Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Charles D Stiles"'
Autor:
Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim
Publikováno v:
eLife, Vol 6 (2017)
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context
Externí odkaz:
https://doaj.org/article/8eec2bdf4b584beabb46e378e18f1d59
Autor:
Patricia L M Dahia, Ken N Ross, Matthew E Wright, César Y Hayashida, Sandro Santagata, Marta Barontini, Andrew L Kung, Gabriela Sanso, James F Powers, Arthur S Tischler, Richard Hodin, Shannon Heitritter, Francis Moore, Robert Dluhy, Julie Ann Sosa, I Tolgay Ocal, Diana E Benn, Deborah J Marsh, Bruce G Robinson, Katherine Schneider, Judy Garber, Seth M Arum, Márta Korbonits, Ashley Grossman, Pascal Pigny, Sérgio P A Toledo, Vania Nosé, Cheng Li, Charles D Stiles
Publikováno v:
PLoS Genetics, Vol 1, Iss 1, Pp 72-80 (2005)
Pheochromocytomas are neural crest-derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct functions. We show here a functional link between tumo
Externí odkaz:
https://doaj.org/article/7bb7eecfd11145148cad35a3854632b4
Autor:
Laura E MacConaill, Catarina D Campbell, Sarah M Kehoe, Adam J Bass, Charles Hatton, Lili Niu, Matt Davis, Keluo Yao, Megan Hanna, Chandrani Mondal, Lauren Luongo, Caroline M Emery, Alissa C Baker, Juliet Philips, Deborah J Goff, Michelangelo Fiorentino, Mark A Rubin, Kornelia Polyak, Jennifer Chan, Yuexiang Wang, Jonathan A Fletcher, Sandro Santagata, Gianni Corso, Franco Roviello, Ramesh Shivdasani, Mark W Kieran, Keith L Ligon, Charles D Stiles, William C Hahn, Matthew L Meyerson, Levi A Garraway
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7887 (2009)
Detection of critical cancer gene mutations in clinical tumor specimens may predict patient outcomes and inform treatment options; however, high-throughput mutation profiling remains underdeveloped as a diagnostic approach. We report the implementati
Externí odkaz:
https://doaj.org/article/388609211758433580e680225740cbc3
Autor:
Eshini Panditharatna, Joana G. Marques, Tingjian Wang, Maria C. Trissal, Ilon Liu, Li Jiang, Alexander Beck, Andrew Groves, Neekesh V. Dharia, Deyao Li, Samantha E. Hoffman, Guillaume Kugener, McKenzie L. Shaw, Hafsa M. Mire, Olivia A. Hack, Joshua M. Dempster, Caleb Lareau, Lingling Dai, Logan H. Sigua, Michael A. Quezada, Ann-Catherine J. Stanton, Meghan Wyatt, Zohra Kalani, Amy Goodale, Francisca Vazquez, Federica Piccioni, John G. Doench, David E. Root, Jamie N. Anastas, Kristen L. Jones, Amy Saur Conway, Sylwia Stopka, Michael S. Regan, Yu Liang, Hyuk-Soo Seo, Kijun Song, Puspalata Bashyal, William P. Jerome, Nathan D. Mathewson, Sirano Dhe-Paganon, Mario L. Suvà, Angel M. Carcaboso, Cinzia Lavarino, Jaume Mora, Quang-De Nguyen, Keith L. Ligon, Yang Shi, Sameer Agnihotri, Nathalie Y.R. Agar, Kimberly Stegmaier, Charles D. Stiles, Michelle Monje, Todd R. Golub, Jun Qi, Mariella G. Filbin
Publikováno v:
Cancer Discovery. :OF1-OF26
Diffuse midline gliomas are uniformly fatal pediatric central nervous system cancers that are refractory to standard-of-care therapeutic modalities. The primary genetic drivers are a set of recurrent amino acid substitutions in genes encoding histone
Autor:
Mariella G. Filbin, Jun Qi, Todd R. Golub, Michelle Monje, Charles D. Stiles, Kimberly Stegmaier, Nathalie Y.R. Agar, Sameer Agnihotri, Yang Shi, Keith L. Ligon, Quang-De Nguyen, Jaume Mora, Cinzia Lavarino, Angel M. Carcaboso, Mario L. Suvà, Sirano Dhe-Paganon, Nathan D. Mathewson, William P. Jerome, Puspalata Bashyal, Kijun Song, Hyuk-Soo Seo, Yu Liang, Michael S. Regan, Sylwia Stopka, Amy Saur Conway, Kristen L. Jones, Jamie N. Anastas, David E. Root, John G. Doench, Federica Piccioni, Francisca Vazquez, Amy Goodale, Zohra Kalani, Meghan Wyatt, Ann-Catherine J. Stanton, Michael A. Quezada, Logan H. Sigua, Lingling Dai, Caleb Lareau, Joshua M. Dempster, Olivia A. Hack, Hafsa M. Mire, McKenzie L. Shaw, Guillaume Kugener, Samantha E. Hoffman, Deyao Li, Neekesh V. Dharia, Andrew Groves, Alexander Beck, Li Jiang, Ilon Liu, Maria C. Trissal, Tingjian Wang, Joana G. Marques, Eshini Panditharatna
Supplementary Table from BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d35750181befe4f5da4f650722948e9
https://doi.org/10.1158/2159-8290.22541856.v1
https://doi.org/10.1158/2159-8290.22541856.v1
Autor:
Mariella G. Filbin, Jun Qi, Todd R. Golub, Michelle Monje, Charles D. Stiles, Kimberly Stegmaier, Nathalie Y.R. Agar, Sameer Agnihotri, Yang Shi, Keith L. Ligon, Quang-De Nguyen, Jaume Mora, Cinzia Lavarino, Angel M. Carcaboso, Mario L. Suvà, Sirano Dhe-Paganon, Nathan D. Mathewson, William P. Jerome, Puspalata Bashyal, Kijun Song, Hyuk-Soo Seo, Yu Liang, Michael S. Regan, Sylwia Stopka, Amy Saur Conway, Kristen L. Jones, Jamie N. Anastas, David E. Root, John G. Doench, Federica Piccioni, Francisca Vazquez, Amy Goodale, Zohra Kalani, Meghan Wyatt, Ann-Catherine J. Stanton, Michael A. Quezada, Logan H. Sigua, Lingling Dai, Caleb Lareau, Joshua M. Dempster, Olivia A. Hack, Hafsa M. Mire, McKenzie L. Shaw, Guillaume Kugener, Samantha E. Hoffman, Deyao Li, Neekesh V. Dharia, Andrew Groves, Alexander Beck, Li Jiang, Ilon Liu, Maria C. Trissal, Tingjian Wang, Joana G. Marques, Eshini Panditharatna
Supplementary Figure from BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f64519af0b30cd43dfae7d183877165
https://doi.org/10.1158/2159-8290.22541865
https://doi.org/10.1158/2159-8290.22541865
Autor:
Mariella G. Filbin, Jun Qi, Todd R. Golub, Michelle Monje, Charles D. Stiles, Kimberly Stegmaier, Nathalie Y.R. Agar, Sameer Agnihotri, Yang Shi, Keith L. Ligon, Quang-De Nguyen, Jaume Mora, Cinzia Lavarino, Angel M. Carcaboso, Mario L. Suvà, Sirano Dhe-Paganon, Nathan D. Mathewson, William P. Jerome, Puspalata Bashyal, Kijun Song, Hyuk-Soo Seo, Yu Liang, Michael S. Regan, Sylwia Stopka, Amy Saur Conway, Kristen L. Jones, Jamie N. Anastas, David E. Root, John G. Doench, Federica Piccioni, Francisca Vazquez, Amy Goodale, Zohra Kalani, Meghan Wyatt, Ann-Catherine J. Stanton, Michael A. Quezada, Logan H. Sigua, Lingling Dai, Caleb Lareau, Joshua M. Dempster, Olivia A. Hack, Hafsa M. Mire, McKenzie L. Shaw, Guillaume Kugener, Samantha E. Hoffman, Deyao Li, Neekesh V. Dharia, Andrew Groves, Alexander Beck, Li Jiang, Ilon Liu, Maria C. Trissal, Tingjian Wang, Joana G. Marques, Eshini Panditharatna
Diffuse midline gliomas are uniformly fatal pediatric central nervous system cancers that are refractory to standard-of-care therapeutic modalities. The primary genetic drivers are a set of recurrent amino acid substitutions in genes encoding histone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57ee08482da42079229242adda130064
https://doi.org/10.1158/2159-8290.c.6549756
https://doi.org/10.1158/2159-8290.c.6549756
Autor:
Charles D. Stiles, Sérgio P.A. Toledo, Cheng Li, César Y. Hayashida, Alberto Cascon, Neil Aronin, Danielle Magoffin, Ken Ross, Miguel A.G. Pujana, Christian Colin, John Rogus, Ke Hao, Patricia L.M. Dahia
Pheochromocytomas are catecholamine-secreting tumors that result from mutations of at least six different genes as components of distinct autosomal dominant disorders. However, there remain familial occurrences of pheochromocytoma without a known gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a007f5a4a595daafed5db93b4095d3d1
https://doi.org/10.1158/0008-5472.c.6496007
https://doi.org/10.1158/0008-5472.c.6496007
Autor:
Charles D. Stiles, Sérgio P.A. Toledo, Cheng Li, César Y. Hayashida, Alberto Cascon, Neil Aronin, Danielle Magoffin, Ken Ross, Miguel A.G. Pujana, Christian Colin, John Rogus, Ke Hao, Patricia L.M. Dahia
Supplementary Data and Table 1 from Novel Pheochromocytoma Susceptibility Loci Identified by Integrative Genomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2009a0b27adbf51f882618e2d14c6fd5
https://doi.org/10.1158/0008-5472.22368569.v1
https://doi.org/10.1158/0008-5472.22368569.v1
Autor:
Kristine Pelton, Prasidda Khadka, Kenin Qian, Zachary T. Herbert, Guillaume Bergthold, Mariella G. Filbin, Liliana Goumnerova, Aviv Regev, Robert T. Jones, John F. Daley, Jessica Weatherbee, Yu Sun, Ying Huang, Keith L. Ligon, Orit Rozenblatt-Rosen, Pratiti Bandopadhayay, Rameen Beroukhim, Claire Sinai, John A. Alberta, Brenton R. Paolella, Alex K. Shalek, Zachary J. Reitman, Sarah Becker, Rosalind A. Segal, Mark W. Kieran, Alexandra L. Condurat, Daphne A. Haas-Kogan, Charles D. Stiles, Hayley Malkin, Leslie Grimmet, Mario L. Suvà
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma with a single driver BRAF rearrangement. Here, we perform scRNAseq in six PAs using methods that enabled detection of the rearrangement. When compared to higher-