Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Charles E, Chalfant"'
Sphingolipid changes in mouse brain and plasma after mild traumatic brain injury at the acute phases
Autor:
Koushik Mondal, Nobel A. Del Mar, Ashlyn A. Gary, Richard C. Grambergs, Mohd Yousuf, Faiza Tahia, Benjamin Stephenson, Daniel J. Stephenson, Charles E. Chalfant, Anton Reiner, Nawajes Mandal
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract Background Traumatic brain injury (TBI) causes neuroinflammation and can lead to long-term neurological dysfunction, even in cases of mild TBI (mTBI). Despite the substantial burden of this disease, the management of TBI is precluded by an i
Externí odkaz:
https://doaj.org/article/290c698cee0740f99527e89df6d05ffe
Autor:
Tayleur D. White, Abdulaziz Almutairi, Ying Gai-Tusing, Daniel J. Stephenson, Benjamin D. Stephenson, Charles E. Chalfant, Xiaoyong Lei, Brian Lu, Bruce D. Hammock, Teresa P. DiLorenzo, Sasanka Ramanadham
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionWe reported that Ca2+-independent phospholipase A2β (iPLA2β)–derived lipids (iDLs) contribute to type 1 diabetes (T1D) onset. As CD4+ and CD8+ T cells are critical in promoting β-cell death, we tested the hypothesis that iDL signalin
Externí odkaz:
https://doaj.org/article/588f970bbb8d45fbb26e60d608d19390
Autor:
Curtis B. Read, Anika N. Ali, Daniel J. Stephenson, H. Patrick Macknight, Kenneth D. Maus, Chelsea L. Cockburn, Minjung Kim, Xiujie Xie, Jason A. Carlyon, Charles E. Chalfant
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTMany intracellular pathogens structurally disrupt the Golgi apparatus as an evolutionarily conserved promicrobial strategy. Yet, the host factors and signaling processes involved are often poorly understood, particularly for Anaplasma phagocy
Externí odkaz:
https://doaj.org/article/10e5f04be2dd4e119229141c954aa4ba
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-9 (2023)
Abstract Background The function of exosomes, small extracellular vesicles (sEV) secreted from human adipose-derived stem cells (ADSC), is becoming increasingly recognized as a means of transferring the regenerative power of stem cells to injured cel
Externí odkaz:
https://doaj.org/article/d9c011019d554552906ede8d66748b80
Autor:
Amy L. Lu, Li Yin, PhD, Yitao Huang, BS, Zain Husain Islam, Rohan Kanchetty, Campbell Johnston, Kaijie Zhang, MD, Xiujie Xie, PhD, Ki Ho Park, PhD, Charles E. Chalfant, PhD, Bowen Wang, PhD
Publikováno v:
JVS - Vascular Science, Vol 5, Iss , Pp 100214- (2024)
Background: Restenosis poses a significant challenge for individuals afflicted with peripheral artery diseases, often leading to considerable morbidity and necessitating repeated interventions. The primary culprit behind the pathogenesis of restenosi
Externí odkaz:
https://doaj.org/article/b2148e7a23114b61bcc2303d6ebfd0c0
Autor:
Simran Mangwani-Mordani, Amanda Prislovsky, Daniel Stephenson, Charles E. Chalfant, Anat Galor, Nawajes Mandal
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 376 (2024)
Polyunsaturated fatty acids (PUFAs) generate pro- and anti-inflammatory eicosanoids via three different metabolic pathways. This study profiled tear PUFAs and their metabolites and examined the relationships with dry eye (DE) and meibomian gland dysf
Externí odkaz:
https://doaj.org/article/6921c65a47bb4f3e9978bb7c5332f319
Autor:
Daniel J. Stephenson, H. Patrick MacKnight, L. Alexis Hoeferlin, Sonya L. Washington, Chelsea Sawyers, Kellie J. Archer, Jerome F. Strauss, III, Scott W. Walsh, Charles E. Chalfant
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 6, Pp 100377- (2023)
There are few early biomarkers to identify pregnancies at risk of preeclampsia (PE) and abnormal placental function. In this cross-sectional study, we utilized targeted ultra-performance liquid chromatography-ESI MS/MS and a linear regression model t
Externí odkaz:
https://doaj.org/article/522536cd3ef54007b913cd11e770819b
Autor:
Sandip K. Basu, Amanda Prislovsky, Nataliya Lenchik, Daniel J. Stephenson, Rajesh Agarwal, Charles E. Chalfant, Nawajes Mandal
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 742 (2024)
Vesicating chemicals like sulfur mustard (SM) or nitrogen mustard (NM) can cause devastating damage to the eyes, skin, and lungs. Eyes, being the most sensitive, have complicated pathologies that can manifest immediately after exposure (acute) and la
Externí odkaz:
https://doaj.org/article/a16aa26df15e443489aea6c7bc121596
Autor:
Kenneth D. Maus, Daniel J. Stephenson, Anika N. Ali, Henry Patrick MacKnight, Huey-Jing Huang, Jordi Serrats, Minjung Kim, Robert F. Diegelmann, Charles E. Chalfant
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 4, Pp 100187- (2022)
The sphingolipid, ceramide-1-phosphate (C1P), has been shown to promote the inflammatory phase and inhibit the proliferation and remodeling stages of wound repair via direct interaction with group IVA cytosolic phospholipase A2, a regulator of eicosa
Externí odkaz:
https://doaj.org/article/5bae0385420d4f2a836b992afeabb825
Autor:
Alexander J. Nelson, Daniel J. Stephenson, Christopher L. Cardona, Xiaoyong Lei, Abdulaziz Almutairi, Tayleur D. White, Ying G. Tusing, Margaret A. Park, Suzanne E. Barbour, Charles E. Chalfant, Sasanka Ramanadham
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 2, Pp 143-158 (2020)
Phospholipases A2 (PLA2s) catalyze hydrolysis of the sn-2 substituent from glycerophospholipids to yield a free fatty acid (i.e., arachidonic acid), which can be metabolized to pro- or anti-inflammatory eicosanoids. Macrophages modulate inflammatory
Externí odkaz:
https://doaj.org/article/6547dd63283e4d0aa77cb2128df44b45