Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Charles D. Hébert"'
Autor:
Víctor A. Arrieta, Craig Horbinski, Rimas V. Lukas, Jawad Fares, Maciej S. Lesniak, Theresa V. Strong, Karen S. Aboody, Jana Portnow, Sean Grimm, David T. Curiel, Hui Zhang, Catalina Lee-Chang, Roger Stupp, Christina Amidei, Ann K. Adams, James P. Chandler, Priya Kumthekar, Matthew C. Tate, Sean Sachdev, Ilya V. Ulasov, Markella Zannikou, Atique Ahmed, Kirsten Bell Burdett, Adam M. Sonabend, Charles D. Hébert, Irina V. Balyasnikova, Jason Miska
Publikováno v:
The Lancet. Oncology. 22(8)
Summary Background Malignant glioma is the most common and lethal primary brain tumour, with dismal survival rates and no effective treatment. We examined the safety and activity of NSC-CRAd-S-pk7, an engineered oncolytic adenovirus delivered by neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f8d4c4ff863559536e1376cbb7b9a3
https://pubmed.ncbi.nlm.nih.gov/34214494
https://pubmed.ncbi.nlm.nih.gov/34214494
Autor:
Johnathan Furr, B Collins, Keith R. Shockley, Helen Cunny, Charles D. Hébert, AtLee T. D. Watson, Lori Smith, Lutfiya Miller-Pinsler, Kristin Aillon, Vicki Sutherland, Guanhua Xie, Trey Vinke, Suramya Waidyanatha, Barry S. McIntyre
Publikováno v:
Toxicol Sci
Human exposure to boron occurs primarily through diet and drinking water sources. Animal studies have found that reduced fetal weight following gestational exposure to boron (as boric acid) is the most sensitive toxicological effect. However, recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15eb29ab3dec1006a18db17f44373153
https://europepmc.org/articles/PMC7357175/
https://europepmc.org/articles/PMC7357175/
Autor:
Jason J. Rose, Sheila D. Grimes, James S. Toomey, Lutfiya Miller, Rakesh P. Patel, Charles D. Hébert, Joo-Yeun Oh
Publikováno v:
Toxicol Appl Pharmacol
Intramuscular (IM) injection of nitrite (1-10 mg/kg) confers survival benefit and protects against lung injury after exposure to chlorine gas in preclinical models. Herein, we evaluated safety/toxicity parameters after single, and repeated (once dail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde24a0643fb86fb2914729588e64c5b
https://doi.org/10.1016/j.taap.2021.115702
https://doi.org/10.1016/j.taap.2021.115702
Publikováno v:
Virology. 500
For the development of a human West Nile (WN) infectious DNA (iDNA) vaccine, we created highly attenuated chimeric virus W1806 with the serological identity of highly virulent WN-NY99. Earlier, we attempted to utilize mutations found in the E protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa449f914ec7a9c63a14ed72600a00c
https://pubmed.ncbi.nlm.nih.gov/27816638
https://pubmed.ncbi.nlm.nih.gov/27816638
Autor:
Atique U. Ahmed, Lingjiao Zhang, Charles D. Hébert, Jian Qiao, Drew A. Spencer, Joshua Robert Kane, Brenda Auffinger, Alan L. Chang, Maciej S. Lesniak, Meijing Wu, Karen S. Aboody, Jacob S. Young, Theresa V. Strong, Jill F. Mann, Deepak Kanojia, Julius W. Kim, Jason Miska
Publikováno v:
Journal of Translational Medicine
Background CRAd-S-pk7 is a conditionally replicative oncolytic adenoviral vector that contains a survivin promoter and a pk7 fiber modification that confer tumor-specific transcriptional targeting and preferential replication in glioma while sparing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc3e9a12152a8bee546ae9255ed54a1
https://doi.org/10.1186/s12967-016-0895-8
https://doi.org/10.1186/s12967-016-0895-8
Autor:
Charles D. Hébert, J. Gregory Hixon, Deborah M. Proctor, Howard G. Shertzer, Chad M. Thompson, Mina Suh, Mark A. Harris, Jill F. Mann, Laurie C. Haws
Publikováno v:
Toxicological Sciences
Exposure to high concentrations of hexavalent chromium (Cr[VI]) in drinking water is reported to induce oral mucosa tumors in F344 rats and intestinal tumors in B6C3F1 mice. To investigate the modes of action underlying these tumors, 90-day drinking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e2969f4105c66ef99f8855276a973a
https://doi.org/10.1093/toxsci/kfr280
https://doi.org/10.1093/toxsci/kfr280
Autor:
Chad M. Thompson, Charles D. Hébert, Timothy R. Zacharewski, J. Gregory Hixon, Deborah M. Proctor, Howard G. Shertzer, Mark A. Harris, Laurie C. Haws, Sheila D. Grimes, Anna K. Kopec
Publikováno v:
Toxicological Sciences. 123:58-70
Chronic ingestion of high concentrations of hexavalent chromium [Cr(VI)] in drinking water induces intestinal tumors in mice. To investigate the mode of action (MOA) underlying these tumors, a 90-day drinking water study was conducted using similar e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa62a413701f21778bee547da5ea5f7
https://doi.org/10.1093/toxsci/kfr164
https://doi.org/10.1093/toxsci/kfr164
Autor:
Barry S. McIntyre, Suramya Waidyanatha, L. Earl Gray, Jui-Hua Hsieh, Paul M. D. Foster, Justin M. Conley, K. J. Turner, Minerva Mercado-Felciano, Vicki Sutherland, Helen C. Cunny, Charles D. Hébert, Johnathan Furr
Publikováno v:
Reproductive Toxicology. 80:32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69848223b5a26e859453717c75465dba
https://doi.org/10.1016/j.reprotox.2018.06.066
https://doi.org/10.1016/j.reprotox.2018.06.066
Autor:
Charles D. Hébert, Douglas W. Bristol, Rajendra S. Chhabra, John C. Peckham, Scott S. Auerbach, Gregory S. Travlos
Publikováno v:
Food and Chemical Toxicology. 48:169-177
Methylene blue trihydrate has a variety of biomedical and biologically therapeutic applications. Groups of 50 male and 50 female rats and mice were administered methylene blue trihydrate in 0.5% aqueous methylcellulose solution by gavage at doses of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f7ddafe84c494ed36e4526703b7972
https://doi.org/10.1016/j.fct.2009.09.034
https://doi.org/10.1016/j.fct.2009.09.034
Publikováno v:
Toxicology and Applied Pharmacology. 211:115-123
Indole-3-carbinol (I-3-C) and 3,3'-diindolylmethane (DIM) have been shown to reduce the incidence and multiplicity of cancers in laboratory animal models. Based on the observation that I-3-C induced hepatocyte hypertrophy when administered orally for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54f99911ee999c91a6148513cdacbee
https://doi.org/10.1016/j.taap.2005.06.011
https://doi.org/10.1016/j.taap.2005.06.011