Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Charles Ding"'
Publikováno v:
BMC Veterinary Research, Vol 20, Iss 1, Pp 1-11 (2024)
Abstract As an orally effective benzimidazole anthelmintic agent, fenbendazole was not only widely used in agriculture and animal husbandry to prevent and treat parasites, but also shows anti-cancer effects against several types of cancer, exhibits a
Externí odkaz:
https://doaj.org/article/58b5298b25814c7eb4127460e08aa4c2
Publikováno v:
Molecules, Vol 29, Iss 9, p 1915 (2024)
As a powerful imidazole antifungal drug, ketoconazole’s low solubility (0.017 mg/mL), together with its odor and irritation, limited its clinical applications. The inclusion complex of ketoconazole with randomly methylated β-cyclodextrin was prepa
Externí odkaz:
https://doaj.org/article/bac90496717347e386d8ee8246162b48
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Icariin as a hepatoprotector from Herba epimedii can expand the cardiovascular and cerebral blood vessels, promote hematopoietic functions, enhance the immune system and show anti-liver tumor activities. However, its low solubility (0.02 mg/mL) limit
Externí odkaz:
https://doaj.org/article/f6228846809b4ce29e809bd033656f73
Publikováno v:
Molecules, Vol 28, Iss 21, p 7360 (2023)
Since griseofulvin was marketed as a non-polyene antifungal antibiotic drug in 1958, its poor water solubility has been an issue for its wide applications, and over the last sixty years, many attempts have been made to increase its water solubility;
Externí odkaz:
https://doaj.org/article/ed28d14d06514dcebe58478c3be4a284
Publikováno v:
Molecules, Vol 28, Iss 21, p 7295 (2023)
Albendazole is the preferred deworming drug and has strong insecticidal effects on human and animal helminth parasites, showing remarkable activity against hepatocellular carcinoma and colorectal cancer cells. However, it is classified as being in cl
Externí odkaz:
https://doaj.org/article/70463f8c089f4dcc84e4b534f00bb1db
Autor:
Robert T Jacobs, Bakela Nare, Stephen A Wring, Matthew D Orr, Daitao Chen, Jessica M Sligar, Matthew X Jenks, Robert A Noe, Tana S Bowling, Luke T Mercer, Cindy Rewerts, Eric Gaukel, Jennifer Owens, Robin Parham, Ryan Randolph, Beth Beaudet, Cyrus J Bacchi, Nigel Yarlett, Jacob J Plattner, Yvonne Freund, Charles Ding, Tsutomu Akama, Y-K Zhang, Reto Brun, Marcel Kaiser, Ivan Scandale, Robert Don
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 5, Iss 6, p e1151 (2011)
BACKGROUND: Human African trypanosomiasis (HAT) is an important public health problem in sub-Saharan Africa, affecting hundreds of thousands of individuals. An urgent need exists for the discovery and development of new, safe, and effective drugs to
Externí odkaz:
https://doaj.org/article/63cd3700496b42e79618890a16e02bc3
Autor:
Yili, Ding, Bo, Yu, Jianzhou, Zhang, Charles, Ding, Zhiyuan, Zhang, Shufeng, Xu, Lu, Li, Hui, Yu
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 181:104-112
Tilmicosin, as an effective broad-spectrum antibacterial drug, has incomplete absorption and low bioavailability due to its low water solubility, which limits its veterinary clinical applications. As a non-polymeric drug carrier, γ-cyclodextrin was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35950734f7ef5bfccba83948bdcefaa8
https://doi.org/10.1016/j.ejpb.2022.10.024
https://doi.org/10.1016/j.ejpb.2022.10.024
Publikováno v:
Current Organic Chemistry. 27
Abstract: Transformations of the difunctionalizated cyclodextrin derivatives is a daunting task due to the challenging purification and unambiguous characterization of the final compounds. Lactose has the ability to recognize the liver cells, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5157f5ee07a8523426c0d0dd5bb881aa
https://doi.org/10.2174/1385272827666230516105952
https://doi.org/10.2174/1385272827666230516105952
Autor:
Jinping Wu, Ke An, Douglas D. Fang, Jianyu Lu, Lihong Hu, Jing Wang, Kaili Zhang, Yuanfeng Xia, Charles Ding, Shuhui Chen, Sha Wei
Publikováno v:
Cancer Research. 83:474-474
Breast cancer (BC) has recently surpassed lung cancer to become the most commonly diagnosed cancer in women worldwide. Approximately 70% of BC was ER+, in which estrogen receptor α (ERα, encoded by ESR1 gene) drives dysregulated cell proliferation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6292f778c8a957bd12423e4a282a90b4
https://doi.org/10.1158/1538-7445.am2023-474
https://doi.org/10.1158/1538-7445.am2023-474
Autor:
Xiaojiao Li, Yusi Liu, Hanxin Yao, Meng Wang, Lei Gao, Jinfeng Lou, John Mao, Wenqiang Wu, Yixin Zhou, Yanan Tang, Wenhao Yan, Yanbin Hu, Charles Ding, Shuhui Chen, Junqi Niu, Yanhua Ding
Publikováno v:
Antimicrob Agents Chemother
GST-HG131, a novel dihydroquinolizinone (DHQ) compound, has been shown to reduce circulating levels of HBsAg in animals. This first-in-human trial evaluated the safety, tolerability, and pharmacokinetic profile of GST-HG131 in healthy Chinese subject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abea040d507c96100f23c8f6577a2ea3
https://doi.org/10.1128/aac.00094-22
https://doi.org/10.1128/aac.00094-22