Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Charles D. Meyers"'
Autor:
Srikanth Neelakantham, Ronenn Roubenoff, Tania Garito, Daniel Rooks, Linda Morrow, Charles D. Meyers, Olivier Petricoul, Lee Anne Filosa, Katherine Gomez, Marcus Hompesch, Marjorie Zakaria, Monte S. Buchsbaum, Therese Swan, Didier Laurent
Publikováno v:
Diabetes, Obesity and Metabolism. 20:94-102
Background Skeletal muscle is a key mediator of insulin resistance. Bimagrumab, an antibody against activin receptor type II (ActRII), prevents binding of negative muscle regulators, like myostatin, and increases lean mass and decreases fat mass in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c77d2496f8c9f387521d5a9d92801b3
https://doi.org/10.1111/dom.13042
https://doi.org/10.1111/dom.13042
Autor:
Kiran Dole, Brigitte Wiedmann, Jin Chen, Edward Gane, Charles D. Meyers, Prakash Raman, Richard Colvin, Jin Zhang, Catherine A.M. Stedman
Publikováno v:
ACS Infectious Diseases. 3:144-151
Hepatitis C virus (HCV) infection is a significant cause of liver disease affecting 80-150 million people globally. Diacylglycerol transferase 1 (DGAT-1), a triglyceride synthesis enzyme, is important for the HCV life cycle in vitro. Pradigastat, a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a4b17815da71ed543995560fcd6424
https://doi.org/10.1021/acsinfecdis.6b00138
https://doi.org/10.1021/acsinfecdis.6b00138
Autor:
Srikanth Neelakantham, Tapan K. Majumdar, Aishwarya Movva, Atish Salunke, Charles D. Meyers, Kenneth Kulmatycki, Anne Crissey, Jin Chen, Adele Noe
Publikováno v:
Clinical Pharmacology in Drug Development. 5:450-459
Pradigastat, a novel diacylglycerol acyltransferase 1 inhibitor, has been studied in familial chylomicronemia syndrome. To evaluate the effects of supratherapeutic concentrations of pradigastat on the QTc interval, 2 studies were conducted. The first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cbbad0fd4abf66631d02bf64754252
https://doi.org/10.1002/cpdd.278
https://doi.org/10.1002/cpdd.278
Autor:
Yan-Ling He, Shenglin Ma, Anisha E. Mendonza, Ping Mahling, William Haynes, Charles D. Meyers, Yiming Zhang, Ahmed Amer, Eric Bachman, William A. Chutkow
Publikováno v:
Diabetes, obesitymetabolism. 21(6)
BACKGROUND There is an unmet need for a safer and more effective treatment for obesity. This study assessed the effects of licogliflozin, a dual inhibitor of sodium-glucose co-transporter (SGLT) 1/2, on body weight, metabolic parameters and incretin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1511810a638f06a146b9cddc1ae6c251
https://pubmed.ncbi.nlm.nih.gov/30724002
https://pubmed.ncbi.nlm.nih.gov/30724002
Autor:
Ping Mahling, Shenglin Ma, Anisha E. Mendonza, William G. Haynes, Yiming Zhang, Yan-Ling He, Ahmed Amer, William A. Chutkow, Eric Bachman, Charles D. Meyers
Publikováno v:
Diabetes. 67
Background: LIK066 is a potent dual inhibitor of SGLT1/2 (IC50: 20.6 and 0.58 nM for SGLT1 and SGLT2). We studied mechanistic effects of dual SGLT1/2 inhibition of SGLT1 in the gut and SGLT1/2 in the kidneys. Methods: Effects of LIK066 on weight, glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bf3063e3b25d514515c09e871a28121
https://doi.org/10.2337/db18-114-lb
https://doi.org/10.2337/db18-114-lb
Autor:
Parasar Pal, Ralph Matott, Sam Rebello, Surya Ayalasomayajula, Gangadhar Sunkara, Tapan Majumdar, Anne Crissey, Charles D. Meyers, Jing Yu, Jin Chen, Zhenzhong Su, Mark Kagan
Publikováno v:
Biopharmaceutics & Drug Disposition. 36:452-461
Pradigastat, a diacylglycerol acyltransferase 1 inhibitor, is being developed for the treatment of familial chylomicronemia syndrome. The results of two studies that evaluated the effect of food on the oral bioavailability of pradigastat using random
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::911a5f8b5f732e031a5479f311d9a1ff
https://doi.org/10.1002/bdd.1958
https://doi.org/10.1002/bdd.1958
Autor:
Michael H. Serrano-Wu, Alan D. Neubert, Katsumasa Nakajima, Jingzhou Li, Qing Yang, David Truong, Kevin B. Clairmont, Renee Commerford, Aaron Kanter, Thomas Daniels, Young-Shin Kwak, Paul V. Szklennik, Yongjin Gong, Vivienne Tedesco, Gary M. Coppola, Brian K. Hubbard, Ricardo E. Chatelain, Thomas A. Gilmore, Charles D. Meyers, Forster Cornelia J, Monish Jain, James Thompson
Publikováno v:
Journal of medicinal chemistry. 60(11)
Modification of a gut restricted class of benzimidazole DGAT1 inhibitor 1 led to 9 with good oral bioavailability. The key structural changes to 1 include bioisosteric replacement of the amide with oxadiazole and α,α-dimethylation of the carboxylic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa6137e12579f36a972ee08d1ca7bc6
https://pubmed.ncbi.nlm.nih.gov/28498655
https://pubmed.ncbi.nlm.nih.gov/28498655
Autor:
Elyse Swallow, Diane Brisson, James Signorovitch, Daniel Gaudet, Liangyi Fan, Charles D. Meyers, Jean-Bernard Gruenberger, Karine Tremblay
Publikováno v:
Journal of Medical Economics. 16:657-666
The prevalence of severe hypertriglyceridemia (TG 1000 mg/dl) is estimated at 150-400 per 100,000 individuals in North America. Severe hypertriglyceridemia in the fasting state is associated with increased acute pancreatitis risk and is a sign of chy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd47a53b844cb65abddf73145b3de08d
https://doi.org/10.3111/13696998.2013.779277
https://doi.org/10.3111/13696998.2013.779277
Autor:
Kenneth Kulmatycki, Angela Bretz, Melissa Lin, Charles D. Meyers, Tapan K. Majumdar, Lana Peng, Alana Upthagrove, Phi Tran, Jin Chen, Lai Wang, Safet Palamar, Heidi J. Einolf
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 47(12)
1. Pradigastat is a potent and specific diacylglycerol acyltransferase-1 (DGAT1) inhibitor effective in lowering postprandial triglycerides (TG) in healthy human subjects and fasting TG in familial chylomicronemia syndrome (FCS) patients. 2. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aadaed0289d36bc9328e063d49d3cc25
https://pubmed.ncbi.nlm.nih.gov/27855567
https://pubmed.ncbi.nlm.nih.gov/27855567
Autor:
Srikanth Neelakantham, Craig Trusley, Charles D. Meyers, Tapan K. Majumdar, Suraj Bhansali, Sam Rebello, Gangadhar Sunkara, Jin Chen
Publikováno v:
International journal of clinical pharmacology and therapeutics. 53(4)
Objective: We evaluated the potential pharmacokinetic interaction between pradigastat a potent and selective diacylglycerol acyltransferase 1 inhibitor and Levora-28(R) a combination oral contraceptive (COC) containing 30 mug ethinylestradiol (EE) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e943e713aee825c0a342bcf127db5a9
https://pubmed.ncbi.nlm.nih.gov/25740268
https://pubmed.ncbi.nlm.nih.gov/25740268