Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Charles E Mazzucco"'
High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus.
Autor:
Michael J Wichroski, Jie Fang, Betsy J Eggers, Ronald E Rose, Charles E Mazzucco, Kevin A Pokornowski, Carl J Baldick, Monique N Anthony, Craig J Dowling, Lauren E Barber, John E Leet, Brett R Beno, Samuel W Gerritz, Michele L Agler, Mark I Cockett, Daniel J Tenney
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42609 (2012)
The recent development of a Hepatitis C virus (HCV) infectious virus cell culture model system has facilitated the development of whole-virus screening assays which can be used to interrogate the entire virus life cycle. Here, we describe the develop
Externí odkaz:
https://doaj.org/article/c696c60727114ef3a6359c336e98b64f
Autor:
Carl J Baldick, Michael J Wichroski, Annapurna Pendri, Ann W Walsh, Jie Fang, Charles E Mazzucco, Kevin A Pokornowski, Ronald E Rose, Betsy J Eggers, Mayla Hsu, Weixu Zhai, Guangzhi Zhai, Samuel W Gerritz, Michael A Poss, Nicholas A Meanwell, Mark I Cockett, Daniel J Tenney
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001086 (2010)
Small molecule inhibitors of hepatitis C virus (HCV) are being developed to complement or replace treatments with pegylated interferons and ribavirin, which have poor response rates and significant side effects. Resistance to these inhibitors emerges
Externí odkaz:
https://doaj.org/article/1ee8b0be7b894e5398d932dbcf2e4866
Autor:
Jie Fang, Carl J. Baldick, Bernadette Kienzle, Richard J. Colonno, Ann W. Walsh, Steven Levine, Charles E. Mazzucco, Kevin A. Pokornowski, Daniel J. Tenney, Ronald E. Rose, Michael Wichroski
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:2762-2772
Amino acid substitutions that confer reduced susceptibility to antivirals arise spontaneously through error-prone viral polymerases and are selected as a result of antiviral therapy. Resistance substitutions first emerge in a fraction of the circulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea3655561ff4a3203889e86ae8e0645
https://doi.org/10.1128/aac.00130-09
https://doi.org/10.1128/aac.00130-09
Autor:
Jie Fang, Ronald E. Rose, Ann W. Walsh, Steven Levine, Mayla Hsu, Joanna Yang, Betsy J. Eggers, Charles E. Mazzucco, Richard J. Colonno, Mary Jane Plym, Sharon Zhang, Carl J. Baldick, Daniel J. Tenney, Patricia Poundstone, Kevin A. Pokornowski, Cheng-Fang Yu
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:902-911
Entecavir (ETV) is a deoxyguanosine analog approved for use for the treatment of chronic infection with wild-type and lamivudine-resistant (LVDr) hepatitis B virus (HBV). In LVD-refractory patients, 1.0 mg ETV suppressed HBV DNA levels to below the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df3809379905ca949eb5306c86d4312
https://doi.org/10.1128/aac.00833-06
https://doi.org/10.1128/aac.00833-06
Autor:
Jie Fang, Mary Jane Plym, Kevin A. Pokornowski, Daniel J. Tenney, Mayla Hsu, Betsy J. Eggers, Charles E. Mazzucco, Cheng F. Yu, Sharon Zhang, Carl J. Baldick, K. Klesczewski, Ronald E. Rose, Richard J. Colonno, Ann W. Walsh, Steven Levine
Publikováno v:
Hepatology. 44:1656-1665
Comprehensive monitoring of genotypic and phenotypic antiviral resistance was performed on 673 entecavir (ETV)-treated nucleoside naïve hepatitis B virus (HBV) patients. ETV reduced HBV DNA levels to undetectable by PCR (300 copies/mL,57 IU/mL) in 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b93b3a763eae5cadf592d7076825c50
https://doi.org/10.1002/hep.21422
https://doi.org/10.1002/hep.21422
Autor:
Kin-Ray Lam, Denis R. St. Laurent, Balu Balasubramanian, Dolatrai M. Vyas, Michael H. Serrano-Wu, H. Wong, Charles E. Mazzucco, Yijun Chen, Thomas P. Tully, Terry M. Stickle, Stella Huang, James A. Matson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2757-2760
The synthesis and biological activity of sordarin oxazepine derivatives are described. The key step features a regioselective oxidation of an unprotected triol followed by double reductive amination to afford the ring-closed products. The spectrum of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d37939ab96f1503179b9da7aee68e1
https://doi.org/10.1016/s0960-894x(02)00529-2
https://doi.org/10.1016/s0960-894x(02)00529-2
Autor:
Brenda M. Ryan, Glenn Warr, Chandra S. Ramanathan, Charles E. Mazzucco, Trina C. Maurice, John W. Puziss
Publikováno v:
Yeast. 14:1105-1113
A paralog (intraspecies homolog) of the Saccharomyces cerevisiae YEF3 gene, encoding elongation factor-3, has been sequenced in the course of the yeast genome project, and identified by database searching; this gene has been designated HEF3. Bioinfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c538c57e4396602e2f165af151dd050
https://doi.org/10.1002/(sici)1097-0061(19980915)14:12<1105::aid-yea313>3.0.co
https://doi.org/10.1002/(sici)1097-0061(19980915)14:12<1105::aid-yea313>3.0.co
Autor:
Charles E. Mazzucco, Glenn Warr
Publikováno v:
Journal of Leukocyte Biology. 60:271-277
The fungal metabolite trichodimerol (BMS-182123) has demonstrated inhibition of lipopolysaccharide (LPS) -stimulated tumor necrosis factor-α (TNF-α) secretion in various in vitro macrophage models (human and murine) including primary and tumor cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be96d641f3635512a923c7d4c2986897
https://doi.org/10.1002/jlb.60.2.271
https://doi.org/10.1002/jlb.60.2.271
Autor:
Ronald E. Rose, Craig J. Dowling, Mark I. Cockett, Michael Wichroski, Lauren E. Barber, Daniel J. Tenney, Michele Agler, Samuel Gerritz, Brett R. Beno, Betsy J. Eggers, Charles E. Mazzucco, John E. Leet, Carl J. Baldick, Kevin A. Pokornowski, Monique Anthony, Jie Fang
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 8, p e42609 (2012)
PLoS ONE, Vol 7, Iss 8, p e42609 (2012)
The recent development of a Hepatitis C virus (HCV) infectious virus cell culture model system has facilitated the development of whole-virus screening assays which can be used to interrogate the entire virus life cycle. Here, we describe the develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02428d4ee430a5b86e293509ef9a40b2
http://europepmc.org/articles/PMC3412796
http://europepmc.org/articles/PMC3412796
Autor:
Charles E. Mazzucco, Terry M. Stickle, Yijun Chen, Stella Huang, Dolatrai M. Vyas, Balu Balasubramanian, Tina M. Carroll, James A. Matson, Alicia Regueiro-Ren
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3403-3405
Core-modified sordaricin derivatives were prepared via biotransformation followed by chemical modification and tested for antifungal activity. The antifungal activity proved to be very sensitive to modifications in the sterics and/or lipophilicity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d1710a1290baa2a962b10e4fd46d31
https://doi.org/10.1016/s0960-894x(02)00764-3
https://doi.org/10.1016/s0960-894x(02)00764-3