Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Charles D Murin"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/3fc074a0f69b4999a86dde83eaf5c13d
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Monoclonal antibodies (mAbs) have proven effective for the treatment of ebolavirus infection in humans, with two mAb-based drugs Inmazeb™ and Ebanga™ receiving FDA approval in 2020. While these drugs represent a major advance in the field of filo
Externí odkaz:
https://doaj.org/article/3d8221729b754c6a80c2933ef7702fe8
Autor:
Charles D. Murin, Pavlo Gilchuk, Philipp A. Ilinykh, Kai Huang, Natalia Kuzmina, Xiaoli Shen, Jessica F. Bruhn, Aubrey L. Bryan, Edgar Davidson, Benjamin J. Doranz, Lauren E. Williamson, Jeffrey Copps, Tanwee Alkutkar, Andrew I. Flyak, Alexander Bukreyev, James E. Crowe, Jr., Andrew B. Ward
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108984- (2021)
Summary: Antibodies that target the glycan cap epitope on the ebolavirus glycoprotein (GP) are common in the adaptive response of survivors. A subset is known to be broadly neutralizing, but the details of their epitopes and basis for neutralization
Externí odkaz:
https://doaj.org/article/165fbb29f604470fb6b0a404b517d2da
Considerations of Antibody Geometric Constraints on NK Cell Antibody Dependent Cellular Cytotoxicity
Autor:
Charles D. Murin
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
It has been well-established that antibody isotype, glycosylation, and epitope all play roles in the process of antibody dependent cellular cytotoxicity (ADCC). For natural killer (NK) cells, these phenotypes are linked to cellular activation through
Externí odkaz:
https://doaj.org/article/2e666312bd8749689a697a9193e53361
Autor:
Katie A. Howell, Xiangguo Qiu, Jennifer M. Brannan, Christopher Bryan, Edgar Davidson, Frederick W. Holtsberg, Anna Z. Wec, Sergey Shulenin, Julia E. Biggins, Robin Douglas, Sven G. Enterlein, Hannah L. Turner, Jesper Pallesen, Charles D. Murin, Shihua He, Andrea Kroeker, Hong Vu, Andrew S. Herbert, Marnie L. Fusco, Elisabeth K. Nyakatura, Jonathan R. Lai, Zhen-Yong Keck, Steven K.H. Foung, Erica Ollmann Saphire, Larry Zeitlin, Andrew B. Ward, Kartik Chandran, Benjamin J. Doranz, Gary P. Kobinger, John M. Dye, M. Javad Aman
Publikováno v:
Cell Reports, Vol 15, Iss 7, Pp 1514-1526 (2016)
Summary: Previous efforts to identify cross-neutralizing antibodies to the receptor-binding site (RBS) of ebolavirus glycoproteins have been unsuccessful, largely because the RBS is occluded on the viral surface. We report a monoclonal antibody (FVM0
Externí odkaz:
https://doaj.org/article/8cb2b4542b0546a695db88b408e10d26
Autor:
Charles D. Murin, Jessica F. Bruhn, Zachary A. Bornholdt, Jeffrey Copps, Robyn Stanfield, Andrew B. Ward
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2723-2732.e4 (2018)
Summary: Monoclonal antibodies (mAbs) with pan-ebolavirus cross-reactivity are highly desirable, but development of such mAbs is limited by a lack of a molecular understanding of cross-reactive epitopes. The antibody ADI-15878 was previously identifi
Externí odkaz:
https://doaj.org/article/a325cbc4aed54ac3ac92a8e7ae166d30
Autor:
Marnie L Fusco, Takao Hashiguchi, Robyn Cassan, Julia E Biggins, Charles D Murin, Kelly L Warfield, Sheng Li, Frederick W Holtsberg, Sergey Shulenin, Hong Vu, Gene G Olinger, Do H Kim, Kevin J Whaley, Larry Zeitlin, Andrew B Ward, Cory Nykiforuk, M Javad Aman, Jody D Berry, Erica Ollmann Saphire
Publikováno v:
PLoS Pathogens, Vol 11, Iss 10, p e1005212 (2015)
Externí odkaz:
https://doaj.org/article/2f7b06399f1047a9997e8c106e3d84e0
Autor:
Marnie L Fusco, Takao Hashiguchi, Robyn Cassan, Julia E Biggins, Charles D Murin, Kelly L Warfield, Sheng Li, Frederick W Holtsberg, Sergey Shulenin, Hong Vu, Gene G Olinger, Do H Kim, Kevin J Whaley, Larry Zeitlin, Andrew B Ward, Cory Nykiforuk, M Javad Aman, Jody D Berry, Erica Ollmann Saphire
Publikováno v:
PLoS Pathogens, Vol 11, Iss 6, p e1005016 (2015)
The filoviruses, which include the marburg- and ebolaviruses, have caused multiple outbreaks among humans this decade. Antibodies against the filovirus surface glycoprotein (GP) have been shown to provide life-saving therapy in nonhuman primates, but
Externí odkaz:
https://doaj.org/article/0eef54b956b34015946458e1d84e03e4
Publikováno v:
Nature microbiology
Antibodies serve as critical barriers to viral infection. Humoral immunity to a virus is achieved through the dual role of antibodies in communicating the presence of invading pathogens in infected cells to effector cells, and in interfering with pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2564760d1da5f51324dfea37d30b0613
https://doi.org/10.1038/s41564-019-0392-y
https://doi.org/10.1038/s41564-019-0392-y
Autor:
Robert H. Carnahan, Seth J. Zost, Charles D. Murin, Alexander Bukreyev, Viktoriya Borisevich, Philipp A. Ilinykh, Naveenchandra Suryadevara, Robert W. Cross, James E. Crowe, Thomas W. Geisbert, Rachel S. Nargi, Andrew B. Ward, Robin G. Bombardi, Joan B. Geisbert, Pavlo Gilchuk, Krystle N. Agans, Kai Huang, Natalia Kuzmina, Rachel E. Sutton
Ebolaviruses cause a severe and often fatal illness with the potential for global spread. Monoclonal antibody-based treatments that have become available recently have a narrow therapeutic spectrum and are ineffective against ebolaviruses other than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0047e118fd5b651dfed3ff6266a8f4c7
https://doi.org/10.1101/2021.05.02.442324
https://doi.org/10.1101/2021.05.02.442324
