Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Charles D. Malis"'
Publikováno v:
American Journal of Physiology-Renal Physiology. 245:F735-F742
This study was designed to determine whether verapamil protects renal function in experimental ischemia in the rat and, if so, whether the protection is mediated by verapamil's vasodilatory action or by an effect on renal cells independent of vascula
Autor:
Charles D. Malis, Joseph V. Bonventre
Publikováno v:
Journal of Biological Chemistry. 261:14201-14208
With a variety of forms of ischemic and toxic tissue injury, cellular accumulation of Ca2+ and generation of oxygen free radicals may have adverse effects upon cellular and, in particular, mitochondrial membranes. Damage to mitochondria, resulting in
Publikováno v:
New England Journal of Medicine. 314:1670-1676
ISCHEMIC diseases of the heart, kidney, and brain continue to be the primary causes of mortality and morbidity in the United States and other Western industrialized nations. The magnitude of the problem has stimulated much research directed at identi
Publikováno v:
Proceedings of the National Academy of Sciences. 78:5528-5532
Synthetic 3-phosphocitrate, an extremely potent inhibitor of calcium phosphate crystallization as determined in a nonbiological physical-chemical assay, has many similarities to a mitochondrial factor that inhibits crystallization of nondiffracting a
Publikováno v:
Analytical biochemistry. 112(2)
A simple method of extracting calcium from kidney tissue prior to atomic absorption measurements of calcium in experimental models of nephrocalcinosis is described. This technique results in substantial time savings over traditional ashing or acid-di