Chiba, Bryan M. Lewis
Publikováno v:
Synlett. 24:333-337
The evolution of the synthesis of Halaven® (E7389, INN eribulin mesylate) from a medicinal chemistry process to the execution of the final process on pilot scale is described. The completion of the synthesis of Halaven® from C1–C13 ester and C14
Autor:
Charles-André Lemelin, Boris M. Seletsky, Kimberley K. Aalfs, Paul J. Lydon, Davis Heather, Yoshito Kishi, Kathleen A. Salvato, Bruce A. Littlefield, Lynda Tremblay, Murray J. Towle, Charles E. Chase, Yongchun Shen, Lori A. Singer, Melvin J. Yu, Wanjun Zheng, Bruce F. Wels, Monica Palme
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5551-5554
Structurally simplified macrocyclic ketone analogues of halichondrin B were prepared by total synthesis and found to retain the potent cell growth inhibitory activity in vitro, stability in mouse serum, and in vivo efficacy of the natural product.
Publikováno v:
Journal of the American Chemical Society. 121:9574-9579
The first total synthesis of the cytotoxic marine metabolite agelastatin A (1) has been achieved in about 14 steps performed in 12 operations in approximately 7% overall yield starting from cyclopentadiene. Hetero Diels−Alder cycloaddition of cyclo
Autor:
Glen T. Anderson, Maoyu Shang, Steven M. Weinreb, Didier Stien, Charles E. Chase, Yung Hyo Koh
Publikováno v:
ChemInform. 30
Publikováno v:
ChemInform. 31
The first total synthesis of the cytotoxic marine metabolite agelastatin A (1) has been achieved in about 14 steps performed in 12 operations in approximately 7% overall yield starting from cyclopentadiene. Hetero Diels−Alder cycloaddition of cyclo
Autor:
Francis Belanger, Charles E. Chase, Atsushi Endo, Francis G. Fang, Jing Li, Steven R. Mathieu, Annie Z. Wilcoxen, Huiming Zhang
Publikováno v:
Angewandte Chemie International Edition. 54:4972-4972