Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Charles D. Conover"'
Publikováno v:
Artificial Organs. 21:907-915
This study compares the effects of polyethylene glycol (PEG) modified bovine hemoglobin on vascular half-life and renal function in rabbits to those of unmodified bovine hemoglobin. Renal function was assessed by the measurement of the glomerular fil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf08fa42270ce1d300cffa3455f78c9
https://doi.org/10.1111/j.1525-1594.1997.tb00250.x
https://doi.org/10.1111/j.1525-1594.1997.tb00250.x
Autor:
Jing Xia, Clifford Longley, Yun H. Choe, Charles D. Conover, Qiuxia Zhao, Shuiyun Guan, Richard B. Greenwald, Hong Zhao
Publikováno v:
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics. 14:455-468
6-Mercaptopurine (6-MP) is an orally administered, water-insoluble purine analog that is effective against acute lymphatic leukemia. Oral absorption of 6-MP, however, is quite erratic, with only 16-50% of the administered dose reaching the blood. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e767024f29b977de5f73e17d0962657
https://doi.org/10.3727/0965040041791446
https://doi.org/10.3727/0965040041791446
Publikováno v:
Bioconjugate Chemistry. 14:661-666
This paper reports on the synthesis, safety, and efficacy of a series of water-soluble derivatives of poly(ethylene glycol) (PEG)-conjugated amphotericin B (AmB). PEG 40 000 attached to the sugar amino group of AmB via labile carbamate and carbonate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59774e3a9da645781d0cdfb861db18ac
https://doi.org/10.1021/bc0256594
https://doi.org/10.1021/bc0256594
Publikováno v:
Advanced Drug Delivery Reviews. 55:217-250
The current review presents an update of drug delivery using poly(ethylene glycol) (PEG), that focuses on recent developments in both protein and organic drugs. Certainly the past 10 years has resulted in a renaissance of the field of PEG drug conjug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3356a6984ea905f699ab468c5794378
https://doi.org/10.1016/s0169-409x(02)00180-1
https://doi.org/10.1016/s0169-409x(02)00180-1
Autor:
Yun H. Choe, Dechun Wu, Yoany Gervacio, Charles D. Conover, Maksim Royzen, Virna Borowski, Richard B. Greenwald, Mary Mehlig
Publikováno v:
Journal of Controlled Release. 79:55-70
The synthesis of branched PEG (40,000) acids has been achieved using aspartic acid (Asp) and AspAsp dendrons. Complete conjugation of these dendritic acids with cytosine arabinoside (ara-C) was achieved by the use of spacers that allowed a greater se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49df770d37645544a5c1b3047850b55
https://doi.org/10.1016/s0168-3659(01)00470-9
https://doi.org/10.1016/s0168-3659(01)00470-9
Autor:
Richard B. Greenwald, Maksim Royzen, Charles D. Conover, Dechun Wu, Yun H. Choe, Kwok L. Shum
Publikováno v:
Journal of Medicinal Chemistry. 43:475-487
A novel methodology for the synthesis of poly(ethylene glycol) (PEG) prodrugs of amino-containing compounds has been developed which is based on the trimethyl lock lactonization reaction. These PEG-modified double prodrugs are water soluble, and by s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb83b8989587e77ef033fa0e644a5eb3
https://doi.org/10.1021/jm990498j
https://doi.org/10.1021/jm990498j
Publikováno v:
Bioconjugate Chemistry. 10:973-981
The utility of single-chain Fv proteins as therapeutic agents would be substantially broadened if the circulating lives of these minimal antigen-binding polypeptides were both prolonged and adjustable. Poly(ethylene glycol) (PEG) bioconjugate derivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3450edf57b7ea79a2314f9a2900d83
https://doi.org/10.1021/bc990076o
https://doi.org/10.1021/bc990076o
Autor:
Yun H. Choe, Richard B. Greenwald, Charles D. Conover, Anthony Martinez, Shuiyun Guan, Annapurna Pendri, Dechun Wu, Kwok L. Shum, Zuliang Yao
Publikováno v:
Journal of Controlled Release. 61:281-294
This paper reports on the synthesis and in vivo oncolytic activity of a series of water-soluble acyl derivatives of polyethylene glycol (PEG) conjugated podophyllotoxin. Some analogs of the polymer conjugate showed significantly better activity in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3953ddfc722786c5014a4faf472a2460
https://doi.org/10.1016/s0168-3659(99)00153-4
https://doi.org/10.1016/s0168-3659(99)00153-4
Autor:
Charles D. Conover, Anthony Martinez, Richard B. Greenwald, Hong Zhao, Annapurna Pendri, Shuiyun Guan, Yun H. Choe, Kwok L. Shum
Publikováno v:
Journal of Medicinal Chemistry. 42:3657-3667
A general methodology for synthesizing poly(ethylene glycol) (PEG) prodrugs of amino-containing compounds has been developed and constitutes the basis for solubilization of insoluble drugs, extending plasma circulating half-lives and, in the case of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c42bb5513b40564bbc90fe62227a38
https://doi.org/10.1021/jm990166e
https://doi.org/10.1021/jm990166e
Publikováno v:
Cancer Chemotherapy and Pharmacology. 42:407-414
Purpose: This study was designed to assess the circulatory retention, antitumor activity and tissue biodistribution of polyethylene glycol (PEG)-conjugated camptothecin-20-O-glycinate, PEG-β-camptothecin (PEG-β-CPT). PEG-β-CPT is a novel water-sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a468f91670057948f145a3827ca1fa9
https://doi.org/10.1007/s002800050837
https://doi.org/10.1007/s002800050837