Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Charles David Weaver"'
Publikováno v:
Toxins, Vol 2, Iss 7, Pp 1825-1847 (2010)
The Clostridium perfringens epsilon toxin, a select agent, is responsible for a severe, often fatal enterotoxemia characterized by edema in the heart, lungs, kidney, and brain. The toxin is believed to be an oligomeric pore-forming toxin. Currently,
Externí odkaz:
https://doaj.org/article/71cc955b3b824d2fabbac42202be110d
Autor:
Charles David Weaver, Emily Days, Craig W. Lindsley, Alice L. Rodriguez, Paige N. Vinson, Colleen M. Niswender, Anna L. Blobaum, Matthew T. Loch, Caroline Anne Cuoco, P.J. Conn, Krystian A. Kozek, Mark G. Fulton
Publikováno v:
Letters in Drug Design & Discovery
Background: This article describes the challenges in the discovery and optimization of mGlu2/4 heterodimer Positive Allosteric Modulators (PAMs). Methods: Initial forays based on VU0155041, a PAM of both the mGlu4 homodimer and the mGlu2/4 heterodime
Autor:
John Scott Daniels, Allison Anderson, Corey R. Hopkins, Ezequiel Marron Fernandez de Velasco, Ryan D. Morrison, Kristopher K. Abney, Baovi N. Vo, Michael A. Benneyworth, Charles David Weaver, Kevin Wickman
Publikováno v:
British Journal of Pharmacology.
Background and purpose G protein-gated inwardly rectifying K+ (Kir 3) channels moderate the activity of excitable cells and have been implicated in neurological disorders and cardiac arrhythmias. Most neuronal Kir 3 channels consist of Kir 3.1 and Ki
Autor:
Baovi N, Vo, Kristopher K, Abney, Allison, Anderson, Ezequiel, Marron Fernandez de Velasco, Michael A, Benneyworth, John Scott, Daniels, Ryan D, Morrison, Corey R, Hopkins, Charles David, Weaver, Kevin, Wickman
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: G protein‐gated inwardly rectifying K(+) (K(ir)3) channels moderate the activity of excitable cells and have been implicated in neurological disorders and cardiac arrhythmias. Most neuronal K(ir)3 channels consist of K(ir)3.
Autor:
J.T. Manka, H. Lavreysen, Colleen M. Niswender, A. Ahnaou, Shaun R. Stauffer, Carrie K. Jones, Marc G. Caron, Tanya L. Daigle, Thomas M. Bridges, B.J. Hrupka, E.J. Herman, Charles David Weaver, Wilhelmus Drinkenburg, Amy J. Ramsey, A.S. Hammond, Gregor James Macdonald, Claire Mackie, Thomas Steckler, Satyawan Jadhav, Craig W. Lindsley, Karen J. Gregory, José M. Bartolomé, P.J. Conn, Nellie Byun
Impaired transmission through glutamatergic circuits has been postulated to play a role in the underlying pathophysiology of schizophrenia. Furthermore, inhibition of the N-methyl-d-aspartate (NMDA) subtype of ionotropic glutamate receptors (NMDAR) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1113d19bcf1590aba878570cad029dbc
https://europepmc.org/articles/PMC3807069/
https://europepmc.org/articles/PMC3807069/
Autor:
Richard Williams, Kari A. Johnson, Patrick R. Gentry, Craig W. Lindsley, P. Jeffrey Conn, Corey R. Hopkins, Colleen M. Niswender, Charles David Weaver
Publikováno v:
ChemInform. 41
This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis ap
Autor:
Craig W. Lindsley, Richard Williams, Kari A. Johnson, Colleen M. Niswender, P. Jeffrey Conn, Corey R. Hopkins, Patrick R. Gentry, Charles David Weaver
This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80334d235a2b4088df721f8c2e8e2e1c
https://europepmc.org/articles/PMC2752865/
https://europepmc.org/articles/PMC2752865/
Autor:
Mathew M. Mock, Fang Zheng, Colleen M. Niswender, Satyawan Jadhav, Richard Williams, P. Jeffrey Conn, Nellie Byun, Carrie K. Jones, Alexander S. Kane, Douglas J. Sheffler, L. Michelle Lewis, Zixiu Xiang, Charles David Weaver, Craig W. Lindsley, Thomas M. Bridges
Previous studies suggest that selective antagonists of specific subtypes of muscarinic acetylcholine receptors (mAChRs) may provide a novel approach for the treatment of certain central nervous system (CNS) disorders, including epileptic disorders, P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd342801f70a54fb844438f0bdf91137
https://europepmc.org/articles/PMC2713127/
https://europepmc.org/articles/PMC2713127/
Autor:
Thomas M. Bridges, Lyndsey Williams, L. Michelle Lewis, Richard Williams, Colleen M. Niswender, J. Phillip Kennedy, Craig W. Lindsley, Natalia T. Nalywajko, Matthew J. Mulder, P. Jeffrey Conn, John T. Brogan, Charles David Weaver, Douglas J. Sheffler
This Letter describes the synthesis and SAR, developed through an iterative analogue library approach, of a novel series of selective M1 mAChR antagonists for the potential treatment of Parkinson's disease, dystonia and other movement disorders. Comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7551f8836883387c249a775ab62ad116
https://europepmc.org/articles/PMC2275053/
https://europepmc.org/articles/PMC2275053/
Autor:
S. Zhou, Satyawan Jadhav, Corey R. Hopkins, Rocco D. Gogliotti, Kari A. Johnson, C.K. Jones, Craig W. Lindsley, P.J. Conn, Darren W. Engers, Charles David Weaver, Usha N. Menon, Richard A Williams, Colleen M. Niswender, Analisa D. Thompson, Y.-Y. Cheung, James M. Salovich, Patrick R. Gentry, Emily Days, Rocio Zamorano
Publikováno v:
Parkinsonism & Related Disorders. 15:S117